ZNF331
Summary: This gene encodes a zinc finger protein containing a KRAB (Kruppel-associated box) domain found in transcriptional repressors. This gene may be methylated and silenced in cancer cells. This gene is located within a differentially methylated region (DMR) and shows allele-specific expression in placenta. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding the same protein. [provided by RefSeq, Nov 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| zinc finger protein 331 | MIM:606043 | Ensembl:ENSG00000130844 | HGNC:HGNC:15489 | PA134866703 | 19q13.42 |
GO terms in ZNF331
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0003677 | DNA binding |
| MF | NAS | GO:0008270 | zinc ion binding |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
| CC | IEA | GO:0005634 | nucleus |
Gene expression in normal tissue: ZNF331
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ZNF331
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD901 | ELCPK | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD237 | ABT-751 | 5 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD560 | MK-2206 | 1 |
| iGMDRD150 | RITA | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD512 | nutlin 3 | 4 |
| iGMDRD505 | Pevonedistat | 4 |
| iGMDRD263 | AACOCF3 | 3 |
| iGMDRD552 | AZD-1775 | 2 |
| iGMDRD329 | Merck60 | 7 |
| iGMDRD871 | BRD6368 | 4 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD414 | MST-312 | 4 |
| iGMDRD872 | BRD7137 | 4 |
| iGMDRD231 | Importazole | 4 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD251 | ML162 | 5 |
| iGMDRD202 | Curcumin | 6 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD193 | Fqi1 | 5 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD144 | NSC95397 | 4 |
| iGMDRD387 | CHIR-99021 | 2 |
| iGMDRD433 | Lexibulin | 5 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD64 | Parbendazole | 5 |
| iGMDRD888 | Compound 44 | 2 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD188 | Piperlongumine | 6 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD782 | DC-45-A2 | 5 |
| iGMDRD260 | FQI-2 | 2 |
| iGMDRD255 | SB225002 | 8 |
| iGMDRD480 | KU0060648 | 2 |
| iGMDRD138 | PX 12 | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ZNF331
CLASSFICATION
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