HIPK2


Summary: This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in HIPK2


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
MF ISS GO:0001102 RNA polymerase II activating transcription factor binding
MF ISS GO:0003713 transcription coactivator activity
MF IDA GO:0003714 transcription corepressor activity
MF IDA GO:0004672 protein kinase activity
MF EXP GO:0004674 protein serine/threonine kinase activity
MF ISS GO:0004674 protein serine/threonine kinase activity
Showing 1 to 6 of 57 rows rows per page

Gene expression in normal tissue: HIPK2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HIPK2


Loading, please wait...
Database
Pathway ID
Pathway Des.
wikipathways WP3938 miR-222 in Exercise-Induced Cardiac Growth
kegg hsa04218 Cellular senescence - Homo sapiens (human)
pid cmyb_pathway C-MYB transcription factor network
pid p53regulationpathway p53 pathway
netpath Pathway_EGFR1 EGFR1
reactome R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression
Showing 1 to 6 of 22 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD427 ABT737 5
iGMDRD670 ML 210 3
iGMDRD781 Sirolimus 4
iGMDRD433 Lexibulin 3
Showing 1 to 4 of 40 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HIPK2

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​