PLCG2


Summary: The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
phospholipase C gamma 2MIM:600220Ensembl:ENSG00000197943HGNC:HGNC:9066PA3339316q23.3

GO terms in PLCG2


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0002092positive regulation of receptor internalization
BPTASGO:0002223stimulatory C-type lectin receptor signaling pathway
BPIEAGO:0002316follicular B cell differentiation
BPIDAGO:0006661phosphatidylinositol biosynthetic process
BPIEAGO:0009395phospholipid catabolic process
BPIEAGO:0010468regulation of gene expression
BPTASGO:0016055Wnt signaling pathway
BPNASGO:0019722calcium-mediated signaling
BPTASGO:0030168platelet activation
BPISSGO:0030183B cell differentiation
BPIEAGO:0032237activation of store-operated calcium channel activity
BPIEAGO:0032481positive regulation of type I interferon production
BPIEAGO:0032496response to lipopolysaccharide
BPIEAGO:0032959inositol trisphosphate biosynthetic process
BPTASGO:0038095Fc-epsilon receptor signaling pathway
BPTASGO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis
BPIEAGO:0043069negative regulation of programmed cell death
BPTASGO:0043647inositol phosphate metabolic process
BPISSGO:0050852T cell receptor signaling pathway
BPISSGO:0050853B cell receptor signaling pathway
BPIDAGO:0051209release of sequestered calcium ion into cytosol
CCTASGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCHDAGO:0070062extracellular exosome
MFIPIGO:0001784phosphotyrosine residue binding
MFIDAGO:0004435phosphatidylinositol phospholipase C activity
MFTASGO:0004435phosphatidylinositol phospholipase C activity
MFTASGO:0004629phospholipase C activity
MFIPIGO:0005515protein binding

Gene expression in normal tissue: PLCG2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PLCG2


DatabasePathway IDPathway Des.
pidar_nongenomic_pathwayNongenotropic Androgen signaling
pidbcr_5pathwayBCR signaling pathway
pidepopathwayEPO signaling pathway
pidpi3kcipathwayClass I PI3K signaling events
pharmgkbPA152530845Proton Pump Inhibitor Pathway, Pharmacodynamics
pharmgkbPA154444041Platelet Aggregation Inhibitor Pathway, Pharmacodynamics
pharmgkbPA162356267EGFR Inhibitor Pathway, Pharmacodynamics
pharmgkbPA2032VEGF Signaling Pathway
netpathPathway_BCRBCR
netpathPathway_CRHCRH
netpathPathway_EGFR1EGFR1
netpathPathway_IL4IL4
netpathPathway_LeptinLeptin
netpathPathway_TCRTCR
kegghsa00562Inositol phosphate metabolism - Homo sapiens (human)
kegghsa04012ErbB signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04020Calcium signaling pathway - Homo sapiens (human)
kegghsa04064NF-kappa B signaling pathway - Homo sapiens (human)
kegghsa04066HIF-1 signaling pathway - Homo sapiens (human)
kegghsa04070Phosphatidylinositol signaling system - Homo sapiens (human)
kegghsa04072Phospholipase D signaling pathway - Homo sapiens (human)
kegghsa04360Axon guidance - Homo sapiens (human)
kegghsa04370VEGF signaling pathway - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04611Platelet activation - Homo sapiens (human)
kegghsa04625C-type lectin receptor signaling pathway - Homo sapiens (human)
kegghsa04650Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegghsa04662B cell receptor signaling pathway - Homo sapiens (human)
kegghsa04664Fc epsilon RI signaling pathway - Homo sapiens (human)
kegghsa04666Fc gamma R-mediated phagocytosis - Homo sapiens (human)
kegghsa04670Leukocyte transendothelial migration - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04750Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa05110Vibrio cholerae infection - Homo sapiens (human)
kegghsa05120Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
humancycLIPASYN-PWYphospholipases
humancycPWY-6351D-myo-inositol (1,4,5)-trisphosphate biosynthesis
humancycPWY-6367D-myo-inositol-5-phosphate metabolism
humancycPWY-6371superpathway of inositol phosphate compounds
wikipathwaysWP2034Leptin signaling pathway
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP23B Cell Receptor Signaling Pathway
wikipathwaysWP2355Corticotropin-releasing hormone signaling pathway
wikipathwaysWP289Myometrial Relaxation and Contraction Pathways
wikipathwaysWP3937Microglia Pathogen Phagocytosis Pathway
wikipathwaysWP3958GPR40 Pathway
wikipathwaysWP4223Ras Signaling
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-114604GPVI-mediated activation cascade
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1483249Inositol phosphate metabolism
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-1855204Synthesis of IP3 and IP4 in the cytosol
reactomeR-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosis
reactomeR-HSA-2029485Role of phospholipids in phagocytosis
reactomeR-HSA-2172127DAP12 interactions
reactomeR-HSA-2424491DAP12 signaling
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2871796FCERI mediated MAPK activation
reactomeR-HSA-2871809FCERI mediated Ca+2 mobilization
reactomeR-HSA-2871809FCERI mediated Ca+2 mobilization
reactomeR-HSA-5607764CLEC7A (Dectin-1) signaling
reactomeR-HSA-5607764CLEC7A (Dectin-1) signaling
reactomeR-HSA-5621480Dectin-2 family
reactomeR-HSA-5621480Dectin-2 family
reactomeR-HSA-5621481C-type lectin receptors (CLRs)
reactomeR-HSA-5621481C-type lectin receptors (CLRs)
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-983695Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
reactomeR-HSA-983705Signaling by the B Cell Receptor (BCR)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD329Merck603
iGMDRD871BRD63683
iGMDRD158NSC1415406
iGMDRD77Itraconazole3
iGMDRD105Triptolide2
iGMDRD434BMS-5369243
iGMDRD341Triacsin c3
iGMDRD945ML2143
iGMDRD154NSC237663
iGMDRD901ELCPK3
iGMDRD123Isoevodiamine1
iGMDRD84Lovastatin acid3
iGMDRD345Compound 10b [PMID: 11504634]1
iGMDRD780PP-303
iGMDRD562Navitoclax6
iGMDRD100Zebularine2
iGMDRD188Piperlongumine4
iGMDRD451Serdemetan2
iGMDRD64Parbendazole6
iGMDRD513BML-2591
iGMDRD318PAC-15
iGMDRD52Rotenone1
iGMDRD187BRD98761
iGMDRD207Capsaicin1
iGMDRD193Fqi11
iGMDRD446LY 21832403
iGMDRD394BX-7956
iGMDRD889Compound 7d-cis2
iGMDRD126Tipifarnib2
iGMDRD549Ibrutinib (PCI-32765)2
iGMDRD427ABT7375
iGMDRD779PRL-3 Inhibitor I3
iGMDRD546BMS-7548073

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PLCG2

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