PRRX1


Summary: The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription co-activator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. The protein regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
paired related homeobox 1MIM:167420Ensembl:ENSG00000116132HGNC:HGNC:9142PA334661q24.2

GO terms in PRRX1


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFTASGO:0003713transcription coactivator activity
MFIEAGO:0071837HMG box domain binding
CCIDAGO:0005654nucleoplasm
CCIDAGO:0005829cytosol
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0002053positive regulation of mesenchymal cell proliferation
BPIEAGO:0030326embryonic limb morphogenesis
BPIEAGO:0042472inner ear morphogenesis
BPIEAGO:0042474middle ear morphogenesis
BPIEAGO:0045880positive regulation of smoothened signaling pathway
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0048664neuron fate determination
BPIEAGO:0048701embryonic cranial skeleton morphogenesis
BPIEAGO:0048844artery morphogenesis
BPIEAGO:0051216cartilage development
BPIEAGO:0060021roof of mouth development
BPIEAGO:0070570regulation of neuron projection regeneration
BPIEAGO:0097150neuronal stem cell population maintenance

Gene expression in normal tissue: PRRX1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRRX1


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD446LY 21832403
iGMDRD351GW843682X2
iGMDRD57Chloropentafluorobenzene3
iGMDRD280CYTOCHALASIN B2
iGMDRD150RITA2
iGMDRD345Compound 10b [PMID: 11504634]6
iGMDRD188Piperlongumine3
iGMDRD286Nsc 6328395
iGMDRD74Idarubicin6
iGMDRD577BIX012943
iGMDRD398Sepantronium3
iGMDRD886Compound 1541A3
iGMDRD271Brefeldin A3
iGMDRD705Nakiterpiosin3
iGMDRD434BMS-5369244
iGMDRD318PAC-11

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRRX1

​​​​