KALRN
Summary: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. [provided by RefSeq, Apr 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| kalirin RhoGEF kinase | MIM:604605 | Ensembl:ENSG00000160145 | HGNC:HGNC:4814 | PA29189 | 3q21.1-q21.2 |
GO terms in KALRN
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0004674 | protein serine/threonine kinase activity |
| MF | EXP | GO:0005085 | guanyl-nucleotide exchange factor activity |
| MF | TAS | GO:0005085 | guanyl-nucleotide exchange factor activity |
| MF | TAS | GO:0005089 | Rho guanyl-nucleotide exchange factor activity |
| MF | TAS | GO:0005096 | GTPase activator activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0030676 | Rac guanyl-nucleotide exchange factor activity |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0014069 | postsynaptic density |
| CC | TAS | GO:0015629 | actin cytoskeleton |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IEA | GO:0001662 | behavioral fear response |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IEA | GO:0007266 | Rho protein signal transduction |
| BP | ISS | GO:0007399 | nervous system development |
| BP | IEA | GO:0007528 | neuromuscular junction development |
| BP | IEA | GO:0007595 | lactation |
| BP | IEA | GO:0007613 | memory |
| BP | IEA | GO:0008344 | adult locomotory behavior |
| BP | IEA | GO:0009612 | response to mechanical stimulus |
| BP | IEA | GO:0014909 | smooth muscle cell migration |
| BP | TAS | GO:0016192 | vesicle-mediated transport |
| BP | IEA | GO:0035023 | regulation of Rho protein signal transduction |
| BP | IEA | GO:0035176 | social behavior |
| BP | ISS | GO:0035556 | intracellular signal transduction |
| BP | IEA | GO:0042711 | maternal behavior |
| BP | TAS | GO:0043065 | positive regulation of apoptotic process |
| BP | IEA | GO:0043547 | positive regulation of GTPase activity |
| BP | IEA | GO:0046959 | habituation |
| BP | TAS | GO:0048013 | ephrin receptor signaling pathway |
| BP | IEA | GO:0048148 | behavioral response to cocaine |
| BP | IEA | GO:0048168 | regulation of neuronal synaptic plasticity |
| BP | IEA | GO:0048659 | smooth muscle cell proliferation |
| BP | TAS | GO:0051056 | regulation of small GTPase mediated signal transduction |
| BP | IEA | GO:0051966 | regulation of synaptic transmission, glutamatergic |
| BP | IEA | GO:0060125 | negative regulation of growth hormone secretion |
| BP | IEA | GO:0060137 | maternal process involved in parturition |
| BP | IEA | GO:0061003 | positive regulation of dendritic spine morphogenesis |
| BP | IEA | GO:0061368 | behavioral response to formalin induced pain |
| BP | IEA | GO:1900273 | positive regulation of long-term synaptic potentiation |
| BP | IEA | GO:1903076 | regulation of protein localization to plasma membrane |
Gene expression in normal tissue: KALRN
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KALRN
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | arf6downstreampathway | Arf6 downstream pathway |
| pid | ephbfwdpathway | EPHB forward signaling |
| pid | rac1_reg_pathway | Regulation of RAC1 activity |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-193648 | NRAGE signals death through JNK |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194840 | Rho GTPase cycle |
| reactome | R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-416482 | G alpha (12/13) signalling events |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5687128 | MAPK6/MAPK4 signaling |
| reactome | R-HSA-73887 | Death Receptor Signalling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD260 | FQI-2 | 3 |
| iGMDRD247 | Blebbistatin | 2 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 4 |
| iGMDRD224 | Necrostatin-1 | 4 |
| iGMDRD888 | Compound 44 | 5 |
| iGMDRD188 | Piperlongumine | 6 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD23 | Gossypol | 5 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD64 | Parbendazole | 4 |
| iGMDRD889 | Compound 7d-cis | 5 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD151 | CHM-1 | 5 |
| iGMDRD433 | Lexibulin | 5 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD466 | Chaetocin | 5 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD103 | SN-38 | 4 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD213 | SMR000068650 | 3 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD289 | Parthenolide | 5 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD329 | Merck60 | 6 |
| iGMDRD366 | PI-103 | 4 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD286 | Nsc 632839 | 6 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD330 | BRD4132 | 2 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD237 | ABT-751 | 7 |
| iGMDRD219 | Bax channel blocker | 2 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD123 | Isoevodiamine | 6 |
| iGMDRD255 | SB225002 | 14 |
| iGMDRD802 | 4-methylfasudil | 4 |
| iGMDRD138 | PX 12 | 6 |
| iGMDRD318 | PAC-1 | 6 |
| iGMDRD441 | TW 37 | 3 |
| iGMDRD782 | DC-45-A2 | 4 |
| iGMDRD577 | BIX01294 | 5 |
| iGMDRD268 | Cerulenin | 5 |
| iGMDRD690 | PRIMA-1MET | 8 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD201 | SKI II | 5 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD380 | Pifithrin-alpha | 2 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD280 | CYTOCHALASIN B | 6 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD872 | BRD7137 | 4 |
| iGMDRD42 | Vorinostat | 5 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD300 | Tozasertib | 6 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD607 | Ubistatin B | 2 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD148 | Pifithrin-mu | 2 |
| iGMDRD307 | Manumycin A | 7 |
| iGMDRD486 | Tosedostat | 2 |
| iGMDRD701 | NVP-AUY922 | 1 |
| iGMDRD116 | CD437 | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD177 | Teniposide | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KALRN
CLASSFICATION
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