CSNK2A2
Summary: This gene encodes the alpha', or alpha 2, catalytic subunit of the protein kinase enzyme, casein kinase 2 (CK2). Casein kinase 2 is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. This heterotetrameric kinase includes two catalytic subunits, either alpha or alpha', and two regulatory beta subunits. The closely related gene paralog encoding the alpha, or alpha 1 subunit (CSNK2A1, Gene ID: 1457) is found on chromosome 20. An intronic variant in this gene (alpha 2) may be associated with leukocyte telomere length in a South Asian population. A related transcribed pseudogene is found on chromosome 11. [provided by RefSeq, Aug 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| casein kinase 2 alpha 2 | MIM:115442 | Ensembl:ENSG00000070770 | HGNC:HGNC:2459 | PA26959 | 16q21 |
GO terms in CSNK2A2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | IEA | GO:0016055 | Wnt signaling pathway |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IEA | GO:0021987 | cerebral cortex development |
| BP | IEA | GO:0097421 | liver regeneration |
| BP | TAS | GO:1901796 | regulation of signal transduction by p53 class mediator |
| BP | HMP | GO:1903146 | regulation of autophagy of mitochondrion |
| BP | HMP | GO:1903955 | positive regulation of protein targeting to mitochondrion |
| BP | IMP | GO:1905818 | regulation of chromosome separation |
| BP | IGI | GO:2000059 | negative regulation of ubiquitin-dependent protein catabolic process |
| BP | TAS | GO:2001234 | negative regulation of apoptotic signaling pathway |
| CC | IEA | GO:0000785 | chromatin |
| CC | IEA | GO:0001669 | acrosomal vesicle |
| CC | HDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0031519 | PcG protein complex |
| MF | IGI | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0047485 | protein N-terminus binding |
Gene expression in normal tissue: CSNK2A2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CSNK2A2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2328 | Allograft Rejection |
| wikipathways | WP428 | Wnt Signaling Pathway |
| kegg | hsa03008 | Ribosome biogenesis in eukaryotes - Homo sapiens (human) |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04137 | Mitophagy - animal - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04520 | Adherens junction - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1483191 | Synthesis of PC |
| reactome | R-HSA-1483206 | Glycerophospholipid biosynthesis |
| reactome | R-HSA-1483257 | Phospholipid metabolism |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-201688 | WNT mediated activation of DVL |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2514853 | Condensation of Prometaphase Chromosomes |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-390466 | Chaperonin-mediated protein folding |
| reactome | R-HSA-391251 | Protein folding |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-445144 | Signal transduction by L1 |
| reactome | R-HSA-5205647 | Mitophagy |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation |
| reactome | R-HSA-6807070 | PTEN Regulation |
| reactome | R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8934903 | Receptor Mediated Mitophagy |
| reactome | R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
| reactome | R-HSA-8948751 | Regulation of PTEN stability and activity |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 4 |
| iGMDRD84 | Lovastatin acid | 1 |
| iGMDRD330 | BRD4132 | 2 |
| iGMDRD486 | Tosedostat | 5 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD698 | Neratinib | 6 |
| iGMDRD289 | Parthenolide | 6 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD202 | Curcumin | 6 |
| iGMDRD5 | Tyrphostin AG 1478 | 6 |
| iGMDRD552 | AZD-1775 | 4 |
| iGMDRD263 | AACOCF3 | 6 |
| iGMDRD871 | BRD6368 | 6 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD144 | NSC95397 | 4 |
| iGMDRD483 | SCH-529074 | 2 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD781 | Sirolimus | 4 |
| iGMDRD387 | CHIR-99021 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD634 | SCHEMBL2608041 | 4 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD885 | Compound 110 | 2 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD506 | Fedratinib | 4 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD398 | Sepantronium | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CSNK2A2
CLASSFICATION
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