PDCD1
Summary: This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| programmed cell death 1 | MIM:600244 | Ensembl:ENSG00000188389 | HGNC:HGNC:8760 | PA33110 | 2q37.3 |
GO terms in PDCD1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0009897 | external side of plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| BP | IEA | GO:0002644 | negative regulation of tolerance induction |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | TAS | GO:0006959 | humoral immune response |
| BP | TAS | GO:0007275 | multicellular organism development |
| BP | TAS | GO:0031295 | T cell costimulation |
| BP | IEA | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0070234 | positive regulation of T cell apoptotic process |
Gene expression in normal tissue: PDCD1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PDCD1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-388841 | Costimulation by the CD28 family |
| reactome | R-HSA-389948 | PD-1 signaling |
| wikipathways | WP2583 | T-Cell Receptor and Co-stimulatory Signaling |
| wikipathways | WP3863 | T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection |
| kegg | hsa04514 | Cell adhesion molecules (CAMs) - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD701 | NVP-AUY922 | 5 |
| iGMDRD405 | PIK-75 | 4 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD123 | Isoevodiamine | 10 |
| iGMDRD481 | Dactolisib | 3 |
| iGMDRD705 | Nakiterpiosin | 1 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD103 | SN-38 | 2 |
| iGMDRD121 | GMX1778 | 4 |
| iGMDRD137 | Indisulam | 7 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD329 | Merck60 | 4 |
| iGMDRD872 | BRD7137 | 1 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD599 | Salermide | 1 |
| iGMDRD772 | BRD4770 | 1 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD151 | CHM-1 | 7 |
| iGMDRD433 | Lexibulin | 4 |
| iGMDRD280 | CYTOCHALASIN B | 4 |
| iGMDRD466 | Chaetocin | 4 |
| iGMDRD193 | Fqi1 | 6 |
| iGMDRD152 | 179324-69-7 | 5 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD187 | BRD9876 | 4 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD294 | Batimastat | 1 |
| iGMDRD171 | Pemetrexed | 4 |
| iGMDRD802 | 4-methylfasudil | 4 |
| iGMDRD260 | FQI-2 | 6 |
| iGMDRD270 | Ciclosporin | 1 |
| iGMDRD138 | PX 12 | 1 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD451 | Serdemetan | 4 |
| iGMDRD524 | ISX-9 | 4 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD780 | PP-30 | 1 |
| iGMDRD562 | Navitoclax | 4 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD74 | Idarubicin | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PDCD1
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