AFF3
Summary: This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| AF4/FMR2 family member 3 | MIM:601464 | Ensembl:ENSG00000144218 | HGNC:HGNC:6473 | PA30264 | 2q11.2 |
GO terms in AFF3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IMP | GO:0034612 | response to tumor necrosis factor |
| BP | IMP | GO:0035116 | embryonic hindlimb morphogenesis |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IBA | GO:0008023 | transcription elongation factor complex |
| CC | IDA | GO:0016604 | nuclear body |
| CC | IBA | GO:0032783 | ELL-EAF complex |
| MF | IBA | GO:0003690 | double-stranded DNA binding |
| MF | IDA | GO:0003690 | double-stranded DNA binding |
| MF | IBA | GO:0003700 | DNA-binding transcription factor activity |
Gene expression in normal tissue: AFF3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AFF3
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD126 | Tipifarnib | 7 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 4 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD100 | Zebularine | 1 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD202 | Curcumin | 1 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD77 | Itraconazole | 4 |
| iGMDRD187 | BRD9876 | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AFF3
CLASSFICATION
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