ZNF331


Summary: This gene encodes a zinc finger protein containing a KRAB (Kruppel-associated box) domain found in transcriptional repressors. This gene may be methylated and silenced in cancer cells. This gene is located within a differentially methylated region (DMR) and shows allele-specific expression in placenta. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding the same protein. [provided by RefSeq, Nov 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
zinc finger protein 331MIM:606043Ensembl:ENSG00000130844HGNC:HGNC:15489PA13486670319q13.42

GO terms in ZNF331


Term TypeEvidence TypeGO Term IDGO Des.
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0003677DNA binding
MFNASGO:0008270zinc ion binding
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006357regulation of transcription by RNA polymerase II
CCIEAGO:0005634nucleus

Gene expression in normal tissue: ZNF331

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ZNF331


DatabasePathway IDPathway Des.
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD901ELCPK2
iGMDRD211(1S,3R)-RSL32
iGMDRD123Isoevodiamine4
iGMDRD351GW843682X3
iGMDRD237ABT-7515
iGMDRD405PIK-752
iGMDRD560MK-22061
iGMDRD150RITA3
iGMDRD345Compound 10b [PMID: 11504634]2
iGMDRD512nutlin 34
iGMDRD505Pevonedistat4
iGMDRD263AACOCF33
iGMDRD552AZD-17752
iGMDRD329Merck607
iGMDRD871BRD63684
iGMDRD286Nsc 6328394
iGMDRD414MST-3124
iGMDRD872BRD71374
iGMDRD231Importazole4
iGMDRD705Nakiterpiosin3
iGMDRD103SN-383
iGMDRD137Indisulam3
iGMDRD251ML1625
iGMDRD202Curcumin6
iGMDRD297Austocystin D2
iGMDRD639YK 4-2793
iGMDRD61Kinetin riboside4
iGMDRD152179324-69-71
iGMDRD193Fqi15
iGMDRD446LY 21832403
iGMDRD670ML 2103
iGMDRD144NSC953974
iGMDRD387CHIR-990212
iGMDRD433Lexibulin5
iGMDRD151CHM-13
iGMDRD64Parbendazole5
iGMDRD888Compound 442
iGMDRD506Fedratinib2
iGMDRD188Piperlongumine6
iGMDRD399Selumetinib3
iGMDRD187BRD98762
iGMDRD782DC-45-A25
iGMDRD260FQI-22
iGMDRD255SB2250028
iGMDRD480KU00606482
iGMDRD138PX 124

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ZNF331

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