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CNOT6

Summary: This gene encodes the catalytic component of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substrates. The CCR4-NOT complex plays a role in many cellular processes, including miRNA-mediated repression, mRNA degradation, and transcriptional regulation. [provided by RefSeq, Dec 2014].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameCCR4-NOT transcription complex subunit 6 OMIM IDMIM:608951 Ensembl IDEnsembl:ENSG00000113300 HGNC IDHGNC:HGNC:14099 PHARMGKB IDPA26677 Map Location5q35.3

Gene Categories:

TRANSCRIPTION FACTOR COMPLEX ION CHANNEL PROTEASE KINASE LIPID KINASE TYROSINE KINASE G PROTEIN COUPLED RECEPTOR HORMONE ACTIVITY ABC TRANSPORTER NEUTRAL ZINC METALLOPEPTIDASE RNA DIRECTED DNA POLYMERASE DNA REPAIR PHOSPHOLIPASE PROTEIN PHOSPHATASE TRANSPORTER GROWTH FACTOR NUCLEAR HORMONE RECEPTOR DRUG METABOLISM CELL SURFACE TRANSCRIPTION FACTOR BINDING TUMOR SUPPRESSOR DRUG RESISTANCE SERINE THREONINE KINASE EXTERNAL SIDE OF PLASMA MEMBRANE PROTEASE INHIBITOR DRUGGABLE GENOME HISTONE MODIFICATION

GO terms in CNOT6

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	IMP	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
BP	TAS	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
BP	IEA	GO:0006351	transcription, DNA-templated
BP	IEA	GO:0006355	regulation of transcription, DNA-templated
BP	IEA	GO:0006417	regulation of translation
BP	TAS	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

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Gene expression in normal tissue: CNOT6

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CNOT6

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-212436	Generic Transcription Pathway
reactome	R-HSA-3700989	Transcriptional Regulation by TP53
reactome	R-HSA-429914	Deadenylation-dependent mRNA decay
reactome	R-HSA-429947	Deadenylation of mRNA
reactome	R-HSA-5617472	Activation of anterior HOX genes in hindbrain development during early embryogenesis

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD901	ELCPK	3
iGMDRD123	Isoevodiamine	3
iGMDRD639	YK 4-279	3
iGMDRD351	GW843682X	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CNOT6

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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