CCR5


Summary: This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in CCR5


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
BP IEP GO:0000165 MAPK cascade
BP TAS GO:0002407 dendritic cell chemotaxis
BP IDA GO:0006816 calcium ion transport
BP IBA GO:0006935 chemotaxis
BP TAS GO:0006935 chemotaxis
BP IBA GO:0006954 inflammatory response
Showing 1 to 6 of 50 rows rows per page

Gene expression in normal tissue: CCR5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined13Stilbenoid, diarylheptanoid and gingerol biosynthesis1WNT signaling1

Pathways in CCR5


Loading, please wait...
Database
Pathway ID
Pathway Des.
wikipathways WP117 GPCRs, Other
wikipathways WP24 Peptide GPCRs
wikipathways WP4063 Interleukin-10 signaling
wikipathways WP455 GPCRs, Class A Rhodopsin-like
wikipathways WP69 T-Cell antigen Receptor (TCR) Signaling Pathway
kegg hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
Showing 1 to 6 of 39 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD387 CHIR-99021 1
iGMDRD579 PF750 2
iGMDRD202 Curcumin 2
iGMDRD434 BMS-536924 2
Showing 1 to 4 of 15 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CCR5

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​