VRK1


Summary: This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
vaccinia related kinase 1MIM:602168Ensembl:ENSG00000100749HGNC:HGNC:12718PA3733014q32.2

GO terms in VRK1


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0004672protein kinase activity
MFIBAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIDAGO:0019901protein kinase binding
MFIPIGO:0031493nucleosomal histone binding
MFIDAGO:0035175histone kinase activity (H3-S10 specific)
MFIDAGO:0072354histone kinase activity (H3-T3 specific)
BPIDAGO:0006468protein phosphorylation
BPTASGO:0007077mitotic nuclear envelope disassembly
BPTASGO:0007084mitotic nuclear envelope reassembly
BPIBAGO:0018105peptidyl-serine phosphorylation
BPIDAGO:0043987histone H3-S10 phosphorylation
BPIDAGO:0046777protein autophosphorylation
BPIEAGO:0051301cell division
BPIDAGO:0072355histone H3-T3 phosphorylation
BPIDAGO:0090166Golgi disassembly
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005730nucleolus
CCIBAGO:0005737cytoplasm
CCIDAGO:0005795Golgi stack
CCIEAGO:0005819spindle
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol

Gene expression in normal tissue: VRK1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in VRK1


DatabasePathway IDPathway Des.
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-2555396Mitotic Metaphase and Anaphase
reactomeR-HSA-2980766Nuclear Envelope Breakdown
reactomeR-HSA-2993913Clearance of Nuclear Envelope Membranes from Chromatin
reactomeR-HSA-2995383Initiation of Nuclear Envelope Reformation
reactomeR-HSA-2995410Nuclear Envelope Reassembly
reactomeR-HSA-68875Mitotic Prophase
reactomeR-HSA-68882Mitotic Anaphase
reactomeR-HSA-68886M Phase
reactomeR-HSA-69278Cell Cycle, Mitotic

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD446LY 21832404
iGMDRD85Ursolic acid2
iGMDRD123Isoevodiamine2
iGMDRD433Lexibulin2
iGMDRD387CHIR-990212
iGMDRD345Compound 10b [PMID: 11504634]2
iGMDRD871BRD63682
iGMDRD188Piperlongumine4
iGMDRD662JQ-12
iGMDRD888Compound 443
iGMDRD398Sepantronium2
iGMDRD64Parbendazole2
iGMDRD268Cerulenin2
iGMDRD138PX 122
iGMDRD5Tyrphostin AG 14782
iGMDRD289Parthenolide2
iGMDRD434BMS-5369243
iGMDRD187BRD98761

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in VRK1

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