FLNC
Summary: This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| filamin C | MIM:102565 | Ensembl:ENSG00000128591 | HGNC:HGNC:3756 | PA28174 | 7q32.1 |
GO terms in FLNC
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0034329 | cell junction assembly |
| BP | IEA | GO:0048747 | muscle fiber development |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005856 | cytoskeleton |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IEA | GO:0016528 | sarcoplasm |
| CC | IEA | GO:0030018 | Z disc |
| CC | IDA | GO:0042383 | sarcolemma |
| CC | TAS | GO:0043034 | costamere |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008092 | cytoskeletal protein binding |
| MF | IPI | GO:0030506 | ankyrin binding |
| MF | IEA | GO:0051015 | actin filament binding |
Gene expression in normal tissue: FLNC
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FLNC
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa05132 | Salmonella infection - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP382 | MAPK Signaling Pathway |
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-446353 | Cell-extracellular matrix interactions |
| reactome | R-HSA-446728 | Cell junction organization |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD494 | Neopeltolide | 1 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD210 | AC55649 | 2 |
| iGMDRD76 | Simvastatin | 2 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD193 | Fqi1 | 4 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD171 | Pemetrexed | 4 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD802 | 4-methylfasudil | 1 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD138 | PX 12 | 5 |
| iGMDRD270 | Ciclosporin | 3 |
| iGMDRD524 | ISX-9 | 6 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD64 | Parbendazole | 6 |
| iGMDRD562 | Navitoclax | 5 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD100 | Zebularine | 5 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD523 | Cyanoquinoline, 11 | 5 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 7 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD330 | BRD4132 | 2 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD435 | BI-2536 | 6 |
| iGMDRD945 | ML214 | 4 |
| iGMDRD123 | Isoevodiamine | 5 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD237 | ABT-751 | 6 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD698 | Neratinib | 1 |
| iGMDRD85 | Ursolic acid | 5 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD289 | Parthenolide | 4 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD137 | Indisulam | 10 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD42 | Vorinostat | 2 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD886 | Compound 1541A | 1 |
| iGMDRD300 | Tozasertib | 9 |
| iGMDRD329 | Merck60 | 8 |
| iGMDRD286 | Nsc 632839 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FLNC
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.