HIPK2
Summary: This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| homeodomain interacting protein kinase 2 | MIM:606868 | Ensembl:ENSG00000064393 | HGNC:HGNC:14402 | PA29291 | 7q34 |
GO terms in HIPK2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0001102 | RNA polymerase II activating transcription factor binding |
| MF | ISS | GO:0003713 | transcription coactivator activity |
| MF | IDA | GO:0003714 | transcription corepressor activity |
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | EXP | GO:0004674 | protein serine/threonine kinase activity |
| MF | ISS | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0046332 | SMAD binding |
| MF | IPI | GO:0046790 | virion binding |
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0001654 | eye development |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0006978 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator |
| BP | IEA | GO:0007179 | transforming growth factor beta receptor signaling pathway |
| BP | IEA | GO:0007224 | smoothened signaling pathway |
| BP | IEA | GO:0007628 | adult walking behavior |
| BP | IEA | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0009952 | anterior/posterior pattern specification |
| BP | IEA | GO:0010842 | retina layer formation |
| BP | ISS | GO:0018105 | peptidyl-serine phosphorylation |
| BP | ISS | GO:0018107 | peptidyl-threonine phosphorylation |
| BP | NAS | GO:0019048 | modulation by virus of host morphology or physiology |
| BP | IEA | GO:0030182 | neuron differentiation |
| BP | ISS | GO:0030218 | erythrocyte differentiation |
| BP | IMP | GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway |
| BP | IMP | GO:0030514 | negative regulation of BMP signaling pathway |
| BP | TAS | GO:0030578 | PML body organization |
| BP | ISS | GO:0032092 | positive regulation of protein binding |
| BP | TAS | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| BP | IEA | GO:0043388 | positive regulation of DNA binding |
| BP | IEA | GO:0043524 | negative regulation of neuron apoptotic process |
| BP | IDA | GO:0045766 | positive regulation of angiogenesis |
| BP | IMP | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | ISS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0046330 | positive regulation of JNK cascade |
| BP | IEA | GO:0048596 | embryonic camera-type eye morphogenesis |
| BP | IEA | GO:0050882 | voluntary musculoskeletal movement |
| BP | ISS | GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| BP | TAS | GO:0051726 | regulation of cell cycle |
| BP | IEA | GO:0060059 | embryonic retina morphogenesis in camera-type eye |
| BP | IEA | GO:0060235 | lens induction in camera-type eye |
| BP | IDA | GO:0060395 | SMAD protein signal transduction |
| BP | IEA | GO:0061072 | iris morphogenesis |
| BP | TAS | GO:0071456 | cellular response to hypoxia |
| BP | NAS | GO:0097193 | intrinsic apoptotic signaling pathway |
| BP | TAS | GO:1901796 | regulation of signal transduction by p53 class mediator |
| BP | IMP | GO:2000059 | negative regulation of ubiquitin-dependent protein catabolic process |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0016604 | nuclear body |
| CC | TAS | GO:0016604 | nuclear body |
| CC | IDA | GO:0016605 | PML body |
| CC | ISS | GO:0090575 | RNA polymerase II transcription factor complex |
Gene expression in normal tissue: HIPK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HIPK2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3938 | miR-222 in Exercise-Induced Cardiac Growth |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| pid | cmyb_pathway | C-MYB transcription factor network |
| pid | p53regulationpathway | p53 pathway |
| netpath | Pathway_EGFR1 | EGFR1 |
| reactome | R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-3899300 | SUMOylation of transcription cofactors |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-397014 | Muscle contraction |
| reactome | R-HSA-5576891 | Cardiac conduction |
| reactome | R-HSA-5578768 | Physiological factors |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD427 | ABT737 | 5 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD781 | Sirolimus | 4 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD889 | Compound 7d-cis | 5 |
| iGMDRD280 | CYTOCHALASIN B | 8 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD193 | Fqi1 | 6 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD294 | Batimastat | 3 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD64 | Parbendazole | 6 |
| iGMDRD524 | ISX-9 | 1 |
| iGMDRD598 | QS-11 | 3 |
| iGMDRD23 | Gossypol | 4 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD730 | Kahalalide F | 3 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD150 | RITA | 2 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD248 | BRD4354 | 3 |
| iGMDRD148 | Pifithrin-mu | 2 |
| iGMDRD512 | nutlin 3 | 6 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD237 | ABT-751 | 5 |
| iGMDRD314 | Tanespimycin | 1 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD202 | Curcumin | 1 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD552 | AZD-1775 | 1 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD286 | Nsc 632839 | 5 |
| iGMDRD329 | Merck60 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HIPK2
CLASSFICATION
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