JAG1

Summary: The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namejagged 1
OMIM IDMIM:601920
Ensembl IDEnsembl:ENSG00000101384
HGNC IDHGNC:HGNC:6188
PHARMGKB IDPA29986
Map Location20p12.2

GO terms in JAG1


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Term Type
Evidence Type
GO Term ID
GO Des.
CC NAS GO:0005576 extracellular region
CC IDA GO:0005886 plasma membrane
CC TAS GO:0005886 plasma membrane
CC NAS GO:0005887 integral component of plasma membrane
CC ISS GO:0005912 adherens junction
CC IMP GO:0016020 membrane
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Gene expression in normal tissue: JAG1

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 49undefinedtissue: undefined cancer: SMALL_CELL_CARCINOMA model num: 3BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 26LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 20

Gene-drug pathway distribution

undefined24DNA replication2Stilbenoid, diarylheptanoid and gingerol biosynthesis1Chromatin histone acetylation1Apoptosis regulation1

Pathways in JAG1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-157118 Signaling by NOTCH
reactome R-HSA-157118 Signaling by NOTCH
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-1643685 Disease
reactome R-HSA-1980143 Signaling by NOTCH1
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD123 Isoevodiamine 6
iGMDRD297 Austocystin D 2
iGMDRD446 LY 2183240 7
iGMDRD193 Fqi1 4
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in JAG1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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