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FGR

Summary: This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
FGR proto-oncogene, Src family tyrosine kinase	MIM:164940	Ensembl:ENSG00000000938	HGNC:HGNC:3697	PA28135	1p35.3

Gene Categories:

LIPID KINASE TYROSINE KINASE DRUGGABLE GENOME KINASE

GO terms in FGR

Term Type	Evidence Type	GO Term ID	GO Des.
CC	TAS	GO:0005576	extracellular region
CC	IEA	GO:0005743	mitochondrial inner membrane
CC	IEA	GO:0005758	mitochondrial intermembrane space
CC	TAS	GO:0005829	cytosol
CC	IDA	GO:0005856	cytoskeleton
CC	IDA	GO:0005886	plasma membrane
CC	ISS	GO:0005886	plasma membrane
CC	ISS	GO:0015629	actin cytoskeleton
CC	IDA	GO:0016235	aggresome
CC	IBA	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
CC	ISS	GO:0032587	ruffle membrane
CC	TAS	GO:0034774	secretory granule lumen
CC	HDA	GO:0070062	extracellular exosome
BP	TAS	GO:0002768	immune response-regulating cell surface receptor signaling pathway
BP	TAS	GO:0006468	protein phosphorylation
BP	IBA	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
BP	IBA	GO:0007229	integrin-mediated signaling pathway
BP	IMP	GO:0007229	integrin-mediated signaling pathway
BP	ISS	GO:0007229	integrin-mediated signaling pathway
BP	ISS	GO:0008360	regulation of cell shape
BP	TAS	GO:0009615	response to virus
BP	IMP	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
BP	IDA	GO:0018108	peptidyl-tyrosine phosphorylation
BP	IBA	GO:0030154	cell differentiation
BP	ISS	GO:0030335	positive regulation of cell migration
BP	IBA	GO:0038083	peptidyl-tyrosine autophosphorylation
BP	TAS	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
BP	IBA	GO:0042127	regulation of cell proliferation
BP	ISS	GO:0043306	positive regulation of mast cell degranulation
BP	TAS	GO:0043312	neutrophil degranulation
BP	IMP	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
BP	IBA	GO:0045087	innate immune response
BP	ISS	GO:0045088	regulation of innate immune response
BP	ISS	GO:0045859	regulation of protein kinase activity
BP	IDA	GO:0046777	protein autophosphorylation
BP	ISS	GO:0050715	positive regulation of cytokine secretion
BP	ISS	GO:0050764	regulation of phagocytosis
BP	ISS	GO:0050830	defense response to Gram-positive bacterium
MF	IPI	GO:0001784	phosphotyrosine residue binding
MF	ISS	GO:0001784	phosphotyrosine residue binding
MF	EXP	GO:0004713	protein tyrosine kinase activity
MF	IDA	GO:0004713	protein tyrosine kinase activity
MF	IBA	GO:0004715	non-membrane spanning protein tyrosine kinase activity
MF	IDA	GO:0004715	non-membrane spanning protein tyrosine kinase activity
MF	TAS	GO:0004715	non-membrane spanning protein tyrosine kinase activity
MF	IBA	GO:0005102	signaling receptor binding
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding
MF	ISS	GO:0019901	protein kinase binding
MF	ISS	GO:0034987	immunoglobulin receptor binding
MF	IDA	GO:0034988	Fc-gamma receptor I complex binding

Gene expression in normal tissue: FGR

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FGR

Database	Pathway ID	Pathway Des.
wikipathways	WP306	Focal Adhesion
wikipathways	WP3929	Chemokine signaling pathway
pid	alphasynuclein_pathway	Alpha-synuclein signaling
pid	cxcr4_pathway	CXCR4-mediated signaling events
pid	epha_fwdpathway	EPHA forward signaling
pid	ephrinbrevpathway	Ephrin B reverse signaling
pid	glypican_1pathway	Glypican 1 network
pid	il8cxcr1_pathway	IL8- and CXCR1-mediated signaling events
pid	il8cxcr2_pathway	IL8- and CXCR2-mediated signaling events
pid	p38alphabetapathway	Regulation of p38-alpha and p38-beta
pid	pdgfrbpathway	PDGFR-beta signaling pathway
pid	pi3kcipathway	Class I PI3K signaling events
pid	ptp1bpathway	Signaling events mediated by PTP1B
pid	txa2pathway	Thromboxane A2 receptor signaling
kegg	hsa04062	Chemokine signaling pathway - Homo sapiens (human)
kegg	hsa05169	Epstein-Barr virus infection - Homo sapiens (human)
netpath	Pathway_IL6	IL6
netpath	Pathway_KitReceptor	KitReceptor
biocarta	barrestinsrcpathway	roles of arrestin dependent recruitment of src kinases in gpcr signaling
reactome	R-HSA-109582	Hemostasis
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis
reactome	R-HSA-2029481	FCGR activation
reactome	R-HSA-418346	Platelet homeostasis
reactome	R-HSA-432142	Platelet sensitization by LDL
reactome	R-HSA-6798695	Neutrophil degranulation

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD886	Compound 1541A	3
iGMDRD353	PD0325901	1
iGMDRD871	BRD6368	3
iGMDRD286	Nsc 632839	3
iGMDRD887	Compound 23 citrate	3
iGMDRD577	BIX01294	6
iGMDRD562	Navitoclax	3
iGMDRD267	Oligomycin A	2
iGMDRD137	Indisulam	9
iGMDRD679	Bistramide A	6
iGMDRD639	YK 4-279	3
iGMDRD152	179324-69-7	3
iGMDRD61	Kinetin riboside	9
iGMDRD219	Bax channel blocker	3
iGMDRD345	Compound 10b [PMID: 11504634]	3
iGMDRD781	Sirolimus	7
iGMDRD484	Pluripotin	3
iGMDRD126	Tipifarnib	3
iGMDRD889	Compound 7d-cis	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FGR

SITE

DATATYPES

CLASSFICATION

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