ADHFE1
Summary: The ADHFE1 gene encodes hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24), which is responsible for the oxidation of 4-hydroxybutyrate in mammalian tissues (Kardon et al., 2006 [PubMed 16616524]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| alcohol dehydrogenase, iron containing 1 | MIM:611083 | Ensembl:ENSG00000147576 | HGNC:HGNC:16354 | PA134871493 | 8q13.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in ADHFE1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0046872 | metal ion binding |
| MF | EXP | GO:0047988 | hydroxyacid-oxoacid transhydrogenase activity |
| MF | IDA | GO:0047988 | hydroxyacid-oxoacid transhydrogenase activity |
| CC | ISS | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005759 | mitochondrial matrix |
| BP | TAS | GO:0006103 | 2-oxoglutarate metabolic process |
| BP | IDA | GO:0006539 | glutamate catabolic process via 2-oxoglutarate |
| BP | IEA | GO:0055114 | oxidation-reduction process |
Gene expression in normal tissue: ADHFE1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ADHFE1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1428517 | The citric acid (TCA) cycle and respiratory electron transport |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-71406 | Pyruvate metabolism and Citric Acid (TCA) cycle |
| reactome | R-HSA-880009 | Interconversion of 2-oxoglutarate and 2-hydroxyglutarate |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD150 | RITA | 2 |
| iGMDRD79 | Gemcitabine | 6 |
| iGMDRD484 | Pluripotin | 4 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD237 | ABT-751 | 4 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD718 | Pyrvinium pamoate | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD705 | Nakiterpiosin | 9 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD415 | LE-135 | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD414 | MST-312 | 7 |
| iGMDRD286 | Nsc 632839 | 10 |
| iGMDRD577 | BIX01294 | 4 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD60 | Quinoclamine | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ADHFE1
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.