NOTCH3


Summary: This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
notch 3MIM:600276Ensembl:ENSG00000074181HGNC:HGNC:7883PA3168519p13.12

GO terms in NOTCH3


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
MFIEAGO:0019899enzyme binding
MFIMPGO:0038023signaling receptor activity
MFIPIGO:0042802identical protein binding
MFHDAGO:0045296cadherin binding
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
BPTASGO:0006367transcription initiation from RNA polymerase II promoter
BPTASGO:0007219Notch signaling pathway
BPTASGO:0007221positive regulation of transcription of Notch receptor target
BPIEAGO:0030900forebrain development
BPIEAGO:0045665negative regulation of neuron differentiation
BPTASGO:0045746negative regulation of Notch signaling pathway
BPIEAGO:0048661positive regulation of smooth muscle cell proliferation
BPIEAGO:0048663neuron fate commitment
BPIEAGO:0048844artery morphogenesis
BPIEAGO:0072104glomerular capillary formation
CCTASGO:0000139Golgi membrane
CCTASGO:0005576extracellular region
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCTASGO:0005789endoplasmic reticulum membrane
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIDAGO:0015629actin cytoskeleton
CCIEAGO:0016021integral component of membrane
CCIDAGO:0043235receptor complex

Gene expression in normal tissue: NOTCH3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NOTCH3


DatabasePathway IDPathway Des.
reactomeR-HSA-157118Signaling by NOTCH
reactomeR-HSA-157118Signaling by NOTCH
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-1912399Pre-NOTCH Processing in the Endoplasmic Reticulum
reactomeR-HSA-1912408Pre-NOTCH Transcription and Translation
reactomeR-HSA-1912420Pre-NOTCH Processing in Golgi
reactomeR-HSA-1912420Pre-NOTCH Processing in Golgi
reactomeR-HSA-1912422Pre-NOTCH Expression and Processing
reactomeR-HSA-1912422Pre-NOTCH Expression and Processing
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-350054Notch-HLH transcription pathway
reactomeR-HSA-3781865Diseases of glycosylation
reactomeR-HSA-3906995Diseases associated with O-glycosylation of proteins
reactomeR-HSA-5083630Defective LFNG causes SCDO3
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-9012852Signaling by NOTCH3
reactomeR-HSA-9012852Signaling by NOTCH3
reactomeR-HSA-9013507NOTCH3 Activation and Transmission of Signal to the Nucleus
reactomeR-HSA-9013507NOTCH3 Activation and Transmission of Signal to the Nucleus
reactomeR-HSA-9013508NOTCH3 Intracellular Domain Regulates Transcription
reactomeR-HSA-9013508NOTCH3 Intracellular Domain Regulates Transcription
reactomeR-HSA-9017802Noncanonical activation of NOTCH3
pidnotch_pathwayNotch signaling pathway
netpathPathway_NotchNotch
kegghsa04330Notch signaling pathway - Homo sapiens (human)
kegghsa04371Apelin signaling pathway - Homo sapiens (human)
kegghsa04658Th1 and Th2 cell differentiation - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
wikipathwaysWP2064Neural Crest Differentiation
wikipathwaysWP268Notch Signaling Pathway
wikipathwaysWP2786Pre-NOTCH Expression and Processing
wikipathwaysWP3845Canonical and Non-canonical Notch signaling
wikipathwaysWP3971Role of Osx and miRNAs in tooth development
wikipathwaysWP4239EMT transition in Colorectal Cancer
wikipathwaysWP4242Notch Signaling Pathway
wikipathwaysWP61Notch Signaling Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD494Neopeltolide4
iGMDRD781Sirolimus6
iGMDRD549Ibrutinib (PCI-32765)1
iGMDRD599Salermide4
iGMDRD420Leucascandrolide A5
iGMDRD126Tipifarnib3
iGMDRD151CHM-12
iGMDRD679Bistramide A2
iGMDRD466Chaetocin2
iGMDRD718Pyrvinium pamoate2
iGMDRD446LY 21832403
iGMDRD498GW441756X1
iGMDRD441TW 373
iGMDRD318PAC-15
iGMDRD294Batimastat1
iGMDRD870BRD636103
iGMDRD356PNU-746541
iGMDRD451Serdemetan2
iGMDRD64Parbendazole3
iGMDRD506Fedratinib3
iGMDRD577BIX012941
iGMDRD398Sepantronium3
iGMDRD562Navitoclax3
iGMDRD325Belinostat1
iGMDRD399Selumetinib2
iGMDRD473GDC-08791
iGMDRD887Compound 23 citrate2
iGMDRD79Gemcitabine5
iGMDRD116CD4372
iGMDRD345Compound 10b [PMID: 11504634]6
iGMDRD512nutlin 32
iGMDRD154NSC237663
iGMDRD435BI-25361
iGMDRD123Isoevodiamine3
iGMDRD177Teniposide6
iGMDRD351GW843682X4
iGMDRD57Chloropentafluorobenzene2
iGMDRD314Tanespimycin2
iGMDRD105Triptolide5
iGMDRD103SN-385
iGMDRD137Indisulam2
iGMDRD158NSC1415405
iGMDRD271Brefeldin A2
iGMDRD505Pevonedistat2
iGMDRD300Tozasertib5
iGMDRD552AZD-17752
iGMDRD329Merck602
iGMDRD286Nsc 6328393
iGMDRD664Dinaciclib1
iGMDRD871BRD63681

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NOTCH3

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