ULK3
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| unc-51 like kinase 3 | MIM:613472 | Ensembl:ENSG00000140474 | HGNC:HGNC:19703 | PA134908392 | 15q24.1 |
GO terms in ULK3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0000407 | phagophore assembly site |
| CC | TAS | GO:0000407 | phagophore assembly site |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005829 | cytosol |
| CC | IBA | GO:0016020 | membrane |
| CC | TAS | GO:0097542 | ciliary tip |
| BP | IBA | GO:0000045 | autophagosome assembly |
| BP | TAS | GO:0006914 | autophagy |
| BP | IBA | GO:0010506 | regulation of autophagy |
| BP | IDA | GO:0045879 | negative regulation of smoothened signaling pathway |
| BP | IDA | GO:0045880 | positive regulation of smoothened signaling pathway |
| BP | IBA | GO:0046777 | protein autophosphorylation |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | TAS | GO:0090398 | cellular senescence |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
Gene expression in normal tissue: ULK3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ULK3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1471 | Target Of Rapamycin (TOR) Signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-5358351 | Signaling by Hedgehog |
| reactome | R-HSA-5632684 | Hedgehog 'on' state |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD513 | BML-259 | 3 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD100 | Zebularine | 4 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 1 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD123 | Isoevodiamine | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ULK3
CLASSFICATION
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