CNOT6
Summary: This gene encodes the catalytic component of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substrates. The CCR4-NOT complex plays a role in many cellular processes, including miRNA-mediated repression, mRNA degradation, and transcriptional regulation. [provided by RefSeq, Dec 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| CCR4-NOT transcription complex subunit 6 | MIM:608951 | Ensembl:ENSG00000113300 | HGNC:HGNC:14099 | PA26677 | 5q35.3 |
Gene Categories:
TRANSCRIPTION FACTOR COMPLEXION CHANNELPROTEASEKINASELIPID KINASETYROSINE KINASEG PROTEIN COUPLED RECEPTORHORMONE ACTIVITYABC TRANSPORTERNEUTRAL ZINC METALLOPEPTIDASERNA DIRECTED DNA POLYMERASEDNA REPAIRPHOSPHOLIPASEPROTEIN PHOSPHATASETRANSPORTERGROWTH FACTORNUCLEAR HORMONE RECEPTORDRUG METABOLISMCELL SURFACETRANSCRIPTION FACTOR BINDINGTUMOR SUPPRESSORDRUG RESISTANCESERINE THREONINE KINASEEXTERNAL SIDE OF PLASMA MEMBRANEPROTEASE INHIBITORDRUGGABLE GENOMEHISTONE MODIFICATIONGO terms in CNOT6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening |
| BP | TAS | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IEA | GO:0006417 | regulation of translation |
| BP | TAS | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | IMP | GO:0010606 | positive regulation of cytoplasmic mRNA processing body assembly |
| BP | TAS | GO:0035195 | gene silencing by miRNA |
| BP | IDA | GO:0043928 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay |
| BP | IMP | GO:0070966 | nuclear-transcribed mRNA catabolic process, no-go decay |
| BP | IEA | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic |
| BP | IDA | GO:2000327 | positive regulation of nuclear receptor transcription coactivator activity |
| CC | IEA | GO:0005634 | nucleus |
| CC | TAS | GO:0005829 | cytosol |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0030014 | CCR4-NOT complex |
| MF | IEA | GO:0003723 | RNA binding |
| MF | IDA | GO:0004532 | exoribonuclease activity |
| MF | IDA | GO:0004535 | poly(A)-specific ribonuclease activity |
| MF | TAS | GO:0004535 | poly(A)-specific ribonuclease activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: CNOT6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CNOT6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-429914 | Deadenylation-dependent mRNA decay |
| reactome | R-HSA-429947 | Deadenylation of mRNA |
| reactome | R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| reactome | R-HSA-5619507 | Activation of HOX genes during differentiation |
| reactome | R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes |
| reactome | R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| kegg | hsa03018 | RNA degradation - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD901 | ELCPK | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD444 | Tivantinib | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD730 | Kahalalide F | 3 |
| iGMDRD137 | Indisulam | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CNOT6
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.