TNFRSF9 Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008].
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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
GO terms in TNFRSF9
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Term Type
Evidence Type
GO Term ID
GO Des.
BP TAS GO:0006915 apoptotic process BP IEA GO:0008285 negative regulation of cell proliferation BP TAS GO:0033209 tumor necrosis factor-mediated signaling pathway BP IEA GO:0070207 protein homotrimerization BP IEA GO:2001180 negative regulation of interleukin-10 secretion BP IEA GO:2001183 negative regulation of interleukin-12 secretion
Gene expression in normal tissue: TNFRSF9
Select Project:
Transcriptome or Gene expression: PRJEB2445
Transcriptome or Gene expression: PRJEB4337
Transcriptome or Gene expression: PRJNA270632
Transcriptome or Gene expression: PRJNA280600
16 tissues mixture adipose adrenal brain breast colon heart kidney liver lung lymph node ovary prostate skeletal muscle testes thyroid white blood cells Export visualization to SVG
Gene-model tissue-cancer distribution: Bubble Plot undefine tissue: undefine
cancer: undefined
model num: 0 undefined tissue: undefined
cancer: PANCAN
model num: 97 BOWE tissue: BOWE
cancer: BOWEL
model num: 0 BOWEL tissue: BOWEL
cancer: undefined
model num: 20
Export visualization to SVG Gene-drug pathway distribution undefined 35 Apoptosis regulation 2 Metabolism 1 Purine metabolism 1 DNA replication 1 Biosynthesis of secondary metabolites 1 Leukocyte transendothelial migration 1 Proteasome 1
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Gene-Drug: Aster Plot
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Gene in drug-gene network: Network Plot LRRC7 LRRC7 KPNA5 KPNA5 MIEN1 MIEN1 NOTCH1 NOTCH1 EP300 EP300 OBSCN OBSCN ORMDL3 ORMDL3 NYNRIN NYNRIN IL6ST IL6ST KALRN KALRN MYC MYC CSF3 CSF3 RORA RORA ATP13A5 ATP13A5 PDPK1 PDPK1 ZNF331 ZNF331 TAF1L TAF1L ELAVL1 ELAVL1 SB225002 SB225002 HDAC2 HDAC2 CREBBP CREBBP STK11 STK11 KDR KDR ITK ITK MERTK MERTK KDM5A KDM5A NTRK3 NTRK3 PX 12 PX 12 TRPM8 TRPM8 TNFAIP3 TNFAIP3 TRPM7 TRPM7 ARHGEF7 ARHGEF7 TNNI3K TNNI3K FANCD2 FANCD2 BRAF BRAF TTBK1 TTBK1 TP63 TP63 PRKCG PRKCG WAS WAS BUB1 BUB1 GRIA3 GRIA3 BML-259 BML-259 MMP2 MMP2 CXCR4 CXCR4 WDHD1 WDHD1 WNK1 WNK1 FANCA FANCA GSK3A GSK3A GLI1 GLI1 ZNF423 ZNF423 Batimastat Batimastat PGR PGR IKZF1 IKZF1 GUCY1A2 GUCY1A2 NUTM1 NUTM1 NR2F1 NR2F1 PRKX PRKX LAMA1 LAMA1 MAP3K10 MAP3K10 XPO5 XPO5 NIPBL NIPBL RPS6KA5 RPS6KA5 PORCN PORCN EGFR EGFR DYRK2 DYRK2 PTEN PTEN FLNA FLNA DNAAF3 DNAAF3 PBX1 PBX1 TET2 TET2 NF1 NF1 BRD63610 BRD63610 SLC22A3 SLC22A3 ZNF217 ZNF217 ICK ICK PIK3C3 PIK3C3 STK39 STK39 ARHGEF12 ARHGEF12 LZTR1 LZTR1 ML006 ML006 NEK1 NEK1 ARHGAP29 ARHGAP29 AKAP6 AKAP6 MAP2K3 MAP2K3 ADAMTS2 ADAMTS2 DC-45-A2 DC-45-A2 CDC34 CDC34 VRK3 VRK3 PAX7 PAX7 STK38L STK38L CSNK1G3 CSNK1G3 CTNNA2 CTNNA2 FHIT FHIT ZFP69B ZFP69B LMNB2 LMNB2 BRCC3 BRCC3 HBD HBD HORMAD1 HORMAD1 SUZ12 SUZ12 Navitoclax Navitoclax ADCK1 ADCK1 NUP98 NUP98 LMTK2 LMTK2 LGR5 LGR5 MAPK6 MAPK6 SOS1 SOS1 UBR5 UBR5 NR4A3 NR4A3 ERN2 ERN2 RPS6KA2 RPS6KA2 PSKH1 PSKH1 MAPK14 MAPK14 MLKL MLKL STK17B STK17B Sepantronium Sepantronium SHC1 SHC1 KLK7 KLK7 MGA MGA MECOM MECOM CTNNB1 CTNNB1 Idarubicin Idarubicin DHDDS DHDDS NKX2-1 NKX2-1 TENM1 TENM1 LNX2 LNX2 COL4A3BP COL4A3BP PTCH1 PTCH1 HOXD13 HOXD13 BRD4 BRD4 PKN3 PKN3 GHR GHR TNFRSF4 TNFRSF4 Compound 23 citrate Compound 23 citrate MSH6 MSH6 CDK19 CDK19 PI4KA PI4KA KNL1 KNL1 NTRK1 NTRK1 LIFR LIFR MDM2 MDM2 Zebularine Zebularine COPS5 COPS5 MALT1 MALT1 MYCL MYCL CDH11 CDH11 YAP1 YAP1 ROBO2 ROBO2 CLTCL1 CLTCL1 MAP4K2 MAP4K2 MFSD2A MFSD2A PRAME PRAME TGFB1 TGFB1 Piperlongumine Piperlongumine MAP2K4 MAP2K4 ISX-9 ISX-9 PCDH15 PCDH15 MINK1 MINK1 AMER1 AMER1 CNTN5 CNTN5 EPHA6 EPHA6 TRAF6 TRAF6 DST DST HRAS HRAS Gossypol Gossypol SIK2 SIK2 AXIN2 AXIN2 MAST4 MAST4 TEK TEK POU2AF1 POU2AF1 SACS SACS ADAM32 ADAM32 NOTCH2 NOTCH2 PNU-74654 PNU-74654 TTK TTK C1D C1D EPHA3 EPHA3 BRIP1 BRIP1 ERBB4 ERBB4 SMAD4 SMAD4 IL17RD IL17RD PIK3CA PIK3CA CDH2 CDH2 NEK9 NEK9 TOP2A TOP2A Parbendazole Parbendazole ATM ATM FBN2 FBN2 PTPRD PTPRD DNAH8 DNAH8 MTUS2 MTUS2 IFNA2 IFNA2 Leucascandrolide A Leucascandrolide A LTK LTK BRDT BRDT MSH3 MSH3 LATS2 LATS2 YWHAQ YWHAQ PRKD1 PRKD1 DHFR DHFR TMPO TMPO JAK1 JAK1 PF750 PF750 RBL1 RBL1 GTSE1 GTSE1 STK19 STK19 RAP1GDS1 RAP1GDS1 ERN1 ERN1 CARS CARS E2F1 E2F1 EXT1 EXT1 ITPR2 ITPR2 RB1 RB1 KDM6A KDM6A SR-II-138A SR-II-138A CDKL2 CDKL2 P2RX7 P2RX7 N4BP2 N4BP2 KMT2C KMT2C JARID2 JARID2 LRRK2 LRRK2 COL3A1 COL3A1 PDE4DIP PDE4DIP MYLK MYLK FGFR3 FGFR3 Lexibulin Lexibulin KRAS KRAS PRKG2 PRKG2 SMARCA4 SMARCA4 TWF1 TWF1 MRE11 MRE11 FGR FGR GLG1 GLG1 RGL2 RGL2 MAP2K7 MAP2K7 PPP1R3A PPP1R3A STAT6 STAT6 TNN TNN GRIN2B GRIN2B Kinetin riboside Kinetin riboside RBM15 RBM15 ERBB2 ERBB2 BCL11B BCL11B STK4 STK4 TRPS1 TRPS1 179324-69-7 179324-69-7 MYH9 MYH9 MAP3K1 MAP3K1 NCAM1 NCAM1 Fqi1 Fqi1 LRP2 LRP2 COL14A1 COL14A1 SIK3 SIK3 CACNB2 CACNB2 CNTRL CNTRL ALPK2 ALPK2 GRK7 GRK7 JAG1 JAG1 LY 2183240 LY 2183240 SERPINA2 SERPINA2 TRRAP TRRAP RPS6KL1 RPS6KL1 TSC2 TSC2 FANCM FANCM Chaetocin Chaetocin NUP210 NUP210 EPHA7 EPHA7 HERC2 HERC2 STAG3 STAG3 TOX4 TOX4 GMX1778 GMX1778 EPHA2 EPHA2 TNK2 TNK2 SIX4 SIX4 ADGRB1 ADGRB1 FLNC FLNC PIK3CG PIK3CG KIT KIT PIM3 PIM3 Indisulam Indisulam NPR1 NPR1 TPH1 TPH1 FOXP1 FOXP1 P4HB P4HB SN-38 SN-38 ZMYM2 ZMYM2 LMNB1 LMNB1 MARK4 MARK4 LASP1 LASP1 PIP4K2B PIP4K2B FGFR1 FGFR1 TOX3 TOX3 CYFIP1 CYFIP1 CYP2B6 CYP2B6 PTK6 PTK6 WNK2 WNK2 DEK DEK GRK2 GRK2 MAPK10 MAPK10 Triptolide Triptolide ADK ADK PRKCB PRKCB GPR183 GPR183 HOXD10 HOXD10 SMOX SMOX MATK MATK CYP27B1 CYP27B1 DDX1 DDX1 CUBN CUBN RHEB RHEB STK24 STK24 CIITA CIITA Merck60 Merck60 ARID1A ARID1A TSHR TSHR TNFRSF1B TNFRSF1B PDGFRB PDGFRB ADGRG4 ADGRG4 HNF1B HNF1B PKMYT1 PKMYT1 LHFPL6 LHFPL6 CDKL1 CDKL1 BRD7137 BRD7137 ADAMTS20 ADAMTS20 FES FES SRPK2 SRPK2 CTDSPL CTDSPL TAF15 TAF15 TG TG ARAF ARAF Ro 28-1675 Ro 28-1675 RASA3 RASA3 RARA RARA MLH1 MLH1 RPS6KA3 RPS6KA3 ADHFE1 ADHFE1 Nsc 632839 Nsc 632839 FLI1 FLI1 NFKBIA NFKBIA WRN WRN GAK GAK PICALM PICALM MBIP MBIP PKN2 PKN2 STK25 STK25 PARP1 PARP1 EPHA5 EPHA5 FK 866 FK 866 HDAC4 HDAC4 MAML1 MAML1 NFKB1 NFKB1 NPC26 NPC26 EPHA4 EPHA4 UNC13C UNC13C STAC2 STAC2 ACACB ACACB STK40 STK40 TCEA1 TCEA1 TP53 TP53 TIE1 TIE1 PER1 PER1 CD160 CD160 SLC22A15 SLC22A15 IRAK2 IRAK2 Gemcitabine Gemcitabine ITGB8 ITGB8 NOTCH3 NOTCH3 CLPTM1L CLPTM1L TTL TTL PHIP PHIP PRRX1 PRRX1 CEBPA CEBPA TIMP3 TIMP3 SOX10 SOX10 CASP1 CASP1 CSNK1A1 CSNK1A1 CHN1 CHN1 TLR7 TLR7 TRIP11 TRIP11 LOC112268437 LOC112268437 Compound 10b [PMID: 11504634] Compound 10b [PMID: 11504634] HMGA2 HMGA2 IDH1 IDH1 BRCA2 BRCA2 BLK BLK PIK3R4 PIK3R4 ABT-751 ABT-751 ALK ALK UNC79 UNC79 ALDH7A1 ALDH7A1 SGK1 SGK1 TAF1 TAF1 LRP6 LRP6 Ursolic acid Ursolic acid AKT1 AKT1 MAPK7 MAPK7 CSNK1G2 CSNK1G2 TMPRSS2 TMPRSS2 CNTN6 CNTN6 ML214 ML214 CDK20 CDK20 SOX2 SOX2 FMN2 FMN2 PTPRC PTPRC MAP2K5 MAP2K5 CYP24A1 CYP24A1 NLRP3 NLRP3 TRIM42 TRIM42 TET1 TET1 ATRX ATRX POU5F1B POU5F1B AKT3 AKT3 NRK NRK PTPRU PTPRU ERCC6 ERCC6 (-)-gallocatechin-3-O-gallate (-)-gallocatechin-3-O-gallate KCNH2 KCNH2 PDCD1 PDCD1 PAX3 PAX3 LRGUK LRGUK PEAK1 PEAK1 Isoevodiamine Isoevodiamine TNFRSF9 TNFRSF9
Export visualization to SVG Gene-drug targets distribution
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Gene Structure: PDB
