TANK
Summary: The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TRAF family member associated NFKB activator | MIM:603893 | Ensembl:ENSG00000136560 | HGNC:HGNC:11562 | PA36330 | 2q24.2 |
Gene Categories:
PROTEASEGO terms in TANK
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IMP | GO:0004843 | thiol-dependent ubiquitin-specific protease activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IMP | GO:0035800 | deubiquitinase activator activity |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | IEA | GO:0006508 | proteolysis |
| BP | IMP | GO:0006974 | cellular response to DNA damage stimulus |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IBA | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| BP | IEA | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| BP | IEA | GO:0016032 | viral process |
| BP | TAS | GO:0035666 | TRIF-dependent toll-like receptor signaling pathway |
| BP | IMP | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IMP | GO:0071347 | cellular response to interleukin-1 |
| BP | IMP | GO:0071356 | cellular response to tumor necrosis factor |
| BP | IMP | GO:0071479 | cellular response to ionizing radiation |
| BP | IMP | GO:1903003 | positive regulation of protein deubiquitination |
| BP | IMP | GO:2000158 | positive regulation of ubiquitin-specific protease activity |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0032991 | protein-containing complex |
Gene expression in normal tissue: TANK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TANK
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04622 | RIG-I-like receptor signaling pathway - Homo sapiens (human) |
| netpath | Pathway_TNFalpha | TNFalpha |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP2637 | Structural Pathway of Interleukin 1 (IL-1) |
| wikipathways | WP3865 | RIG-I-like Receptor Signaling |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| reactome | R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 |
| reactome | R-HSA-933541 | TRAF6 mediated IRF7 activation |
| reactome | R-HSA-936964 | Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| biocarta | stresspathway | tnf/stress related signaling |
| biocarta | tnfr2pathway | tnfr2 signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD532 | Olaparib | 4 |
| iGMDRD560 | MK-2206 | 1 |
| iGMDRD945 | ML214 | 5 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 2 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD74 | Idarubicin | 5 |
| iGMDRD730 | Kahalalide F | 2 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD425 | ERASTIN | 2 |
| iGMDRD889 | Compound 7d-cis | 5 |
| iGMDRD126 | Tipifarnib | 5 |
| iGMDRD781 | Sirolimus | 8 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD639 | YK 4-279 | 2 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD220 | fumonisin B1 | 1 |
| iGMDRD481 | Dactolisib | 2 |
| iGMDRD434 | BMS-536924 | 5 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD882 | CIL41 | 2 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD148 | Pifithrin-mu | 1 |
| iGMDRD607 | Ubistatin B | 2 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD307 | Manumycin A | 2 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD701 | NVP-AUY922 | 1 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD424 | Tamatinib | 4 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 1 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD270 | Ciclosporin | 2 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD885 | Compound 110 | 2 |
| iGMDRD441 | TW 37 | 2 |
| iGMDRD318 | PAC-1 | 4 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD577 | BIX01294 | 10 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD444 | Tivantinib | 2 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD690 | PRIMA-1MET | 4 |
| iGMDRD772 | BRD4770 | 6 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD297 | Austocystin D | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TANK
CLASSFICATION
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