TLR7
Summary: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:300365 Ensembl IDEnsembl:ENSG00000196664 HGNC IDHGNC:HGNC:15631 PHARMGKB IDPA38008 Map LocationXp22.2 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in TLR7
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0003725 | double-stranded RNA binding |
| MF | ISS | GO:0003727 | single-stranded RNA binding |
| MF | IEA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IEA | GO:0008144 | drug binding |
| MF | IBA | GO:0008329 | signaling pattern recognition receptor activity |
| MF | ISS | GO:0035197 | siRNA binding |
Gene expression in normal tissue: TLR7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TLR7
Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | tollpathway | toll-like receptor pathway |
| reactome | R-HSA-1679131 | Trafficking and processing of endosomal TLR |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TLR7
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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