TLR7


Summary: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
toll like receptor 7MIM:300365Ensembl:ENSG00000196664HGNC:HGNC:15631PA38008Xp22.2

Gene Categories:

DRUGGABLE GENOME

GO terms in TLR7


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0003725double-stranded RNA binding
MFISSGO:0003727single-stranded RNA binding
MFIEAGO:0004888transmembrane signaling receptor activity
MFIEAGO:0008144drug binding
MFIBAGO:0008329signaling pattern recognition receptor activity
MFISSGO:0035197siRNA binding
BPIEAGO:0001774microglial cell activation
BPIEAGO:0001932regulation of protein phosphorylation
BPIBAGO:0002224toll-like receptor signaling pathway
BPTASGO:0002224toll-like receptor signaling pathway
BPIEAGO:0002755MyD88-dependent toll-like receptor signaling pathway
BPIEAGO:0006954inflammatory response
BPIBAGO:0006955immune response
BPIBAGO:0007249I-kappaB kinase/NF-kappaB signaling
BPIDAGO:0007252I-kappaB phosphorylation
BPIDAGO:0032722positive regulation of chemokine production
BPIBAGO:0032755positive regulation of interleukin-6 production
BPIEAGO:0032755positive regulation of interleukin-6 production
BPIDAGO:0032757positive regulation of interleukin-8 production
BPIBAGO:0034154toll-like receptor 7 signaling pathway
BPTASGO:0034162toll-like receptor 9 signaling pathway
BPIBAGO:0045078positive regulation of interferon-gamma biosynthetic process
BPIDAGO:0045078positive regulation of interferon-gamma biosynthetic process
BPIEAGO:0045087innate immune response
BPIDAGO:0045356positive regulation of interferon-alpha biosynthetic process
BPIBAGO:0045359positive regulation of interferon-beta biosynthetic process
BPIDAGO:0045359positive regulation of interferon-beta biosynthetic process
BPIBAGO:0045416positive regulation of interleukin-8 biosynthetic process
BPIMPGO:0045416positive regulation of interleukin-8 biosynthetic process
BPICGO:0050729positive regulation of inflammatory response
BPIBAGO:0051607defense response to virus
BPIMPGO:0051607defense response to virus
BPIEPGO:0071260cellular response to mechanical stimulus
BPIDAGO:1901224positive regulation of NIK/NF-kappaB signaling
CCTASGO:0000139Golgi membrane
CCIDAGO:0005737cytoplasm
CCISSGO:0005764lysosome
CCISSGO:0005768endosome
CCISSGO:0005783endoplasmic reticulum
CCTASGO:0005789endoplasmic reticulum membrane
CCIBAGO:0005886plasma membrane
CCIDAGO:0005886plasma membrane
CCTASGO:0010008endosome membrane
CCIEAGO:0016021integral component of membrane
CCISSGO:0032009early phagosome
CCTASGO:0036020endolysosome membrane
CCIDAGO:0043235receptor complex

Gene expression in normal tissue: TLR7

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TLR7


DatabasePathway IDPathway Des.
biocartatollpathwaytoll-like receptor pathway
reactomeR-HSA-1679131Trafficking and processing of endosomal TLR
reactomeR-HSA-168138Toll Like Receptor 9 (TLR9) Cascade
reactomeR-HSA-168181Toll Like Receptor 7/8 (TLR7/8) Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-975110TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
reactomeR-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
reactomeR-HSA-975155MyD88 dependent cascade initiated on endosome
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP3858Toll-like Receptor Signaling
wikipathwaysWP3877Simplified Depiction of MYD88 Distinct Input-Output Pathway
wikipathwaysWP75Toll-like Receptor Signaling Pathway
kegghsa04620Toll-like receptor signaling pathway - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD718Pyrvinium pamoate3
iGMDRD237ABT-7511
iGMDRD446LY 21832404
iGMDRD634SCHEMBL26080412
iGMDRD901ELCPK3
iGMDRD177Teniposide3
iGMDRD280CYTOCHALASIN B3
iGMDRD387CHIR-990211
iGMDRD84Lovastatin acid1
iGMDRD150RITA4
iGMDRD345Compound 10b [PMID: 11504634]6
iGMDRD329Merck606
iGMDRD871BRD63682
iGMDRD188Piperlongumine3
iGMDRD882CIL413
iGMDRD399Selumetinib3
iGMDRD356PNU-746543
iGMDRD524ISX-93
iGMDRD322FK 8661
iGMDRD64Parbendazole3
iGMDRD60Quinoclamine2
iGMDRD5Tyrphostin AG 14783
iGMDRD121GMX17783
iGMDRD137Indisulam6
iGMDRD415LE-1353
iGMDRD870BRD636103

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TLR7

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