PLCG2
Summary: The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| phospholipase C gamma 2 | MIM:600220 | Ensembl:ENSG00000197943 | HGNC:HGNC:9066 | PA33393 | 16q23.3 |
GO terms in PLCG2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0002092 | positive regulation of receptor internalization |
| BP | TAS | GO:0002223 | stimulatory C-type lectin receptor signaling pathway |
| BP | IEA | GO:0002316 | follicular B cell differentiation |
| BP | IDA | GO:0006661 | phosphatidylinositol biosynthetic process |
| BP | IEA | GO:0009395 | phospholipid catabolic process |
| BP | IEA | GO:0010468 | regulation of gene expression |
| BP | TAS | GO:0016055 | Wnt signaling pathway |
| BP | NAS | GO:0019722 | calcium-mediated signaling |
| BP | TAS | GO:0030168 | platelet activation |
| BP | ISS | GO:0030183 | B cell differentiation |
| BP | IEA | GO:0032237 | activation of store-operated calcium channel activity |
| BP | IEA | GO:0032481 | positive regulation of type I interferon production |
| BP | IEA | GO:0032496 | response to lipopolysaccharide |
| BP | IEA | GO:0032959 | inositol trisphosphate biosynthetic process |
| BP | TAS | GO:0038095 | Fc-epsilon receptor signaling pathway |
| BP | TAS | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis |
| BP | IEA | GO:0043069 | negative regulation of programmed cell death |
| BP | TAS | GO:0043647 | inositol phosphate metabolic process |
| BP | ISS | GO:0050852 | T cell receptor signaling pathway |
| BP | ISS | GO:0050853 | B cell receptor signaling pathway |
| BP | IDA | GO:0051209 | release of sequestered calcium ion into cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
| MF | IPI | GO:0001784 | phosphotyrosine residue binding |
| MF | IDA | GO:0004435 | phosphatidylinositol phospholipase C activity |
| MF | TAS | GO:0004435 | phosphatidylinositol phospholipase C activity |
| MF | TAS | GO:0004629 | phospholipase C activity |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: PLCG2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PLCG2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | ar_nongenomic_pathway | Nongenotropic Androgen signaling |
| pid | bcr_5pathway | BCR signaling pathway |
| pid | epopathway | EPO signaling pathway |
| pid | pi3kcipathway | Class I PI3K signaling events |
| pharmgkb | PA152530845 | Proton Pump Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA154444041 | Platelet Aggregation Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA2032 | VEGF Signaling Pathway |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_CRH | CRH |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_IL4 | IL4 |
| netpath | Pathway_Leptin | Leptin |
| netpath | Pathway_TCR | TCR |
| kegg | hsa00562 | Inositol phosphate metabolism - Homo sapiens (human) |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| kegg | hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04664 | Fc epsilon RI signaling pathway - Homo sapiens (human) |
| kegg | hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| kegg | hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| kegg | hsa05110 | Vibrio cholerae infection - Homo sapiens (human) |
| kegg | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05214 | Glioma - Homo sapiens (human) |
| kegg | hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| humancyc | LIPASYN-PWY | phospholipases |
| humancyc | PWY-6351 | D-myo-inositol (1,4,5)-trisphosphate biosynthesis |
| humancyc | PWY-6367 | D-myo-inositol-5-phosphate metabolism |
| humancyc | PWY-6371 | superpathway of inositol phosphate compounds |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| wikipathways | WP3937 | Microglia Pathogen Phagocytosis Pathway |
| wikipathways | WP3958 | GPR40 Pathway |
| wikipathways | WP4223 | Ras Signaling |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114604 | GPVI-mediated activation cascade |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1483249 | Inositol phosphate metabolism |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029485 | Role of phospholipids in phagocytosis |
| reactome | R-HSA-2172127 | DAP12 interactions |
| reactome | R-HSA-2424491 | DAP12 signaling |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2871796 | FCERI mediated MAPK activation |
| reactome | R-HSA-2871809 | FCERI mediated Ca+2 mobilization |
| reactome | R-HSA-2871809 | FCERI mediated Ca+2 mobilization |
| reactome | R-HSA-5607764 | CLEC7A (Dectin-1) signaling |
| reactome | R-HSA-5607764 | CLEC7A (Dectin-1) signaling |
| reactome | R-HSA-5621480 | Dectin-2 family |
| reactome | R-HSA-5621480 | Dectin-2 family |
| reactome | R-HSA-5621481 | C-type lectin receptors (CLRs) |
| reactome | R-HSA-5621481 | C-type lectin receptors (CLRs) |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD329 | Merck60 | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD158 | NSC141540 | 6 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 1 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD64 | Parbendazole | 6 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD318 | PAC-1 | 5 |
| iGMDRD52 | Rotenone | 1 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD207 | Capsaicin | 1 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD394 | BX-795 | 6 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD549 | Ibrutinib (PCI-32765) | 2 |
| iGMDRD427 | ABT737 | 5 |
| iGMDRD779 | PRL-3 Inhibitor I | 3 |
| iGMDRD546 | BMS-754807 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PLCG2
CLASSFICATION
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