PAK6
Summary: This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| p21 (RAC1) activated kinase 6 | MIM:608110 | Ensembl:ENSG00000137843 | HGNC:HGNC:16061 | PA32921 | 15q15.1 |
GO terms in PAK6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006355 | regulation of transcription, DNA-templated |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | TAS | GO:0007010 | cytoskeleton organization |
| BP | IBA | GO:0007266 | Rho protein signal transduction |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IBA | GO:0016477 | cell migration |
| BP | IBA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IBA | GO:0030036 | actin cytoskeleton organization |
| BP | IBA | GO:0032147 | activation of protein kinase activity |
| BP | IBA | GO:0043408 | regulation of MAPK cascade |
| CC | IDA | GO:0001650 | fibrillar center |
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0030054 | cell junction |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IBA | GO:0048365 | Rac GTPase binding |
Gene expression in normal tissue: PAK6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PAK6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | agrpathway | agrin in postsynaptic differentiation |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-376176 | Signaling by ROBO receptors |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-428540 | Activation of RAC1 |
| wikipathways | WP138 | Androgen receptor signaling pathway |
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP4205 | MET in type 1 papillary renal cell carcinoma |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa05211 | Renal cell carcinoma - Homo sapiens (human) |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD60 | Quinoclamine | 1 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD2 | PK-11195 | 1 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PAK6
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