STRADB


Summary: This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in STRADB


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IBA GO:0000165 MAPK cascade
BP IEA GO:0000902 cell morphogenesis
BP IDA GO:0006468 protein phosphorylation
BP IDA GO:0006611 protein export from nucleus
BP TAS GO:0007050 cell cycle arrest
BP IBA GO:0007346 regulation of mitotic cell cycle
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Gene expression in normal tissue: STRADB

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in STRADB


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Database
Pathway ID
Pathway Des.
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-165159 mTOR signalling
reactome R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK
wikipathways WP1403 AMP-activated Protein Kinase (AMPK) Signaling
wikipathways WP3595 mir-124 predicted interactions with cell cycle and differentiation
kegg hsa04150 mTOR signaling pathway - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD201 SKI II 2
iGMDRD193 Fqi1 2
iGMDRD61 Kinetin riboside 2
iGMDRD316 N9-Isopropyl-olomoucine 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in STRADB

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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