RPL22


Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-p36.2. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ribosomal protein L22MIM:180474Ensembl:ENSG00000116251HGNC:HGNC:10315PA346881p36.31

GO terms in RPL22


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005634nucleus
CCIDAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCHDAGO:0005925focal adhesion
CCHDAGO:0022625cytosolic large ribosomal subunit
CCIBAGO:0022625cytosolic large ribosomal subunit
CCHDAGO:0070062extracellular exosome
CCIDAGO:1990904ribonucleoprotein complex
BPTASGO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
BPIBAGO:0002181cytoplasmic translation
BPNASGO:0006412translation
BPTASGO:0006413translational initiation
BPTASGO:0006614SRP-dependent cotranslational protein targeting to membrane
BPIEAGO:0046632alpha-beta T cell differentiation
MFHDAGO:0003723RNA binding
MFIBAGO:0003735structural constituent of ribosome
MFNASGO:0003735structural constituent of ribosome
MFIPIGO:0005515protein binding
MFIEAGO:0008201heparin binding

Gene expression in normal tissue: RPL22

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RPL22


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-156827L13a-mediated translational silencing of Ceruloplasmin expression
reactomeR-HSA-156842Eukaryotic Translation Elongation
reactomeR-HSA-156902Peptide chain elongation
reactomeR-HSA-1643685Disease
reactomeR-HSA-168254Influenza Infection
reactomeR-HSA-168255Influenza Life Cycle
reactomeR-HSA-168273Influenza Viral RNA Transcription and Replication
reactomeR-HSA-1799339SRP-dependent cotranslational protein targeting to membrane
reactomeR-HSA-1799339SRP-dependent cotranslational protein targeting to membrane
reactomeR-HSA-192823Viral mRNA Translation
reactomeR-HSA-2408522Selenoamino acid metabolism
reactomeR-HSA-2408557Selenocysteine synthesis
reactomeR-HSA-376176Signaling by ROBO receptors
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-6791226Major pathway of rRNA processing in the nucleolus and cytosol
reactomeR-HSA-71291Metabolism of amino acids and derivatives
reactomeR-HSA-72312rRNA processing
reactomeR-HSA-72613Eukaryotic Translation Initiation
reactomeR-HSA-72689Formation of a pool of free 40S subunits
reactomeR-HSA-72706GTP hydrolysis and joining of the 60S ribosomal subunit
reactomeR-HSA-72737Cap-dependent Translation Initiation
reactomeR-HSA-72764Eukaryotic Translation Termination
reactomeR-HSA-72766Translation
reactomeR-HSA-72766Translation
reactomeR-HSA-8868773rRNA processing in the nucleus and cytosol
reactomeR-HSA-8953854Metabolism of RNA
reactomeR-HSA-9010553Regulation of expression of SLITs and ROBOs
reactomeR-HSA-927802Nonsense-Mediated Decay (NMD)
reactomeR-HSA-975956Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
reactomeR-HSA-975957Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
kegghsa03010Ribosome - Homo sapiens (human)
wikipathwaysWP477Cytoplasmic Ribosomal Proteins

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD778SCHEMBL135867081
iGMDRD280CYTOCHALASIN B5
iGMDRD348BMS-3455411
iGMDRD634SCHEMBL26080415
iGMDRD446LY 21832401
iGMDRD163all trans Retinoic Acid2
iGMDRD316N9-Isopropyl-olomoucine2
iGMDRD144NSC953972
iGMDRD427ABT7377
iGMDRD494Neopeltolide2
iGMDRD126Tipifarnib3
iGMDRD1008SR-II-138A2
iGMDRD889Compound 7d-cis5
iGMDRD443Linifanib1
iGMDRD356PNU-746541
iGMDRD332A-7700411
iGMDRD730Kahalalide F2
iGMDRD188Piperlongumine1
iGMDRD562Navitoclax2
iGMDRD577BIX012944
iGMDRD506Fedratinib1
iGMDRD294Batimastat2
iGMDRD870BRD636103
iGMDRD318PAC-13
iGMDRD513BML-2592
iGMDRD507GSK6906931
iGMDRD255SB2250021
iGMDRD700AUY9221
iGMDRD511CHEMBL3993793
iGMDRD314Tanespimycin3
iGMDRD345Compound 10b [PMID: 11504634]3
iGMDRD150RITA7
iGMDRD701NVP-AUY9222
iGMDRD405PIK-752
iGMDRD607Ubistatin B2
iGMDRD505Pevonedistat8
iGMDRD400A-4436541
iGMDRD871BRD63681
iGMDRD269Purmorphamine2
iGMDRD662JQ-12
iGMDRD329Merck601
iGMDRD241Sunitinib1
iGMDRD434BMS-5369241
iGMDRD455Idelalisib1
iGMDRD77Itraconazole3
iGMDRD311Dacinostat1
iGMDRD459RO-33061
iGMDRD137Indisulam5

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RPL22

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