EPHA6
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| EPH receptor A6 | MIM:600066 | Ensembl:ENSG00000080224 | HGNC:HGNC:19296 | PA134866684 | 3q11.2 |
GO terms in EPHA6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | ND | GO:0005575 | cellular_component |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0043005 | neuron projection |
| CC | IBA | GO:0043235 | receptor complex |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | ND | GO:0008150 | biological_process |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IBA | GO:0033674 | positive regulation of kinase activity |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | IBA | GO:0043410 | positive regulation of MAPK cascade |
| BP | TAS | GO:0048013 | ephrin receptor signaling pathway |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| MF | ND | GO:0003674 | molecular_function |
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IEA | GO:0005003 | ephrin receptor activity |
| MF | IBA | GO:0005005 | transmembrane-ephrin receptor activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
Gene expression in normal tissue: EPHA6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EPHA6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| pid | epha_fwdpathway | EPHA forward signaling |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-3928663 | EPHA-mediated growth cone collapse |
| reactome | R-HSA-3928663 | EPHA-mediated growth cone collapse |
| reactome | R-HSA-3928665 | EPH-ephrin mediated repulsion of cells |
| reactome | R-HSA-3928665 | EPH-ephrin mediated repulsion of cells |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD23 | Gossypol | 7 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD369 | TGX-115 | 1 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD224 | Necrostatin-1 | 3 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD730 | Kahalalide F | 1 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD52 | Rotenone | 5 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 4 |
| iGMDRD247 | Blebbistatin | 4 |
| iGMDRD513 | BML-259 | 2 |
| iGMDRD394 | BX-795 | 4 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD427 | ABT737 | 1 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD889 | Compound 7d-cis | 1 |
| iGMDRD147 | Prima-1 | 2 |
| iGMDRD329 | Merck60 | 5 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD213 | SMR000068650 | 4 |
| iGMDRD5 | Tyrphostin AG 1478 | 1 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD158 | NSC141540 | 5 |
| iGMDRD103 | SN-38 | 4 |
| iGMDRD219 | Bax channel blocker | 3 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD268 | Cerulenin | 4 |
| iGMDRD60 | Quinoclamine | 4 |
| iGMDRD690 | PRIMA-1MET | 4 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD577 | BIX01294 | 4 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD318 | PAC-1 | 5 |
| iGMDRD802 | 4-methylfasudil | 4 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD380 | Pifithrin-alpha | 4 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD634 | SCHEMBL2608041 | 4 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD201 | SKI II | 1 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD494 | Neopeltolide | 1 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD772 | BRD4770 | 4 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD42 | Vorinostat | 3 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD267 | Oligomycin A | 4 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD116 | CD437 | 2 |
| iGMDRD148 | Pifithrin-mu | 2 |
| iGMDRD607 | Ubistatin B | 4 |
| iGMDRD512 | nutlin 3 | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EPHA6
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.