ATP10A
Summary: The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. This gene is maternally expressed. It maps within the most common interval of deletion responsible for Angelman syndrome, also known as 'happy puppet syndrome'. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ATPase phospholipid transporting 10A (putative) | MIM:605855 | Ensembl:ENSG00000206190 | HGNC:HGNC:13542 | PA25097 | 15q12 |
GO terms in ATP10A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0000287 | magnesium ion binding |
| MF | IBA | GO:0004012 | phospholipid-translocating ATPase activity |
| MF | NAS | GO:0004012 | phospholipid-translocating ATPase activity |
| MF | TAS | GO:0004012 | phospholipid-translocating ATPase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| BP | NAS | GO:0008360 | regulation of cell shape |
| BP | TAS | GO:0034220 | ion transmembrane transport |
| BP | IBA | GO:0045332 | phospholipid translocation |
| BP | NAS | GO:0045332 | phospholipid translocation |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | IEA | GO:0005789 | endoplasmic reticulum membrane |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | NAS | GO:0016021 | integral component of membrane |
Gene expression in normal tissue: ATP10A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ATP10A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3998 | Prader-Willi and Angelman Syndrome |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-936837 | Ion transport by P-type ATPases |
| reactome | R-HSA-983712 | Ion channel transport |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD444 | Tivantinib | 3 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD730 | Kahalalide F | 3 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD188 | Piperlongumine | 6 |
| iGMDRD138 | PX 12 | 1 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD446 | LY 2183240 | 5 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD144 | NSC95397 | 7 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD263 | AACOCF3 | 2 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD414 | MST-312 | 4 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD137 | Indisulam | 6 |
| iGMDRD103 | SN-38 | 4 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD532 | Olaparib | 2 |
| iGMDRD116 | CD437 | 1 |
| iGMDRD150 | RITA | 10 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD405 | PIK-75 | 1 |
| iGMDRD512 | nutlin 3 | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ATP10A
CLASSFICATION
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