C1D
Summary: The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10.[provided by RefSeq, Jun 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| C1D nuclear receptor corepressor | MIM:606997 | Ensembl:ENSG00000197223 | HGNC:HGNC:29911 | PA164717007 | 2p14 |
GO terms in C1D
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0000176 | nuclear exosome (RNase complex) |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0017053 | transcriptional repressor complex |
| BP | IMP | GO:0000460 | maturation of 5.8S rRNA |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | TAS | GO:0006364 | rRNA processing |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IEA | GO:0045892 | negative regulation of transcription, DNA-templated |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IEA | GO:0003714 | transcription corepressor activity |
| MF | IDA | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0016922 | nuclear receptor binding |
Gene expression in normal tissue: C1D
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in C1D
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa03018 | RNA degradation - Homo sapiens (human) |
| reactome | R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol |
| reactome | R-HSA-72312 | rRNA processing |
| reactome | R-HSA-8868773 | rRNA processing in the nucleus and cytosol |
| reactome | R-HSA-8953854 | Metabolism of RNA |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD126 | Tipifarnib | 5 |
| iGMDRD433 | Lexibulin | 5 |
| iGMDRD151 | CHM-1 | 6 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD420 | Leucascandrolide A | 5 |
| iGMDRD670 | ML 210 | 6 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD484 | Pluripotin | 6 |
| iGMDRD639 | YK 4-279 | 1 |
| iGMDRD260 | FQI-2 | 5 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD64 | Parbendazole | 7 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD248 | BRD4354 | 3 |
| iGMDRD150 | RITA | 6 |
| iGMDRD523 | Cyanoquinoline, 11 | 2 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD583 | LDN 193189 | 2 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD883 | CIL55A | 2 |
| iGMDRD945 | ML214 | 1 |
| iGMDRD154 | NSC23766 | 5 |
| iGMDRD103 | SN-38 | 5 |
| iGMDRD202 | Curcumin | 5 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD158 | NSC141540 | 6 |
| iGMDRD137 | Indisulam | 10 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD705 | Nakiterpiosin | 9 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD105 | Triptolide | 5 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD366 | PI-103 | 3 |
| iGMDRD263 | AACOCF3 | 2 |
| iGMDRD552 | AZD-1775 | 5 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD1008 | SR-II-138A | 1 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD718 | Pyrvinium pamoate | 1 |
| iGMDRD193 | Fqi1 | 6 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD138 | PX 12 | 6 |
| iGMDRD255 | SB225002 | 6 |
| iGMDRD870 | BRD63610 | 4 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD486 | Tosedostat | 3 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD116 | CD437 | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 5 |
| iGMDRD351 | GW843682X | 4 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD177 | Teniposide | 9 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD435 | BI-2536 | 5 |
| iGMDRD271 | Brefeldin A | 2 |
| iGMDRD192 | CIL56 | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD267 | Oligomycin A | 7 |
| iGMDRD414 | MST-312 | 5 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD505 | Pevonedistat | 6 |
| iGMDRD246 | NPC26 | 4 |
| iGMDRD42 | Vorinostat | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in C1D
CLASSFICATION
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