TRIB1
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| tribbles pseudokinase 1 | MIM:609461 | Ensembl:ENSG00000173334 | HGNC:HGNC:16891 | PA134963922 | 8q24.13 |
GO terms in TRIB1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IMP | GO:0004860 | protein kinase inhibitor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0005524 | ATP binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| MF | IDA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| MF | ISS | GO:0031625 | ubiquitin protein ligase binding |
| MF | ISS | GO:0055106 | ubiquitin-protein transferase regulator activity |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | IMP | GO:0006469 | negative regulation of protein kinase activity |
| BP | IMP | GO:0007254 | JNK cascade |
| BP | IMP | GO:0014912 | negative regulation of smooth muscle cell migration |
| BP | IMP | GO:0031665 | negative regulation of lipopolysaccharide-mediated signaling pathway |
| BP | IBA | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | ISS | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | IMP | GO:0032496 | response to lipopolysaccharide |
| BP | ISS | GO:0032496 | response to lipopolysaccharide |
| BP | IBA | GO:0043405 | regulation of MAP kinase activity |
| BP | IDA | GO:0043405 | regulation of MAP kinase activity |
| BP | IMP | GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| BP | ISS | GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| BP | IEA | GO:0045645 | positive regulation of eosinophil differentiation |
| BP | IEA | GO:0045651 | positive regulation of macrophage differentiation |
| BP | IEA | GO:0045659 | negative regulation of neutrophil differentiation |
| BP | IMP | GO:0048662 | negative regulation of smooth muscle cell proliferation |
Gene expression in normal tissue: TRIB1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TRIB1
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD466 | Chaetocin | 1 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD387 | CHIR-99021 | 3 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD425 | ERASTIN | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD100 | Zebularine | 4 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD690 | PRIMA-1MET | 3 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
| iGMDRD294 | Batimastat | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 1 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD607 | Ubistatin B | 3 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 1 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD220 | fumonisin B1 | 3 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD213 | SMR000068650 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TRIB1
CLASSFICATION
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