TANK

Summary: The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameTRAF family member associated NFKB activator
OMIM IDMIM:603893
Ensembl IDEnsembl:ENSG00000136560
HGNC IDHGNC:HGNC:11562
PHARMGKB IDPA36330
Map Location2q24.2

Gene Categories:

PROTEASE

GO terms in TANK


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IMP GO:0004843 thiol-dependent ubiquitin-specific protease activity
MF IPI GO:0005515 protein binding
MF IPI GO:0031625 ubiquitin protein ligase binding
MF IMP GO:0035800 deubiquitinase activator activity
MF IEA GO:0046872 metal ion binding
BP IEA GO:0006508 proteolysis
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Gene expression in normal tissue: TANK

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 143undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 3LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 18BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 5OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 4UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 10

Gene-drug pathway distribution

undefined46Apoptosis regulation3PI3K/MTOR signaling2Mitosis1IGFR signaling1Protein stability and degradation1Th17 cell differentiation1Longevity regulating pathway1p53 pathway1RTK signaling1

Pathways in TANK


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Database
Pathway ID
Pathway Des.
kegg hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
kegg hsa04622 RIG-I-like receptor signaling pathway - Homo sapiens (human)
netpath Pathway_TNFalpha TNFalpha
wikipathways WP231 TNF alpha Signaling Pathway
wikipathways WP2637 Structural Pathway of Interleukin 1 (IL-1)
wikipathways WP3865 RIG-I-like Receptor Signaling
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD158 NSC141540 3
iGMDRD121 GMX1778 2
iGMDRD137 Indisulam 3
iGMDRD213 SMR000068650 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TANK

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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