ATP10A

Summary: The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. This gene is maternally expressed. It maps within the most common interval of deletion responsible for Angelman syndrome, also known as 'happy puppet syndrome'. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameATPase phospholipid transporting 10A (putative)
OMIM IDMIM:605855
Ensembl IDEnsembl:ENSG00000206190
HGNC IDHGNC:HGNC:13542
PHARMGKB IDPA25097
Map Location15q12

GO terms in ATP10A


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0000287 magnesium ion binding
MF IBA GO:0004012 phospholipid-translocating ATPase activity
MF NAS GO:0004012 phospholipid-translocating ATPase activity
MF TAS GO:0004012 phospholipid-translocating ATPase activity
MF IPI GO:0005515 protein binding
MF IEA GO:0005524 ATP binding
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Gene expression in normal tissue: ATP10A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined30Cell cycle1Genome integrity1DNA replication1Protein stability and degradation1Longevity regulating pathway1Biosynthesis of secondary metabolites1Proteasome1RTK signaling1

Pathways in ATP10A


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Database
Pathway ID
Pathway Des.
wikipathways WP3998 Prader-Willi and Angelman Syndrome
reactome R-HSA-382551 Transport of small molecules
reactome R-HSA-936837 Ion transport by P-type ATPases
reactome R-HSA-983712 Ion channel transport
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD444 Tivantinib 3
iGMDRD23 Gossypol 2
iGMDRD887 Compound 23 citrate 2
iGMDRD730 Kahalalide F 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ATP10A

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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