TLR7
Summary: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| toll like receptor 7 | MIM:300365 | Ensembl:ENSG00000196664 | HGNC:HGNC:15631 | PA38008 | Xp22.2 |
Gene Categories:
DRUGGABLE GENOMEGO terms in TLR7
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0003725 | double-stranded RNA binding |
| MF | ISS | GO:0003727 | single-stranded RNA binding |
| MF | IEA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IEA | GO:0008144 | drug binding |
| MF | IBA | GO:0008329 | signaling pattern recognition receptor activity |
| MF | ISS | GO:0035197 | siRNA binding |
| BP | IEA | GO:0001774 | microglial cell activation |
| BP | IEA | GO:0001932 | regulation of protein phosphorylation |
| BP | IBA | GO:0002224 | toll-like receptor signaling pathway |
| BP | TAS | GO:0002224 | toll-like receptor signaling pathway |
| BP | IEA | GO:0002755 | MyD88-dependent toll-like receptor signaling pathway |
| BP | IEA | GO:0006954 | inflammatory response |
| BP | IBA | GO:0006955 | immune response |
| BP | IBA | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| BP | IDA | GO:0007252 | I-kappaB phosphorylation |
| BP | IDA | GO:0032722 | positive regulation of chemokine production |
| BP | IBA | GO:0032755 | positive regulation of interleukin-6 production |
| BP | IEA | GO:0032755 | positive regulation of interleukin-6 production |
| BP | IDA | GO:0032757 | positive regulation of interleukin-8 production |
| BP | IBA | GO:0034154 | toll-like receptor 7 signaling pathway |
| BP | TAS | GO:0034162 | toll-like receptor 9 signaling pathway |
| BP | IBA | GO:0045078 | positive regulation of interferon-gamma biosynthetic process |
| BP | IDA | GO:0045078 | positive regulation of interferon-gamma biosynthetic process |
| BP | IEA | GO:0045087 | innate immune response |
| BP | IDA | GO:0045356 | positive regulation of interferon-alpha biosynthetic process |
| BP | IBA | GO:0045359 | positive regulation of interferon-beta biosynthetic process |
| BP | IDA | GO:0045359 | positive regulation of interferon-beta biosynthetic process |
| BP | IBA | GO:0045416 | positive regulation of interleukin-8 biosynthetic process |
| BP | IMP | GO:0045416 | positive regulation of interleukin-8 biosynthetic process |
| BP | IC | GO:0050729 | positive regulation of inflammatory response |
| BP | IBA | GO:0051607 | defense response to virus |
| BP | IMP | GO:0051607 | defense response to virus |
| BP | IEP | GO:0071260 | cellular response to mechanical stimulus |
| BP | IDA | GO:1901224 | positive regulation of NIK/NF-kappaB signaling |
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005764 | lysosome |
| CC | ISS | GO:0005768 | endosome |
| CC | ISS | GO:0005783 | endoplasmic reticulum |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0010008 | endosome membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | ISS | GO:0032009 | early phagosome |
| CC | TAS | GO:0036020 | endolysosome membrane |
| CC | IDA | GO:0043235 | receptor complex |
Gene expression in normal tissue: TLR7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TLR7
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | tollpathway | toll-like receptor pathway |
| reactome | R-HSA-1679131 | Trafficking and processing of endosomal TLR |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP3858 | Toll-like Receptor Signaling |
| wikipathways | WP3877 | Simplified Depiction of MYD88 Distinct Input-Output Pathway |
| wikipathways | WP75 | Toll-like Receptor Signaling Pathway |
| kegg | hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD718 | Pyrvinium pamoate | 3 |
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD84 | Lovastatin acid | 1 |
| iGMDRD150 | RITA | 4 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 6 |
| iGMDRD329 | Merck60 | 6 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD882 | CIL41 | 3 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD322 | FK 866 | 1 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD137 | Indisulam | 6 |
| iGMDRD415 | LE-135 | 3 |
| iGMDRD870 | BRD63610 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TLR7
CLASSFICATION
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