PAXIP1
Summary: This gene is a member of the paired box (PAX) gene family and encodes a nuclear protein with six BRCT (breast cancer carboxy-terminal) domains. This protein plays a critical role in maintaining genome stability, condensation of chromatin and progression through mitosis. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| PAX interacting protein 1 | MIM:608254 | Ensembl:ENSG00000157212 | HGNC:HGNC:8624 | PA32964 | 7q36.2 |
GO terms in PAXIP1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005694 | chromosome |
| CC | IEA | GO:0016363 | nuclear matrix |
| CC | IDA | GO:0035097 | histone methyltransferase complex |
| CC | IDA | GO:0044666 | MLL3/4 complex |
| BP | ISS | GO:0000416 | positive regulation of histone H3-K36 methylation |
| BP | IEA | GO:0001570 | vasculogenesis |
| BP | TAS | GO:0006303 | double-strand break repair via nonhomologous end joining |
| BP | IEA | GO:0006310 | DNA recombination |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IDA | GO:0010212 | response to ionizing radiation |
| BP | IMP | GO:0030330 | DNA damage response, signal transduction by p53 class mediator |
| BP | ISS | GO:0031398 | positive regulation of protein ubiquitination |
| BP | ISS | GO:0035066 | positive regulation of histone acetylation |
| BP | IEA | GO:0043542 | endothelial cell migration |
| BP | ISS | GO:0045830 | positive regulation of isotype switching |
| BP | IEA | GO:0048304 | positive regulation of isotype switching to IgG isotypes |
| BP | IDA | GO:0051568 | histone H3-K4 methylation |
| BP | ISS | GO:0051571 | positive regulation of histone H3-K4 methylation |
| BP | IMP | GO:0060261 | positive regulation of transcription initiation from RNA polymerase II promoter |
| BP | ISS | GO:0060261 | positive regulation of transcription initiation from RNA polymerase II promoter |
| BP | IEA | GO:0060612 | adipose tissue development |
| BP | IEA | GO:0060717 | chorion development |
| BP | IEA | GO:1902749 | regulation of cell cycle G2/M phase transition |
| BP | IEA | GO:2001022 | positive regulation of response to DNA damage stimulus |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: PAXIP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PAXIP1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| reactome | R-HSA-5619507 | Activation of HOX genes during differentiation |
| reactome | R-HSA-5693532 | DNA Double-Strand Break Repair |
| reactome | R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) |
| reactome | R-HSA-73894 | DNA Repair |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD297 | Austocystin D | 1 |
| iGMDRD466 | Chaetocin | 4 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD152 | 179324-69-7 | 6 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD494 | Neopeltolide | 4 |
| iGMDRD599 | Salermide | 2 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD441 | TW 37 | 3 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD260 | FQI-2 | 3 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD85 | Ursolic acid | 4 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD584 | VER 155008 | 1 |
| iGMDRD330 | BRD4132 | 2 |
| iGMDRD42 | Vorinostat | 3 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD246 | NPC26 | 4 |
| iGMDRD263 | AACOCF3 | 2 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD289 | Parthenolide | 4 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD103 | SN-38 | 2 |
| iGMDRD121 | GMX1778 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PAXIP1
CLASSFICATION
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