CSNK2A2


Summary: This gene encodes the alpha', or alpha 2, catalytic subunit of the protein kinase enzyme, casein kinase 2 (CK2). Casein kinase 2 is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. This heterotetrameric kinase includes two catalytic subunits, either alpha or alpha', and two regulatory beta subunits. The closely related gene paralog encoding the alpha, or alpha 1 subunit (CSNK2A1, Gene ID: 1457) is found on chromosome 20. An intronic variant in this gene (alpha 2) may be associated with leukocyte telomere length in a South Asian population. A related transcribed pseudogene is found on chromosome 11. [provided by RefSeq, Aug 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
casein kinase 2 alpha 2MIM:115442Ensembl:ENSG00000070770HGNC:HGNC:2459PA2695916q21

GO terms in CSNK2A2


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006355regulation of transcription, DNA-templated
BPIEAGO:0006915apoptotic process
BPIEAGO:0007049cell cycle
BPIEAGO:0007283spermatogenesis
BPIEAGO:0016055Wnt signaling pathway
BPIDAGO:0018105peptidyl-serine phosphorylation
BPIEAGO:0021987cerebral cortex development
BPIEAGO:0097421liver regeneration
BPTASGO:1901796regulation of signal transduction by p53 class mediator
BPHMPGO:1903146regulation of autophagy of mitochondrion
BPHMPGO:1903955positive regulation of protein targeting to mitochondrion
BPIMPGO:1905818regulation of chromosome separation
BPIGIGO:2000059negative regulation of ubiquitin-dependent protein catabolic process
BPTASGO:2001234negative regulation of apoptotic signaling pathway
CCIEAGO:0000785chromatin
CCIEAGO:0001669acrosomal vesicle
CCHDAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCTASGO:0005829cytosol
CCIEAGO:0005886plasma membrane
CCIDAGO:0031519PcG protein complex
MFIGIGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIPIGO:0047485protein N-terminus binding

Gene expression in normal tissue: CSNK2A2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CSNK2A2


DatabasePathway IDPathway Des.
wikipathwaysWP2328Allograft Rejection
wikipathwaysWP428Wnt Signaling Pathway
kegghsa03008Ribosome biogenesis in eukaryotes - Homo sapiens (human)
kegghsa04064NF-kappa B signaling pathway - Homo sapiens (human)
kegghsa04137Mitophagy - animal - Homo sapiens (human)
kegghsa04310Wnt signaling pathway - Homo sapiens (human)
kegghsa04520Adherens junction - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1483191Synthesis of PC
reactomeR-HSA-1483206Glycerophospholipid biosynthesis
reactomeR-HSA-1483257Phospholipid metabolism
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-201688WNT mediated activation of DVL
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2514853Condensation of Prometaphase Chromosomes
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-373760L1CAM interactions
reactomeR-HSA-390466Chaperonin-mediated protein folding
reactomeR-HSA-391251Protein folding
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-445144Signal transduction by L1
reactomeR-HSA-5205647Mitophagy
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-6804756Regulation of TP53 Activity through Phosphorylation
reactomeR-HSA-6807070PTEN Regulation
reactomeR-HSA-6814122Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
reactomeR-HSA-68877Mitotic Prometaphase
reactomeR-HSA-68886M Phase
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8934903Receptor Mediated Mitophagy
reactomeR-HSA-8939243RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
reactomeR-HSA-8948751Regulation of PTEN stability and activity
reactomeR-HSA-9006925Intracellular signaling by second messengers

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD560MK-22062
iGMDRD345Compound 10b [PMID: 11504634]4
iGMDRD84Lovastatin acid1
iGMDRD330BRD41322
iGMDRD486Tosedostat5
iGMDRD512nutlin 32
iGMDRD132(-)-gallocatechin-3-O-gallate2
iGMDRD154NSC237661
iGMDRD945ML2142
iGMDRD698Neratinib6
iGMDRD289Parthenolide6
iGMDRD434BMS-5369242
iGMDRD251ML1623
iGMDRD202Curcumin6
iGMDRD5Tyrphostin AG 14786
iGMDRD552AZD-17754
iGMDRD263AACOCF36
iGMDRD871BRD63686
iGMDRD329Merck602
iGMDRD144NSC953974
iGMDRD483SCH-5290742
iGMDRD494Neopeltolide2
iGMDRD781Sirolimus4
iGMDRD387CHIR-990213
iGMDRD280CYTOCHALASIN B1
iGMDRD679Bistramide A1
iGMDRD634SCHEMBL26080414
iGMDRD446LY 21832403
iGMDRD193Fqi12
iGMDRD152179324-69-72
iGMDRD61Kinetin riboside2
iGMDRD885Compound 1102
iGMDRD138PX 123
iGMDRD60Quinoclamine2
iGMDRD268Cerulenin2
iGMDRD188Piperlongumine4
iGMDRD399Selumetinib2
iGMDRD506Fedratinib4
iGMDRD780PP-303
iGMDRD562Navitoclax2
iGMDRD398Sepantronium2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CSNK2A2

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