PAK6
Summary: This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:608110 Ensembl IDEnsembl:ENSG00000137843 HGNC IDHGNC:HGNC:16061 PHARMGKB IDPA32921 Map Location15q15.1 | |||||
GO terms in PAK6
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006355 | regulation of transcription, DNA-templated |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | TAS | GO:0007010 | cytoskeleton organization |
| BP | IBA | GO:0007266 | Rho protein signal transduction |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IBA | GO:0016477 | cell migration |
Gene expression in normal tissue: PAK6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PAK6
Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | agrpathway | agrin in postsynaptic differentiation |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-376176 | Signaling by ROBO receptors |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-428540 | Activation of RAC1 |
| wikipathways | WP138 | Androgen receptor signaling pathway |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PAK6
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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