TCF7L1
Summary: This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence. [provided by RefSeq, Nov 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| transcription factor 7 like 1 | MIM:604652 | Ensembl:ENSG00000152284 | HGNC:HGNC:11640 | PA36393 | 2p11.2 |
Gene Categories:
TRANSCRIPTION FACTOR COMPLEXGO terms in TCF7L1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0003677 | DNA binding |
| MF | IBA | GO:0003682 | chromatin binding |
| MF | IBA | GO:0003700 | DNA-binding transcription factor activity |
| MF | NAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IBA | GO:0008013 | beta-catenin binding |
| MF | IBA | GO:0043565 | sequence-specific DNA binding |
| MF | IBA | GO:0044212 | transcription regulatory region DNA binding |
| BP | NAS | GO:0006325 | chromatin organization |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IBA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | NAS | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0016055 | Wnt signaling pathway |
| BP | IBA | GO:0022008 | neurogenesis |
| BP | NAS | GO:0030111 | regulation of Wnt signaling pathway |
| BP | IBA | GO:0048699 | generation of neurons |
| BP | IBA | GO:0060070 | canonical Wnt signaling pathway |
| BP | TAS | GO:1904837 | beta-catenin-TCF complex assembly |
| CC | NAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005667 | transcription factor complex |
| CC | IDA | GO:0005829 | cytosol |
Gene expression in normal tissue: TCF7L1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TCF7L1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-195253 | Degradation of beta-catenin by the destruction complex |
| reactome | R-HSA-195253 | Degradation of beta-catenin by the destruction complex |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex |
| reactome | R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex |
| reactome | R-HSA-3858494 | Beta-catenin independent WNT signaling |
| reactome | R-HSA-4086398 | Ca2+ pathway |
| reactome | R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters |
| reactome | R-HSA-4641265 | Repression of WNT target genes |
| reactome | R-HSA-4641265 | Repression of WNT target genes |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878159 | Transcriptional regulation by RUNX3 |
| reactome | R-HSA-8951430 | RUNX3 regulates WNT signaling |
| pid | betacatenin_nuc_pathway | Regulation of nuclear beta catenin signaling and target gene transcription |
| pid | deltanp63pathway | Validated transcriptional targets of deltaNp63 isoforms |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| kegg | hsa04520 | Adherens junction - Homo sapiens (human) |
| kegg | hsa04916 | Melanogenesis - Homo sapiens (human) |
| kegg | hsa04934 | Cushing,s syndrome - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05210 | Colorectal cancer - Homo sapiens (human) |
| kegg | hsa05213 | Endometrial cancer - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| kegg | hsa05216 | Thyroid cancer - Homo sapiens (human) |
| kegg | hsa05217 | Basal cell carcinoma - Homo sapiens (human) |
| kegg | hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
| kegg | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human) |
| wikipathways | WP2064 | Neural Crest Differentiation |
| wikipathways | WP2118 | Arrhythmogenic Right Ventricular Cardiomyopathy |
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP2858 | Ectoderm Differentiation |
| wikipathways | WP3527 | Preimplantation Embryo |
| wikipathways | WP3678 | Amplification and Expansion of Oncogenic Pathways as Metastatic Traits |
| wikipathways | WP3946 | White fat cell differentiation |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| wikipathways | WP4149 | White fat cell differentiation |
| wikipathways | WP4155 | Endometrial cancer |
| wikipathways | WP4216 | Chromosomal and microsatellite instability in colorectal cancer |
| wikipathways | WP428 | Wnt Signaling Pathway |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD150 | RITA | 2 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 5 |
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD435 | BI-2536 | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD271 | Brefeldin A | 2 |
| iGMDRD415 | LE-135 | 2 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD705 | Nakiterpiosin | 4 |
| iGMDRD366 | PI-103 | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD286 | Nsc 632839 | 5 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD882 | CIL41 | 2 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD634 | SCHEMBL2608041 | 4 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD577 | BIX01294 | 4 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD60 | Quinoclamine | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TCF7L1
CLASSFICATION
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