KALRN


Summary: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. [provided by RefSeq, Apr 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
kalirin RhoGEF kinaseMIM:604605Ensembl:ENSG00000160145HGNC:HGNC:4814PA291893q21.1-q21.2

GO terms in KALRN


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0004674protein serine/threonine kinase activity
MFEXPGO:0005085guanyl-nucleotide exchange factor activity
MFTASGO:0005085guanyl-nucleotide exchange factor activity
MFTASGO:0005089Rho guanyl-nucleotide exchange factor activity
MFTASGO:0005096GTPase activator activity
MFIEAGO:0005524ATP binding
MFIEAGO:0030676Rac guanyl-nucleotide exchange factor activity
MFIEAGO:0046872metal ion binding
CCIDAGO:0005654nucleoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIEAGO:0014069postsynaptic density
CCTASGO:0015629actin cytoskeleton
CCHDAGO:0070062extracellular exosome
BPIEAGO:0001662behavioral fear response
BPIEAGO:0006468protein phosphorylation
BPTASGO:0007165signal transduction
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPIEAGO:0007266Rho protein signal transduction
BPISSGO:0007399nervous system development
BPIEAGO:0007528neuromuscular junction development
BPIEAGO:0007595lactation
BPIEAGO:0007613memory
BPIEAGO:0008344adult locomotory behavior
BPIEAGO:0009612response to mechanical stimulus
BPIEAGO:0014909smooth muscle cell migration
BPTASGO:0016192vesicle-mediated transport
BPIEAGO:0035023regulation of Rho protein signal transduction
BPIEAGO:0035176social behavior
BPISSGO:0035556intracellular signal transduction
BPIEAGO:0042711maternal behavior
BPTASGO:0043065positive regulation of apoptotic process
BPIEAGO:0043547positive regulation of GTPase activity
BPIEAGO:0046959habituation
BPTASGO:0048013ephrin receptor signaling pathway
BPIEAGO:0048148behavioral response to cocaine
BPIEAGO:0048168regulation of neuronal synaptic plasticity
BPIEAGO:0048659smooth muscle cell proliferation
BPTASGO:0051056regulation of small GTPase mediated signal transduction
BPIEAGO:0051966regulation of synaptic transmission, glutamatergic
BPIEAGO:0060125negative regulation of growth hormone secretion
BPIEAGO:0060137maternal process involved in parturition
BPIEAGO:0061003positive regulation of dendritic spine morphogenesis
BPIEAGO:0061368behavioral response to formalin induced pain
BPIEAGO:1900273positive regulation of long-term synaptic potentiation
BPIEAGO:1903076regulation of protein localization to plasma membrane

Gene expression in normal tissue: KALRN

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KALRN


DatabasePathway IDPathway Des.
pidarf6downstreampathwayArf6 downstream pathway
pidephbfwdpathwayEPHB forward signaling
pidrac1_reg_pathwayRegulation of RAC1 activity
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-193648NRAGE signals death through JNK
reactomeR-HSA-193704p75 NTR receptor-mediated signalling
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-194840Rho GTPase cycle
reactomeR-HSA-204998Cell death signalling via NRAGE, NRIF and NADE
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-3928662EPHB-mediated forward signaling
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-416482G alpha (12/13) signalling events
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5687128MAPK6/MAPK4 signaling
reactomeR-HSA-73887Death Receptor Signalling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD260FQI-23
iGMDRD247Blebbistatin2
iGMDRD8012,4-dideoxy-DC-45-A24
iGMDRD224Necrostatin-14
iGMDRD888Compound 445
iGMDRD188Piperlongumine6
iGMDRD74Idarubicin3
iGMDRD23Gossypol5
iGMDRD524ISX-93
iGMDRD64Parbendazole4
iGMDRD889Compound 7d-cis5
iGMDRD420Leucascandrolide A3
iGMDRD151CHM-15
iGMDRD433Lexibulin5
iGMDRD781Sirolimus2
iGMDRD466Chaetocin5
iGMDRD679Bistramide A3
iGMDRD103SN-384
iGMDRD202Curcumin3
iGMDRD158NSC1415402
iGMDRD137Indisulam3
iGMDRD77Itraconazole3
iGMDRD213SMR0000686503
iGMDRD705Nakiterpiosin3
iGMDRD289Parthenolide5
iGMDRD105Triptolide2
iGMDRD329Merck606
iGMDRD366PI-1034
iGMDRD367Ro 28-16752
iGMDRD871BRD63682
iGMDRD286Nsc 6328396
iGMDRD147Prima-11
iGMDRD330BRD41322
iGMDRD79Gemcitabine3
iGMDRD532Olaparib3
iGMDRD237ABT-7517
iGMDRD219Bax channel blocker2
iGMDRD945ML2143
iGMDRD154NSC237663
iGMDRD123Isoevodiamine6
iGMDRD255SB22500214
iGMDRD8024-methylfasudil4
iGMDRD138PX 126
iGMDRD318PAC-16
iGMDRD441TW 373
iGMDRD782DC-45-A24
iGMDRD577BIX012945
iGMDRD268Cerulenin5
iGMDRD690PRIMA-1MET8
iGMDRD60Quinoclamine2
iGMDRD772BRD47703
iGMDRD494Neopeltolide2
iGMDRD144NSC953973
iGMDRD193Fqi13
iGMDRD446LY 21832403
iGMDRD201SKI II5
iGMDRD375GW-4058332
iGMDRD634SCHEMBL26080412
iGMDRD380Pifithrin-alpha2
iGMDRD297Austocystin D3
iGMDRD280CYTOCHALASIN B6
iGMDRD267Oligomycin A3
iGMDRD434BMS-5369242
iGMDRD414MST-3123
iGMDRD872BRD71374
iGMDRD42Vorinostat5
iGMDRD353PD03259011
iGMDRD300Tozasertib6
iGMDRD246NPC263
iGMDRD607Ubistatin B2
iGMDRD512nutlin 33
iGMDRD148Pifithrin-mu2
iGMDRD307Manumycin A7
iGMDRD486Tosedostat2
iGMDRD701NVP-AUY9221
iGMDRD116CD4372
iGMDRD345Compound 10b [PMID: 11504634]2
iGMDRD351GW843682X2
iGMDRD132(-)-gallocatechin-3-O-gallate3
iGMDRD901ELCPK3
iGMDRD177Teniposide4

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KALRN

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