CCR5
Summary: This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:601373 Ensembl IDEnsembl:ENSG00000160791 HGNC IDHGNC:HGNC:1606 PHARMGKB IDPA26170 Map Location3p21.31 |
GO terms in CCR5
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | IEP | GO:0000165 | MAPK cascade |
BP | TAS | GO:0002407 | dendritic cell chemotaxis |
BP | IDA | GO:0006816 | calcium ion transport |
BP | IBA | GO:0006935 | chemotaxis |
BP | TAS | GO:0006935 | chemotaxis |
BP | IBA | GO:0006954 | inflammatory response |
Gene expression in normal tissue: CCR5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CCR5
Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP117 | GPCRs, Other |
wikipathways | WP24 | Peptide GPCRs |
wikipathways | WP4063 | Interleukin-10 signaling |
wikipathways | WP455 | GPCRs, Class A Rhodopsin-like |
wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in CCR5
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |