NTRK1
Summary: This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| neurotrophic receptor tyrosine kinase 1 | MIM:191315 | Ensembl:ENSG00000198400 | HGNC:HGNC:8031 | PA31817 | 1q23.1 |
GO terms in NTRK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005768 | endosome |
| CC | ISS | GO:0005769 | early endosome |
| CC | ISS | GO:0005770 | late endosome |
| CC | ISS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0009986 | cell surface |
| CC | IBA | GO:0030424 | axon |
| CC | IEA | GO:0030424 | axon |
| CC | IEA | GO:0030425 | dendrite |
| CC | IEA | GO:0031901 | early endosome membrane |
| CC | IEA | GO:0031902 | late endosome membrane |
| CC | ISS | GO:0032991 | protein-containing complex |
| CC | IEA | GO:0043025 | neuronal cell body |
| CC | IBA | GO:0043235 | receptor complex |
| CC | IDA | GO:0043235 | receptor complex |
| BP | TAS | GO:0000186 | activation of MAPKK activity |
| BP | TAS | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | IEA | GO:0007411 | axon guidance |
| BP | IEA | GO:0007568 | aging |
| BP | IEA | GO:0007611 | learning or memory |
| BP | IEA | GO:0007623 | circadian rhythm |
| BP | IDA | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0009314 | response to radiation |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
| BP | ISS | GO:0010623 | programmed cell death involved in cell development |
| BP | IDA | GO:0010976 | positive regulation of neuron projection development |
| BP | IDA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IEA | GO:0021553 | olfactory nerve development |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IEA | GO:0030183 | B cell differentiation |
| BP | IEA | GO:0031667 | response to nutrient levels |
| BP | IBA | GO:0033674 | positive regulation of kinase activity |
| BP | IMP | GO:0038083 | peptidyl-tyrosine autophosphorylation |
| BP | IMP | GO:0038180 | nerve growth factor signaling pathway |
| BP | IEA | GO:0042490 | mechanoreceptor differentiation |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | TAS | GO:0043066 | negative regulation of apoptotic process |
| BP | ISS | GO:0043068 | positive regulation of programmed cell death |
| BP | IBA | GO:0043410 | positive regulation of MAPK cascade |
| BP | ISS | GO:0043524 | negative regulation of neuron apoptotic process |
| BP | IDA | GO:0043547 | positive regulation of GTPase activity |
| BP | IDA | GO:0046579 | positive regulation of Ras protein signal transduction |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IDA | GO:0048011 | neurotrophin TRK receptor signaling pathway |
| BP | TAS | GO:0048011 | neurotrophin TRK receptor signaling pathway |
| BP | IEA | GO:0048013 | ephrin receptor signaling pathway |
| BP | TAS | GO:0048015 | phosphatidylinositol-mediated signaling |
| BP | ISS | GO:0048485 | sympathetic nervous system development |
| BP | IEA | GO:0048678 | response to axon injury |
| BP | IEA | GO:0050965 | detection of temperature stimulus involved in sensory perception of pain |
| BP | IEA | GO:0050966 | detection of mechanical stimulus involved in sensory perception of pain |
| BP | IDA | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IEA | GO:0051599 | response to hydrostatic pressure |
| BP | IEA | GO:0051602 | response to electrical stimulus |
| BP | IEA | GO:0051965 | positive regulation of synapse assembly |
| BP | IEA | GO:0051968 | positive regulation of synaptic transmission, glutamatergic |
| BP | IEA | GO:0060009 | Sertoli cell development |
| BP | ISS | GO:0060385 | axonogenesis involved in innervation |
| BP | IEA | GO:0061368 | behavioral response to formalin induced pain |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IDA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IEA | GO:0071316 | cellular response to nicotine |
| BP | IDA | GO:1904646 | cellular response to amyloid-beta |
| BP | IBA | GO:1990090 | cellular response to nerve growth factor stimulus |
| BP | IMP | GO:1990090 | cellular response to nerve growth factor stimulus |
| BP | ISS | GO:1990090 | cellular response to nerve growth factor stimulus |
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IDA | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IDA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IMP | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IEA | GO:0005004 | GPI-linked ephrin receptor activity |
| MF | IBA | GO:0005030 | neurotrophin receptor activity |
| MF | IEA | GO:0005166 | neurotrophin p75 receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0010465 | nerve growth factor receptor activity |
| MF | IMP | GO:0010465 | nerve growth factor receptor activity |
| MF | IEA | GO:0019900 | kinase binding |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | IBA | GO:0043121 | neurotrophin binding |
| MF | TAS | GO:0043121 | neurotrophin binding |
| MF | IDA | GO:0048406 | nerve growth factor binding |
Gene expression in normal tissue: NTRK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NTRK1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-167021 | PLC-gamma1 signalling |
| reactome | R-HSA-167044 | Signalling to RAS |
| reactome | R-HSA-169893 | Prolonged ERK activation events |
| reactome | R-HSA-169893 | Prolonged ERK activation events |
| reactome | R-HSA-170968 | Frs2-mediated activation |
| reactome | R-HSA-170968 | Frs2-mediated activation |
| reactome | R-HSA-170984 | ARMS-mediated activation |
| reactome | R-HSA-170984 | ARMS-mediated activation |
| reactome | R-HSA-177504 | Retrograde neurotrophin signalling |
| reactome | R-HSA-177504 | Retrograde neurotrophin signalling |
| reactome | R-HSA-187015 | Activation of TRKA receptors |
| reactome | R-HSA-187015 | Activation of TRKA receptors |
| reactome | R-HSA-187024 | NGF-independant TRKA activation |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-187042 | TRKA activation by NGF |
| reactome | R-HSA-187042 | TRKA activation by NGF |
| reactome | R-HSA-187687 | Signalling to ERKs |
| reactome | R-HSA-187687 | Signalling to ERKs |
| reactome | R-HSA-187706 | Signalling to p38 via RIT and RIN |
| reactome | R-HSA-198203 | PI3K/AKT activation |
| reactome | R-HSA-198203 | PI3K/AKT activation |
| reactome | R-HSA-198745 | Signalling to STAT3 |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| biocarta | erk5pathway | role of erk5 in neuronal survival pathway |
| biocarta | trkapathway | trka receptor signaling pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| kegg | hsa05216 | Thyroid cancer - Homo sapiens (human) |
| kegg | hsa05230 | Central carbon metabolism in cancer - Homo sapiens (human) |
| pid | p73pathway | p73 transcription factor network |
| pid | p75ntrpathway | p75(NTR)-mediated signaling |
| pid | pi3kplctrkpathway | Trk receptor signaling mediated by PI3K and PLC-gamma |
| pid | shp2_pathway | SHP2 signaling |
| pid | trkrpathway | Neurotrophic factor-mediated Trk receptor signaling |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4223 | Ras Signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD123 | Isoevodiamine | 6 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD698 | Neratinib | 3 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD219 | Bax channel blocker | 3 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD100 | Zebularine | 7 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD434 | BMS-536924 | 4 |
| iGMDRD575 | Entrectinib | 2 |
| iGMDRD802 | 4-methylfasudil | 2 |
| iGMDRD970 | Pan-TRK inhibitor | 2 |
| iGMDRD137 | Indisulam | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NTRK1
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.