Summary: This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015].

C-C motif chemokine receptor 5 (gene/pseudogene)MIM:601373Ensembl:ENSG00000160791HGNC:HGNC:1606PA261703p21.31

GO terms in CCR5

Term TypeEvidence TypeGO Term IDGO Des.
BPIEPGO:0000165MAPK cascade
BPTASGO:0002407dendritic cell chemotaxis
BPIDAGO:0006816calcium ion transport
BPIBAGO:0006954inflammatory response
BPIEAGO:0006954inflammatory response
BPIBAGO:0006955immune response
BPIEAGO:0006955immune response
BPTASGO:0006968cellular defense response
BPTASGO:0007166cell surface receptor signaling pathway
BPIMPGO:0007186G-protein coupled receptor signaling pathway
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPIBAGO:0007204positive regulation of cytosolic calcium ion concentration
BPTASGO:0007204positive regulation of cytosolic calcium ion concentration
BPIDAGO:0007267cell-cell signaling
BPIDAGO:0014808release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
BPTASGO:0019064fusion of virus membrane with host plasma membrane
BPTASGO:0019221cytokine-mediated signaling pathway
BPIBAGO:0019722calcium-mediated signaling
BPIDAGO:0019722calcium-mediated signaling
BPTASGO:0030260entry into host cell
BPIBAGO:0060326cell chemotaxis
BPIEAGO:0070098chemokine-mediated signaling pathway
BPIMPGO:0070723response to cholesterol
BPIEPGO:0071222cellular response to lipopolysaccharide
BPIEAGO:2000110negative regulation of macrophage apoptotic process
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCIBAGO:0009897external side of plasma membrane
CCIDAGO:0009897external side of plasma membrane
CCIDAGO:0009986cell surface
MFIEAGO:0001618virus receptor activity
MFIDAGO:0003779actin binding
MFTASGO:0004435phosphatidylinositol phospholipase C activity
MFTASGO:0004950chemokine receptor activity
MFIPIGO:0005515protein binding
MFTASGO:0015026coreceptor activity
MFIBAGO:0016493C-C chemokine receptor activity
MFIDAGO:0016493C-C chemokine receptor activity
MFNASGO:0016493C-C chemokine receptor activity
MFIBAGO:0019956chemokine binding
MFIBAGO:0019957C-C chemokine binding
MFIPIGO:0019957C-C chemokine binding
MFIBAGO:0071791chemokine (C-C motif) ligand 5 binding
MFIPIGO:0071791chemokine (C-C motif) ligand 5 binding

Gene expression in normal tissue: CCR5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CCR5

DatabasePathway IDPathway Des.
wikipathwaysWP117GPCRs, Other
wikipathwaysWP24Peptide GPCRs
wikipathwaysWP4063Interleukin-10 signaling
wikipathwaysWP455GPCRs, Class A Rhodopsin-like
wikipathwaysWP69T-Cell antigen Receptor (TCR) Signaling Pathway
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04144Endocytosis - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
pidil12_2pathwayIL12-mediated signaling events
biocartabarrestinpathway-arrestins in gpcr desensitization
biocartabarrestinsrcpathwayroles of arrestin dependent recruitment of src kinases in gpcr signaling
biocartabarrmapkpathwayrole of -arrestins in the activation and targeting of map kinases
biocartaccr5pathwaypertussis toxin-insensitive ccr5 signaling in macrophage
biocartachrebppathwaychrebp regulation by carbohydrates and camp
biocartacskpathwayactivation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor
biocartagspathwayactivation of camp-dependent protein kinase pka
biocartail12pathwayil12 and stat4 dependent signaling pathway in th1 development
biocartaraccpathwayion channels and their functional role in vascular endothelium
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162587HIV Life Cycle
reactomeR-HSA-162594Early Phase of HIV Life Cycle
reactomeR-HSA-162906HIV Infection
reactomeR-HSA-168256Immune System
reactomeR-HSA-173107Binding and entry of HIV virion
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373076Class A/1 (Rhodopsin-like receptors)
reactomeR-HSA-375276Peptide ligand-binding receptors
reactomeR-HSA-380108Chemokine receptors bind chemokines
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-500792GPCR ligand binding
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-6783783Interleukin-10 signaling

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD345Compound 10b [PMID: 11504634]2
iGMDRD446LY 21832402
iGMDRD887Compound 23 citrate2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CCR5