TCF7L1

Summary: This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence. [provided by RefSeq, Nov 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nametranscription factor 7 like 1
OMIM IDMIM:604652
Ensembl IDEnsembl:ENSG00000152284
HGNC IDHGNC:HGNC:11640
PHARMGKB IDPA36393
Map Location2p11.2

GO terms in TCF7L1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF ISA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF ISM GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF NAS GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF NAS GO:0003677 DNA binding
MF IBA GO:0003682 chromatin binding
MF IBA GO:0003700 DNA-binding transcription factor activity
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Gene expression in normal tissue: TCF7L1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined29Mitosis1One carbon pool by folate1ERK MAPK signaling1DNA replication1Purine metabolism1Cell cycle1PI3K/MTOR signaling1

Pathways in TCF7L1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-195253 Degradation of beta-catenin by the destruction complex
reactome R-HSA-195253 Degradation of beta-catenin by the destruction complex
reactome R-HSA-195721 Signaling by WNT
reactome R-HSA-195721 Signaling by WNT
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD512 nutlin 3 2
iGMDRD79 Gemcitabine 1
iGMDRD150 RITA 2
iGMDRD116 CD437 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TCF7L1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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