CCR5
Summary: This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| C-C motif chemokine receptor 5 (gene/pseudogene) | MIM:601373 | Ensembl:ENSG00000160791 | HGNC:HGNC:1606 | PA26170 | 3p21.31 |
GO terms in CCR5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEP | GO:0000165 | MAPK cascade |
| BP | TAS | GO:0002407 | dendritic cell chemotaxis |
| BP | IDA | GO:0006816 | calcium ion transport |
| BP | IBA | GO:0006935 | chemotaxis |
| BP | TAS | GO:0006935 | chemotaxis |
| BP | IBA | GO:0006954 | inflammatory response |
| BP | IEA | GO:0006954 | inflammatory response |
| BP | IBA | GO:0006955 | immune response |
| BP | IEA | GO:0006955 | immune response |
| BP | TAS | GO:0006968 | cellular defense response |
| BP | TAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | IMP | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IBA | GO:0007204 | positive regulation of cytosolic calcium ion concentration |
| BP | TAS | GO:0007204 | positive regulation of cytosolic calcium ion concentration |
| BP | IDA | GO:0007267 | cell-cell signaling |
| BP | IDA | GO:0014808 | release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| BP | TAS | GO:0019064 | fusion of virus membrane with host plasma membrane |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IBA | GO:0019722 | calcium-mediated signaling |
| BP | IDA | GO:0019722 | calcium-mediated signaling |
| BP | IEP | GO:0023052 | signaling |
| BP | TAS | GO:0030260 | entry into host cell |
| BP | IBA | GO:0060326 | cell chemotaxis |
| BP | IEA | GO:0070098 | chemokine-mediated signaling pathway |
| BP | IMP | GO:0070723 | response to cholesterol |
| BP | IEP | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IEA | GO:2000110 | negative regulation of macrophage apoptotic process |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005768 | endosome |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0009897 | external side of plasma membrane |
| CC | IDA | GO:0009897 | external side of plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| MF | IEA | GO:0001618 | virus receptor activity |
| MF | IDA | GO:0003779 | actin binding |
| MF | TAS | GO:0004435 | phosphatidylinositol phospholipase C activity |
| MF | TAS | GO:0004950 | chemokine receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0015026 | coreceptor activity |
| MF | IBA | GO:0016493 | C-C chemokine receptor activity |
| MF | IDA | GO:0016493 | C-C chemokine receptor activity |
| MF | NAS | GO:0016493 | C-C chemokine receptor activity |
| MF | IBA | GO:0019956 | chemokine binding |
| MF | IBA | GO:0019957 | C-C chemokine binding |
| MF | IPI | GO:0019957 | C-C chemokine binding |
| MF | IBA | GO:0071791 | chemokine (C-C motif) ligand 5 binding |
| MF | IPI | GO:0071791 | chemokine (C-C motif) ligand 5 binding |
Gene expression in normal tissue: CCR5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CCR5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP117 | GPCRs, Other |
| wikipathways | WP24 | Peptide GPCRs |
| wikipathways | WP4063 | Interleukin-10 signaling |
| wikipathways | WP455 | GPCRs, Class A Rhodopsin-like |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| kegg | hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| pid | il12_2pathway | IL12-mediated signaling events |
| biocarta | barrestinpathway | -arrestins in gpcr desensitization |
| biocarta | barrestinsrcpathway | roles of arrestin dependent recruitment of src kinases in gpcr signaling |
| biocarta | barrmapkpathway | role of -arrestins in the activation and targeting of map kinases |
| biocarta | ccr5pathway | pertussis toxin-insensitive ccr5 signaling in macrophage |
| biocarta | chrebppathway | chrebp regulation by carbohydrates and camp |
| biocarta | cskpathway | activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor |
| biocarta | gspathway | activation of camp-dependent protein kinase pka |
| biocarta | il12pathway | il12 and stat4 dependent signaling pathway in th1 development |
| biocarta | raccpathway | ion channels and their functional role in vascular endothelium |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162587 | HIV Life Cycle |
| reactome | R-HSA-162594 | Early Phase of HIV Life Cycle |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-173107 | Binding and entry of HIV virion |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) |
| reactome | R-HSA-375276 | Peptide ligand-binding receptors |
| reactome | R-HSA-380108 | Chemokine receptors bind chemokines |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-500792 | GPCR ligand binding |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-6783783 | Interleukin-10 signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD202 | Curcumin | 2 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD427 | ABT737 | 4 |
| iGMDRD698 | Neratinib | 2 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD883 | CIL55A | 1 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD246 | NPC26 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CCR5
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