PRRX1
Summary: The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription co-activator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. The protein regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| paired related homeobox 1 | MIM:167420 | Ensembl:ENSG00000116132 | HGNC:HGNC:9142 | PA33466 | 1q24.2 |
GO terms in PRRX1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0001078 | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | TAS | GO:0003713 | transcription coactivator activity |
| MF | IEA | GO:0071837 | HMG box domain binding |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0002053 | positive regulation of mesenchymal cell proliferation |
| BP | IEA | GO:0030326 | embryonic limb morphogenesis |
| BP | IEA | GO:0042472 | inner ear morphogenesis |
| BP | IEA | GO:0042474 | middle ear morphogenesis |
| BP | IEA | GO:0045880 | positive regulation of smoothened signaling pathway |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0048664 | neuron fate determination |
| BP | IEA | GO:0048701 | embryonic cranial skeleton morphogenesis |
| BP | IEA | GO:0048844 | artery morphogenesis |
| BP | IEA | GO:0051216 | cartilage development |
| BP | IEA | GO:0060021 | roof of mouth development |
| BP | IEA | GO:0070570 | regulation of neuron projection regeneration |
| BP | IEA | GO:0097150 | neuronal stem cell population maintenance |
Gene expression in normal tissue: PRRX1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRRX1
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD150 | RITA | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 6 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD286 | Nsc 632839 | 5 |
| iGMDRD74 | Idarubicin | 6 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD434 | BMS-536924 | 4 |
| iGMDRD318 | PAC-1 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRRX1
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