HIPK2
Summary: This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:606868 Ensembl IDEnsembl:ENSG00000064393 HGNC IDHGNC:HGNC:14402 PHARMGKB IDPA29291 Map Location7q34 |
GO terms in HIPK2
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | ISS | GO:0001102 | RNA polymerase II activating transcription factor binding |
MF | ISS | GO:0003713 | transcription coactivator activity |
MF | IDA | GO:0003714 | transcription corepressor activity |
MF | IDA | GO:0004672 | protein kinase activity |
MF | EXP | GO:0004674 | protein serine/threonine kinase activity |
MF | ISS | GO:0004674 | protein serine/threonine kinase activity |
Gene expression in normal tissue: HIPK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HIPK2
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Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP3938 | miR-222 in Exercise-Induced Cardiac Growth |
kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
pid | cmyb_pathway | C-MYB transcription factor network |
pid | p53regulationpathway | p53 pathway |
netpath | Pathway_EGFR1 | EGFR1 |
reactome | R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in HIPK2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |