RNASEH2A
Summary: The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.[provided by RefSeq, Aug 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ribonuclease H2 subunit A | MIM:606034 | Ensembl:ENSG00000104889 | HGNC:HGNC:18518 | PA38565 | 19p13.13 |
Gene Categories:
DNA REPAIRGO terms in RNASEH2A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003723 | RNA binding |
| MF | IBA | GO:0004523 | RNA-DNA hybrid ribonuclease activity |
| MF | IDA | GO:0004523 | RNA-DNA hybrid ribonuclease activity |
| MF | TAS | GO:0004540 | ribonuclease activity |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IBA | GO:0032299 | ribonuclease H2 complex |
| CC | IDA | GO:0032299 | ribonuclease H2 complex |
| BP | TAS | GO:0006260 | DNA replication |
| BP | IBA | GO:0006298 | mismatch repair |
| BP | IDA | GO:0006298 | mismatch repair |
| BP | IDA | GO:0006401 | RNA catabolic process |
| BP | IBA | GO:0043137 | DNA replication, removal of RNA primer |
| BP | IEA | GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic |
Gene expression in normal tissue: RNASEH2A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RNASEH2A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa03030 | DNA replication - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD213 | SMR000068650 | 3 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
| iGMDRD201 | SKI II | 1 |
| iGMDRD341 | Triacsin c | 6 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 2 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RNASEH2A
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