UBR5
Summary: This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ubiquitin protein ligase E3 component n-recognin 5 | MIM:608413 | Ensembl:ENSG00000104517 | HGNC:HGNC:16806 | PA162408175 | 8q22.3 |
GO terms in UBR5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| BP | IBA | GO:0000209 | protein polyubiquitination |
| BP | IDA | GO:0000209 | protein polyubiquitination |
| BP | IEA | GO:0006281 | DNA repair |
| BP | TAS | GO:0006511 | ubiquitin-dependent protein catabolic process |
| BP | IBA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IDA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IMP | GO:0006974 | cellular response to DNA damage stimulus |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | IDA | GO:0010628 | positive regulation of gene expression |
| BP | IMP | GO:0033160 | positive regulation of protein import into nucleus, translocation |
| BP | IDA | GO:0050847 | progesterone receptor signaling pathway |
| BP | IDA | GO:0070936 | protein K48-linked ubiquitination |
| BP | IMP | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| BP | IBA | GO:1901315 | negative regulation of histone H2A K63-linked ubiquitination |
| BP | IMP | GO:1901315 | negative regulation of histone H2A K63-linked ubiquitination |
| BP | IBA | GO:2000779 | regulation of double-strand break repair |
| BP | IMP | GO:2000780 | negative regulation of double-strand break repair |
| MF | IEA | GO:0003723 | RNA binding |
| MF | TAS | GO:0004842 | ubiquitin-protein transferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IDA | GO:0034450 | ubiquitin-ubiquitin ligase activity |
| MF | IEA | GO:0043130 | ubiquitin binding |
| MF | IDA | GO:0061630 | ubiquitin protein ligase activity |
Gene expression in normal tissue: UBR5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in UBR5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP465 | Tryptophan metabolism |
| kegg | hsa04120 | Ubiquitin mediated proteolysis - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD451 | Serdemetan | 1 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD398 | Sepantronium | 6 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD74 | Idarubicin | 9 |
| iGMDRD100 | Zebularine | 6 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD613 | CHEMBL258148 | 1 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD260 | FQI-2 | 3 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD513 | BML-259 | 3 |
| iGMDRD466 | Chaetocin | 1 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD71 | Sparfosic acid | 3 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD151 | CHM-1 | 6 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD366 | PI-103 | 6 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD289 | Parthenolide | 6 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD158 | NSC141540 | 6 |
| iGMDRD121 | GMX1778 | 4 |
| iGMDRD945 | ML214 | 1 |
| iGMDRD123 | Isoevodiamine | 6 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD351 | GW843682X | 6 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD79 | Gemcitabine | 4 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 1 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD84 | Lovastatin acid | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in UBR5
CLASSFICATION
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