BRIP1
Summary: The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| BRCA1 interacting protein C-terminal helicase 1 | MIM:605882 | Ensembl:ENSG00000136492 | HGNC:HGNC:20473 | PA134906421 | 17q23.2 |
GO terms in BRIP1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | NAS | GO:0000077 | DNA damage checkpoint |
| BP | TAS | GO:0006260 | DNA replication |
| BP | IBA | GO:0006289 | nucleotide-excision repair |
| BP | NAS | GO:0006302 | double-strand break repair |
| BP | IDA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0007284 | spermatogonial cell division |
| BP | IEA | GO:0007286 | spermatid development |
| BP | IEA | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0009636 | response to toxic substance |
| BP | IEA | GO:0010629 | negative regulation of gene expression |
| BP | IEA | GO:0010705 | meiotic DNA double-strand break processing involved in reciprocal meiotic recombination |
| BP | IEA | GO:0032508 | DNA duplex unwinding |
| BP | IEA | GO:0051026 | chiasma assembly |
| BP | IEA | GO:0071295 | cellular response to vitamin |
| BP | IEA | GO:0071456 | cellular response to hypoxia |
| BP | IEA | GO:0072520 | seminiferous tubule development |
| BP | IEA | GO:1904385 | cellular response to angiotensin |
| BP | IBA | GO:1990918 | double-strand break repair involved in meiotic recombination |
| BP | IEA | GO:1990918 | double-strand break repair involved in meiotic recombination |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | NAS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0031965 | nuclear membrane |
| MF | NAS | GO:0003677 | DNA binding |
| MF | IEA | GO:0003682 | chromatin binding |
| MF | IBA | GO:0004003 | ATP-dependent DNA helicase activity |
| MF | NAS | GO:0004003 | ATP-dependent DNA helicase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IEA | GO:0051539 | 4 iron, 4 sulfur cluster binding |
Gene expression in normal tissue: BRIP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BRIP1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-5685938 | HDR through Single Strand Annealing (SSA) |
| reactome | R-HSA-5685942 | HDR through Homologous Recombination (HRR) |
| reactome | R-HSA-5693532 | DNA Double-Strand Break Repair |
| reactome | R-HSA-5693537 | Resolution of D-Loop Structures |
| reactome | R-HSA-5693538 | Homology Directed Repair |
| reactome | R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) |
| reactome | R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| reactome | R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates |
| reactome | R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange |
| reactome | R-HSA-5693607 | Processing of DNA double-strand break ends |
| reactome | R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange |
| reactome | R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation |
| reactome | R-HSA-69473 | G2/M DNA damage checkpoint |
| reactome | R-HSA-69481 | G2/M Checkpoints |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| pid | fanconi_pathway | Fanconi anemia pathway |
| kegg | hsa03440 | Homologous recombination - Homo sapiens (human) |
| kegg | hsa03460 | Fanconi anemia pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD782 | DC-45-A2 | 1 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 4 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD187 | BRD9876 | 5 |
| iGMDRD513 | BML-259 | 2 |
| iGMDRD138 | PX 12 | 5 |
| iGMDRD255 | SB225002 | 6 |
| iGMDRD260 | FQI-2 | 3 |
| iGMDRD64 | Parbendazole | 7 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD451 | Serdemetan | 4 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD546 | BMS-754807 | 6 |
| iGMDRD494 | Neopeltolide | 1 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD599 | Salermide | 1 |
| iGMDRD1008 | SR-II-138A | 6 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD446 | LY 2183240 | 7 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD105 | Triptolide | 8 |
| iGMDRD103 | SN-38 | 6 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD202 | Curcumin | 1 |
| iGMDRD505 | Pevonedistat | 6 |
| iGMDRD552 | AZD-1775 | 1 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD82 | Quiflapon | 1 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD286 | Nsc 632839 | 5 |
| iGMDRD414 | MST-312 | 6 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD366 | PI-103 | 1 |
| iGMDRD150 | RITA | 4 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 1 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD511 | CHEMBL399379 | 3 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD351 | GW843682X | 4 |
| iGMDRD314 | Tanespimycin | 2 |
| iGMDRD237 | ABT-751 | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BRIP1
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.