RPL22
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-p36.2. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
ribosomal protein L22 | MIM:180474 | Ensembl:ENSG00000116251 | HGNC:HGNC:10315 | PA34688 | 1p36.31 |
GO terms in RPL22
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | IDA | GO:0005634 | nucleus |
CC | IDA | GO:0005737 | cytoplasm |
CC | TAS | GO:0005829 | cytosol |
CC | HDA | GO:0005925 | focal adhesion |
CC | HDA | GO:0022625 | cytosolic large ribosomal subunit |
CC | IBA | GO:0022625 | cytosolic large ribosomal subunit |
CC | HDA | GO:0070062 | extracellular exosome |
CC | IDA | GO:1990904 | ribonucleoprotein complex |
BP | TAS | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
BP | IBA | GO:0002181 | cytoplasmic translation |
BP | NAS | GO:0006412 | translation |
BP | TAS | GO:0006413 | translational initiation |
BP | TAS | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane |
BP | IEA | GO:0046632 | alpha-beta T cell differentiation |
MF | HDA | GO:0003723 | RNA binding |
MF | IBA | GO:0003735 | structural constituent of ribosome |
MF | NAS | GO:0003735 | structural constituent of ribosome |
MF | IPI | GO:0005515 | protein binding |
MF | IEA | GO:0008201 | heparin binding |
Gene expression in normal tissue: RPL22
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RPL22
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-1266738 | Developmental Biology |
reactome | R-HSA-1430728 | Metabolism |
reactome | R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression |
reactome | R-HSA-156842 | Eukaryotic Translation Elongation |
reactome | R-HSA-156902 | Peptide chain elongation |
reactome | R-HSA-1643685 | Disease |
reactome | R-HSA-168254 | Influenza Infection |
reactome | R-HSA-168255 | Influenza Life Cycle |
reactome | R-HSA-168273 | Influenza Viral RNA Transcription and Replication |
reactome | R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane |
reactome | R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane |
reactome | R-HSA-192823 | Viral mRNA Translation |
reactome | R-HSA-2408522 | Selenoamino acid metabolism |
reactome | R-HSA-2408557 | Selenocysteine synthesis |
reactome | R-HSA-376176 | Signaling by ROBO receptors |
reactome | R-HSA-392499 | Metabolism of proteins |
reactome | R-HSA-392499 | Metabolism of proteins |
reactome | R-HSA-422475 | Axon guidance |
reactome | R-HSA-5663205 | Infectious disease |
reactome | R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol |
reactome | R-HSA-71291 | Metabolism of amino acids and derivatives |
reactome | R-HSA-72312 | rRNA processing |
reactome | R-HSA-72613 | Eukaryotic Translation Initiation |
reactome | R-HSA-72689 | Formation of a pool of free 40S subunits |
reactome | R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit |
reactome | R-HSA-72737 | Cap-dependent Translation Initiation |
reactome | R-HSA-72764 | Eukaryotic Translation Termination |
reactome | R-HSA-72766 | Translation |
reactome | R-HSA-72766 | Translation |
reactome | R-HSA-8868773 | rRNA processing in the nucleus and cytosol |
reactome | R-HSA-8953854 | Metabolism of RNA |
reactome | R-HSA-9010553 | Regulation of expression of SLITs and ROBOs |
reactome | R-HSA-927802 | Nonsense-Mediated Decay (NMD) |
reactome | R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) |
reactome | R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
kegg | hsa03010 | Ribosome - Homo sapiens (human) |
wikipathways | WP477 | Cytoplasmic Ribosomal Proteins |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD778 | SCHEMBL13586708 | 1 |
iGMDRD280 | CYTOCHALASIN B | 5 |
iGMDRD348 | BMS-345541 | 1 |
iGMDRD634 | SCHEMBL2608041 | 5 |
iGMDRD446 | LY 2183240 | 1 |
iGMDRD163 | all trans Retinoic Acid | 2 |
iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
iGMDRD144 | NSC95397 | 2 |
iGMDRD427 | ABT737 | 7 |
iGMDRD494 | Neopeltolide | 2 |
iGMDRD126 | Tipifarnib | 3 |
iGMDRD1008 | SR-II-138A | 2 |
iGMDRD889 | Compound 7d-cis | 5 |
iGMDRD443 | Linifanib | 1 |
iGMDRD356 | PNU-74654 | 1 |
iGMDRD332 | A-770041 | 1 |
iGMDRD730 | Kahalalide F | 2 |
iGMDRD188 | Piperlongumine | 1 |
iGMDRD562 | Navitoclax | 2 |
iGMDRD577 | BIX01294 | 4 |
iGMDRD506 | Fedratinib | 1 |
iGMDRD294 | Batimastat | 2 |
iGMDRD870 | BRD63610 | 3 |
iGMDRD318 | PAC-1 | 3 |
iGMDRD513 | BML-259 | 2 |
iGMDRD507 | GSK690693 | 1 |
iGMDRD255 | SB225002 | 1 |
iGMDRD700 | AUY922 | 1 |
iGMDRD511 | CHEMBL399379 | 3 |
iGMDRD314 | Tanespimycin | 3 |
iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
iGMDRD150 | RITA | 7 |
iGMDRD701 | NVP-AUY922 | 2 |
iGMDRD405 | PIK-75 | 2 |
iGMDRD607 | Ubistatin B | 2 |
iGMDRD505 | Pevonedistat | 8 |
iGMDRD400 | A-443654 | 1 |
iGMDRD871 | BRD6368 | 1 |
iGMDRD269 | Purmorphamine | 2 |
iGMDRD662 | JQ-1 | 2 |
iGMDRD329 | Merck60 | 1 |
iGMDRD241 | Sunitinib | 1 |
iGMDRD434 | BMS-536924 | 1 |
iGMDRD455 | Idelalisib | 1 |
iGMDRD77 | Itraconazole | 3 |
iGMDRD311 | Dacinostat | 1 |
iGMDRD459 | RO-3306 | 1 |
iGMDRD137 | Indisulam | 5 |
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in RPL22