VRK1
Summary: This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| vaccinia related kinase 1 | MIM:602168 | Ensembl:ENSG00000100749 | HGNC:HGNC:12718 | PA37330 | 14q32.2 |
GO terms in VRK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0031493 | nucleosomal histone binding |
| MF | IDA | GO:0035175 | histone kinase activity (H3-S10 specific) |
| MF | IDA | GO:0072354 | histone kinase activity (H3-T3 specific) |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007077 | mitotic nuclear envelope disassembly |
| BP | TAS | GO:0007084 | mitotic nuclear envelope reassembly |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0043987 | histone H3-S10 phosphorylation |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IEA | GO:0051301 | cell division |
| BP | IDA | GO:0072355 | histone H3-T3 phosphorylation |
| BP | IDA | GO:0090166 | Golgi disassembly |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005795 | Golgi stack |
| CC | IEA | GO:0005819 | spindle |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
Gene expression in normal tissue: VRK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in VRK1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-2555396 | Mitotic Metaphase and Anaphase |
| reactome | R-HSA-2980766 | Nuclear Envelope Breakdown |
| reactome | R-HSA-2993913 | Clearance of Nuclear Envelope Membranes from Chromatin |
| reactome | R-HSA-2995383 | Initiation of Nuclear Envelope Reformation |
| reactome | R-HSA-2995410 | Nuclear Envelope Reassembly |
| reactome | R-HSA-68875 | Mitotic Prophase |
| reactome | R-HSA-68882 | Mitotic Anaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD433 | Lexibulin | 2 |
| iGMDRD387 | CHIR-99021 | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD187 | BRD9876 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in VRK1
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