SOX10
Summary: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SRY-box 10 | MIM:602229 | Ensembl:ENSG00000100146 | HGNC:HGNC:11190 | PA36027 | 22q13.1 |
GO terms in SOX10
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IBA | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| MF | ISS | GO:0003677 | DNA binding |
| MF | ISS | GO:0003700 | DNA-binding transcription factor activity |
| MF | TAS | GO:0003713 | transcription coactivator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008134 | transcription factor binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IEA | GO:1990841 | promoter-specific chromatin binding |
| BP | IBA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0001755 | neural crest cell migration |
| BP | IBA | GO:0002009 | morphogenesis of an epithelium |
| BP | TAS | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006368 | transcription elongation from RNA polymerase II promoter |
| BP | IBA | GO:0007417 | central nervous system development |
| BP | IBA | GO:0007422 | peripheral nervous system development |
| BP | TAS | GO:0009653 | anatomical structure morphogenesis |
| BP | IEA | GO:0010626 | negative regulation of Schwann cell proliferation |
| BP | ISS | GO:0014003 | oligodendrocyte development |
| BP | ISS | GO:0022010 | central nervous system myelination |
| BP | IEA | GO:0031643 | positive regulation of myelination |
| BP | IEA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | ISS | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0048484 | enteric nervous system development |
| BP | IBA | GO:0048709 | oligodendrocyte differentiation |
| BP | ISS | GO:0048709 | oligodendrocyte differentiation |
| BP | IEA | GO:0048863 | stem cell differentiation |
| BP | IEA | GO:0071393 | cellular response to progesterone stimulus |
| CC | IEA | GO:0000785 | chromatin |
| CC | IDA | GO:0005634 | nucleus |
| CC | ISS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005741 | mitochondrial outer membrane |
Gene expression in normal tissue: SOX10
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD316 | N9-Isopropyl-olomoucine | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD177 | Teniposide | 6 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD1008 | SR-II-138A | 1 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD554 | CHEMBL1434137 | 3 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 6 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD596 | Vemurafenib | 1 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD137 | Indisulam | 6 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD782 | DC-45-A2 | 6 |
| iGMDRD434 | BMS-536924 | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SOX10
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