PKMYT1


Summary: This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
protein kinase, membrane associated tyrosine/threonine 1MIM:602474Ensembl:ENSG00000127564HGNC:HGNC:29650PA38516p13.3

GO terms in PKMYT1


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0000139Golgi membrane
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005730nucleolus
CCTASGO:0005783endoplasmic reticulum
CCIEAGO:0005789endoplasmic reticulum membrane
CCIDAGO:0005794Golgi apparatus
CCTASGO:0005829cytosol
CCHDAGO:0016020membrane
BPTASGO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity
BPTASGO:0000086G2/M transition of mitotic cell cycle
BPTASGO:0000278mitotic cell cycle
BPIEAGO:0006468protein phosphorylation
BPTASGO:0007088regulation of mitotic nuclear division
BPIDAGO:0010923negative regulation of phosphatase activity
BPIBAGO:0051321meiotic cell cycle
MFIBAGO:0004672protein kinase activity
MFTASGO:0004672protein kinase activity
MFIEAGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIDAGO:0016301kinase activity
MFTASGO:0016301kinase activity
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: PKMYT1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PKMYT1


DatabasePathway IDPathway Des.
reactomeR-HSA-156711Polo-like kinase mediated events
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-453274Mitotic G2-G2/M phases
reactomeR-HSA-453274Mitotic G2-G2/M phases
reactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transition
reactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transition
reactomeR-HSA-69275G2/M Transition
reactomeR-HSA-69275G2/M Transition
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69478G2/M DNA replication checkpoint
reactomeR-HSA-69481G2/M Checkpoints
reactomeR-HSA-69620Cell Cycle Checkpoints
kegghsa04110Cell cycle - Homo sapiens (human)
kegghsa04114Oocyte meiosis - Homo sapiens (human)
kegghsa04914Progesterone-mediated oocyte maturation - Homo sapiens (human)
wikipathwaysWP179Cell Cycle

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD318PAC-13
iGMDRD77Itraconazole3
iGMDRD870BRD636103
iGMDRD103SN-383
iGMDRD270Ciclosporin3
iGMDRD356PNU-746541
iGMDRD42Vorinostat3
iGMDRD577BIX012943
iGMDRD506Fedratinib3
iGMDRD780PP-306
iGMDRD562Navitoclax3
iGMDRD871BRD63689
iGMDRD872BRD71379
iGMDRD483SCH-5290743
iGMDRD116CD4373
iGMDRD345Compound 10b [PMID: 11504634]3
iGMDRD144NSC953973
iGMDRD889Compound 7d-cis3
iGMDRD512nutlin 33
iGMDRD126Tipifarnib3
iGMDRD511CHEMBL3993793
iGMDRD280CYTOCHALASIN B3
iGMDRD314Tanespimycin3
iGMDRD219Bax channel blocker3
iGMDRD61Kinetin riboside3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PKMYT1

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