ADAM28
Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. This gene is present in a gene cluster with other members of the ADAM family on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ADAM metallopeptidase domain 28 | MIM:606188 | Ensembl:ENSG00000042980 | HGNC:HGNC:206 | PA24523 | 8p21.2 |
GO terms in ADAM28
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005576 | extracellular region |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| BP | IEA | GO:0006508 | proteolysis |
| BP | TAS | GO:0007283 | spermatogenesis |
| MF | IEA | GO:0004222 | metalloendopeptidase activity |
| MF | IDA | GO:0008237 | metallopeptidase activity |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: ADAM28
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ADAM28
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | integrin_a4b1_pathway | Alpha4 beta1 integrin signaling events |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD294 | Batimastat | 3 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD270 | Ciclosporin | 2 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD64 | Parbendazole | 4 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD268 | Cerulenin | 3 |
| iGMDRD23 | Gossypol | 6 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD483 | SCH-529074 | 4 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD433 | Lexibulin | 2 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD425 | ERASTIN | 3 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD297 | Austocystin D | 6 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD434 | BMS-536924 | 5 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD415 | LE-135 | 3 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD269 | Purmorphamine | 2 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD150 | RITA | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 2 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ADAM28
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.