PAXIP1


Summary: This gene is a member of the paired box (PAX) gene family and encodes a nuclear protein with six BRCT (breast cancer carboxy-terminal) domains. This protein plays a critical role in maintaining genome stability, condensation of chromatin and progression through mitosis. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
PAX interacting protein 1MIM:608254Ensembl:ENSG00000157212HGNC:HGNC:8624PA329647q36.2

GO terms in PAXIP1


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIEAGO:0005694chromosome
CCIEAGO:0016363nuclear matrix
CCIDAGO:0035097histone methyltransferase complex
CCIDAGO:0044666MLL3/4 complex
BPISSGO:0000416positive regulation of histone H3-K36 methylation
BPIEAGO:0001570vasculogenesis
BPTASGO:0006303double-strand break repair via nonhomologous end joining
BPIEAGO:0006310DNA recombination
BPIEAGO:0006351transcription, DNA-templated
BPIDAGO:0010212response to ionizing radiation
BPIMPGO:0030330DNA damage response, signal transduction by p53 class mediator
BPISSGO:0031398positive regulation of protein ubiquitination
BPISSGO:0035066positive regulation of histone acetylation
BPIEAGO:0043542endothelial cell migration
BPISSGO:0045830positive regulation of isotype switching
BPIEAGO:0048304positive regulation of isotype switching to IgG isotypes
BPIDAGO:0051568histone H3-K4 methylation
BPISSGO:0051571positive regulation of histone H3-K4 methylation
BPIMPGO:0060261positive regulation of transcription initiation from RNA polymerase II promoter
BPISSGO:0060261positive regulation of transcription initiation from RNA polymerase II promoter
BPIEAGO:0060612adipose tissue development
BPIEAGO:0060717chorion development
BPIEAGO:1902749regulation of cell cycle G2/M phase transition
BPIEAGO:2001022positive regulation of response to DNA damage stimulus
MFIPIGO:0005515protein binding

Gene expression in normal tissue: PAXIP1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PAXIP1


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-5617472Activation of anterior HOX genes in hindbrain development during early embryogenesis
reactomeR-HSA-5619507Activation of HOX genes during differentiation
reactomeR-HSA-5693532DNA Double-Strand Break Repair
reactomeR-HSA-5693571Nonhomologous End-Joining (NHEJ)
reactomeR-HSA-73894DNA Repair

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD297Austocystin D1
iGMDRD466Chaetocin4
iGMDRD639YK 4-2793
iGMDRD152179324-69-76
iGMDRD61Kinetin riboside3
iGMDRD446LY 21832403
iGMDRD494Neopeltolide4
iGMDRD599Salermide2
iGMDRD420Leucascandrolide A3
iGMDRD772BRD47702
iGMDRD126Tipifarnib2
iGMDRD151CHM-12
iGMDRD23Gossypol3
iGMDRD268Cerulenin2
iGMDRD451Serdemetan2
iGMDRD64Parbendazole2
iGMDRD506Fedratinib1
iGMDRD188Piperlongumine4
iGMDRD74Idarubicin2
iGMDRD887Compound 23 citrate2
iGMDRD441TW 373
iGMDRD187BRD98762
iGMDRD52Rotenone3
iGMDRD782DC-45-A22
iGMDRD260FQI-23
iGMDRD8024-methylfasudil3
iGMDRD255SB2250022
iGMDRD138PX 122
iGMDRD945ML2142
iGMDRD132(-)-gallocatechin-3-O-gallate2
iGMDRD901ELCPK2
iGMDRD123Isoevodiamine2
iGMDRD351GW843682X3
iGMDRD237ABT-7512
iGMDRD85Ursolic acid4
iGMDRD345Compound 10b [PMID: 11504634]2
iGMDRD512nutlin 33
iGMDRD584VER 1550081
iGMDRD330BRD41322
iGMDRD42Vorinostat3
iGMDRD322FK 8662
iGMDRD246NPC264
iGMDRD263AACOCF32
iGMDRD414MST-3122
iGMDRD286Nsc 6328394
iGMDRD213SMR0000686502
iGMDRD289Parthenolide4
iGMDRD434BMS-5369241
iGMDRD103SN-382
iGMDRD121GMX17782

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PAXIP1

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