RPGRIP1
Summary: This gene encodes a photoreceptor protein that interacts with retinitis pigmentosa GTPase regulator protein and is a key component of cone and rod photoreceptor cells. Mutations in this gene lead to autosomal recessive congenital blindness. [provided by RefSeq, Oct 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| RPGR interacting protein 1 | MIM:605446 | Ensembl:ENSG00000092200 | HGNC:HGNC:13436 | PA34657 | 14q11.2 |
GO terms in RPGRIP1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005930 | axoneme |
| CC | ISS | GO:0032391 | photoreceptor connecting cilium |
| BP | IEA | GO:0007601 | visual perception |
| BP | IEA | GO:0042462 | eye photoreceptor cell development |
| BP | IEA | GO:0050896 | response to stimulus |
| BP | IEA | GO:0060041 | retina development in camera-type eye |
| BP | IEA | GO:0061351 | neural precursor cell proliferation |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: RPGRIP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RPGRIP1
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD730 | Kahalalide F | 3 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD163 | all trans Retinoic Acid | 3 |
| iGMDRD144 | NSC95397 | 5 |
| iGMDRD599 | Salermide | 2 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD76 | Simvastatin | 2 |
| iGMDRD554 | CHEMBL1434137 | 1 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD213 | SMR000068650 | 3 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD883 | CIL55A | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD560 | MK-2206 | 1 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD607 | Ubistatin B | 6 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD330 | BRD4132 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RPGRIP1
CLASSFICATION
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