TAOK2
Summary: This gene encodes a serine/threonine protein kinase that is involved in many different processes, including, cell signaling, microtubule organization and stability, and apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TAO kinase 2 | MIM:613199 | Ensembl:ENSG00000149930 | HGNC:HGNC:16835 | PA134907964 | 16p11.2 |
GO terms in TAOK2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | NAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | NAS | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0031434 | mitogen-activated protein kinase kinase binding |
| MF | IPI | GO:0038191 | neuropilin binding |
| BP | IBA | GO:0000186 | activation of MAPKK activity |
| BP | IDA | GO:0000186 | activation of MAPKK activity |
| BP | TAS | GO:0000187 | activation of MAPK activity |
| BP | NAS | GO:0001558 | regulation of cell growth |
| BP | NAS | GO:0006612 | protein targeting to membrane |
| BP | NAS | GO:0006915 | apoptotic process |
| BP | IDA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IMP | GO:0007095 | mitotic G2 DNA damage checkpoint |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IGI | GO:0007409 | axonogenesis |
| BP | ISS | GO:0007409 | axonogenesis |
| BP | IDA | GO:0008360 | regulation of cell shape |
| BP | NAS | GO:0016477 | cell migration |
| BP | IBA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IDA | GO:0030036 | actin cytoskeleton organization |
| BP | TAS | GO:0031954 | positive regulation of protein autophosphorylation |
| BP | IBA | GO:0032147 | activation of protein kinase activity |
| BP | TAS | GO:0032147 | activation of protein kinase activity |
| BP | IMP | GO:0032874 | positive regulation of stress-activated MAPK cascade |
| BP | ISS | GO:0032956 | regulation of actin cytoskeleton organization |
| BP | IDA | GO:0046330 | positive regulation of JNK cascade |
| BP | ISS | GO:0046330 | positive regulation of JNK cascade |
| BP | TAS | GO:0046777 | protein autophosphorylation |
| BP | IDA | GO:0048041 | focal adhesion assembly |
| BP | IDA | GO:0051403 | stress-activated MAPK cascade |
| BP | ISS | GO:0150019 | basal dendrite morphogenesis |
| BP | ISS | GO:0150020 | basal dendrite arborization |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | ISS | GO:0015629 | actin cytoskeleton |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | ISS | GO:0030424 | axon |
| CC | IEA | GO:0030659 | cytoplasmic vesicle membrane |
| CC | IDA | GO:0031410 | cytoplasmic vesicle |
| CC | ISS | GO:0043005 | neuron projection |
| CC | IDA | GO:0043235 | receptor complex |
| CC | ISS | GO:0044294 | dendritic growth cone |
| CC | ISS | GO:0044295 | axonal growth cone |
Gene expression in normal tissue: TAOK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TAOK2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | p38_mkk3_6pathway | p38 MAPK signaling pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| wikipathways | WP382 | MAPK Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD782 | DC-45-A2 | 5 |
| iGMDRD294 | Batimastat | 1 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD577 | BIX01294 | 4 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD483 | SCH-529074 | 1 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD634 | SCHEMBL2608041 | 5 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD61 | Kinetin riboside | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TAOK2
CLASSFICATION
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