ADAM28


Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. This gene is present in a gene cluster with other members of the ADAM family on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ADAM metallopeptidase domain 28MIM:606188Ensembl:ENSG00000042980HGNC:HGNC:206PA245238p21.2

GO terms in ADAM28


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0005576extracellular region
CCIDAGO:0005739mitochondrion
CCIDAGO:0005886plasma membrane
CCIEAGO:0016021integral component of membrane
BPIEAGO:0006508proteolysis
BPTASGO:0007283spermatogenesis
MFIEAGO:0004222metalloendopeptidase activity
MFIDAGO:0008237metallopeptidase activity
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: ADAM28

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ADAM28


DatabasePathway IDPathway Des.
pidintegrin_a4b1_pathwayAlpha4 beta1 integrin signaling events

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD171Pemetrexed3
iGMDRD870BRD636102
iGMDRD294Batimastat3
iGMDRD187BRD98763
iGMDRD138PX 122
iGMDRD270Ciclosporin2
iGMDRD513BML-2591
iGMDRD64Parbendazole4
iGMDRD524ISX-92
iGMDRD268Cerulenin3
iGMDRD23Gossypol6
iGMDRD356PNU-746543
iGMDRD74Idarubicin3
iGMDRD188Piperlongumine3
iGMDRD100Zebularine3
iGMDRD398Sepantronium2
iGMDRD506Fedratinib2
iGMDRD781Sirolimus3
iGMDRD483SCH-5290744
iGMDRD494Neopeltolide2
iGMDRD433Lexibulin2
iGMDRD126Tipifarnib3
iGMDRD425ERASTIN3
iGMDRD387CHIR-990211
iGMDRD466Chaetocin2
iGMDRD297Austocystin D6
iGMDRD446LY 21832403
iGMDRD193Fqi13
iGMDRD434BMS-5369245
iGMDRD6AM-5803
iGMDRD415LE-1353
iGMDRD137Indisulam1
iGMDRD5Tyrphostin AG 14783
iGMDRD872BRD71373
iGMDRD414MST-3122
iGMDRD286Nsc 6328392
iGMDRD871BRD63683
iGMDRD269Purmorphamine2
iGMDRD329Merck603
iGMDRD345Compound 10b [PMID: 11504634]2
iGMDRD150RITA3
iGMDRD523Cyanoquinoline, 112
iGMDRD512nutlin 32
iGMDRD123Isoevodiamine2
iGMDRD901ELCPK3
iGMDRD132(-)-gallocatechin-3-O-gallate1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ADAM28

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