ADHFE1
Summary: The ADHFE1 gene encodes hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24), which is responsible for the oxidation of 4-hydroxybutyrate in mammalian tissues (Kardon et al., 2006 [PubMed 16616524]).[supplied by OMIM, Mar 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:611083 Ensembl IDEnsembl:ENSG00000147576 HGNC IDHGNC:HGNC:16354 PHARMGKB IDPA134871493 Map Location8q13.1 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in ADHFE1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0046872 | metal ion binding |
| MF | EXP | GO:0047988 | hydroxyacid-oxoacid transhydrogenase activity |
| MF | IDA | GO:0047988 | hydroxyacid-oxoacid transhydrogenase activity |
| CC | ISS | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005759 | mitochondrial matrix |
| BP | TAS | GO:0006103 | 2-oxoglutarate metabolic process |
Gene expression in normal tissue: ADHFE1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ADHFE1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1428517 | The citric acid (TCA) cycle and respiratory electron transport |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-71406 | Pyruvate metabolism and Citric Acid (TCA) cycle |
| reactome | R-HSA-880009 | Interconversion of 2-oxoglutarate and 2-hydroxyglutarate |
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Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ADHFE1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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