PKMYT1
Summary: This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein kinase, membrane associated tyrosine/threonine 1 | MIM:602474 | Ensembl:ENSG00000127564 | HGNC:HGNC:29650 | PA385 | 16p13.3 |
GO terms in PKMYT1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0000139 | Golgi membrane |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005730 | nucleolus |
| CC | TAS | GO:0005783 | endoplasmic reticulum |
| CC | IEA | GO:0005789 | endoplasmic reticulum membrane |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | TAS | GO:0005829 | cytosol |
| CC | HDA | GO:0016020 | membrane |
| BP | TAS | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | TAS | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | TAS | GO:0000278 | mitotic cell cycle |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007088 | regulation of mitotic nuclear division |
| BP | IDA | GO:0010923 | negative regulation of phosphatase activity |
| BP | IBA | GO:0051321 | meiotic cell cycle |
| MF | IBA | GO:0004672 | protein kinase activity |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IEA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0016301 | kinase activity |
| MF | TAS | GO:0016301 | kinase activity |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: PKMYT1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PKMYT1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-156711 | Polo-like kinase mediated events |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition |
| reactome | R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69478 | G2/M DNA replication checkpoint |
| reactome | R-HSA-69481 | G2/M Checkpoints |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| kegg | hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| kegg | hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
| wikipathways | WP179 | Cell Cycle |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD270 | Ciclosporin | 3 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD42 | Vorinostat | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD780 | PP-30 | 6 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD871 | BRD6368 | 9 |
| iGMDRD872 | BRD7137 | 9 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD511 | CHEMBL399379 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD219 | Bax channel blocker | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PKMYT1
CLASSFICATION
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