BRIP1
Summary: The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:605882 Ensembl IDEnsembl:ENSG00000136492 HGNC IDHGNC:HGNC:20473 PHARMGKB IDPA134906421 Map Location17q23.2 | |||||
GO terms in BRIP1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | NAS | GO:0000077 | DNA damage checkpoint |
| BP | TAS | GO:0006260 | DNA replication |
| BP | IBA | GO:0006289 | nucleotide-excision repair |
| BP | NAS | GO:0006302 | double-strand break repair |
| BP | IDA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0007284 | spermatogonial cell division |
Gene expression in normal tissue: BRIP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BRIP1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BRIP1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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