UBR5

Summary: This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameubiquitin protein ligase E3 component n-recognin 5
OMIM IDMIM:608413
Ensembl IDEnsembl:ENSG00000104517
HGNC IDHGNC:HGNC:16806
PHARMGKB IDPA162408175
Map Location8q22.3

GO terms in UBR5


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IBA GO:0005634 nucleus
CC IDA GO:0005634 nucleus
CC IDA GO:0005654 nucleoplasm
CC IDA GO:0005829 cytosol
CC HDA GO:0016020 membrane
CC IDA GO:0032991 protein-containing complex
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Gene expression in normal tissue: UBR5

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 9OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 42undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 52undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 3BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 45UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 8

Gene-drug pathway distribution

Pathways in UBR5


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Database
Pathway ID
Pathway Des.
wikipathways WP2857 Mesodermal Commitment Pathway
wikipathways WP465 Tryptophan metabolism
kegg hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD451 Serdemetan 1
iGMDRD23 Gossypol 3
iGMDRD64 Parbendazole 1
iGMDRD398 Sepantronium 6
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in UBR5

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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