TANK
Summary: The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:603893 Ensembl IDEnsembl:ENSG00000136560 HGNC IDHGNC:HGNC:11562 PHARMGKB IDPA36330 Map Location2q24.2 |
Gene Categories:
PROTEASEGO terms in TANK
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IMP | GO:0004843 | thiol-dependent ubiquitin-specific protease activity |
MF | IPI | GO:0005515 | protein binding |
MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
MF | IMP | GO:0035800 | deubiquitinase activator activity |
MF | IEA | GO:0046872 | metal ion binding |
BP | IEA | GO:0006508 | proteolysis |
Gene expression in normal tissue: TANK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TANK
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Database | Pathway ID | Pathway Des. |
---|---|---|
kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
kegg | hsa04622 | RIG-I-like receptor signaling pathway - Homo sapiens (human) |
netpath | Pathway_TNFalpha | TNFalpha |
wikipathways | WP231 | TNF alpha Signaling Pathway |
wikipathways | WP2637 | Structural Pathway of Interleukin 1 (IL-1) |
wikipathways | WP3865 | RIG-I-like Receptor Signaling |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in TANK
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |