JARID2
Summary: This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) which plays an essential role in regulating gene expression during embryonic development. This protein facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in multiple transcript variants. Mutations in this gene are associated with chronic myeloid malignancies. [provided by RefSeq, May 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| jumonji and AT-rich interaction domain containing 2 | MIM:601594 | Ensembl:ENSG00000008083 | HGNC:HGNC:6196 | PA29995 | 6p22.3 |
GO terms in JARID2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IBA | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| MF | IEA | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| MF | IBA | GO:0003682 | chromatin binding |
| MF | ISS | GO:0003682 | chromatin binding |
| MF | IEA | GO:0008134 | transcription factor binding |
| MF | IBA | GO:0032452 | histone demethylase activity |
| MF | ISS | GO:0032452 | histone demethylase activity |
| MF | IBA | GO:0034647 | histone demethylase activity (H3-trimethyl-K4 specific) |
| MF | IBA | GO:0035064 | methylated histone binding |
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0001889 | liver development |
| BP | IEA | GO:0006325 | chromatin organization |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | TAS | GO:0007417 | central nervous system development |
| BP | IEA | GO:0010614 | negative regulation of cardiac muscle hypertrophy |
| BP | ISS | GO:0031061 | negative regulation of histone methylation |
| BP | TAS | GO:0045814 | negative regulation of gene expression, epigenetic |
| BP | ISS | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IEA | GO:0048536 | spleen development |
| BP | IEA | GO:0048538 | thymus development |
| BP | ISS | GO:0048863 | stem cell differentiation |
| BP | ISS | GO:0051574 | positive regulation of histone H3-K9 methylation |
| BP | IEA | GO:0060044 | negative regulation of cardiac muscle cell proliferation |
| BP | IEA | GO:1990830 | cellular response to leukemia inhibitory factor |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IBA | GO:0035097 | histone methyltransferase complex |
| CC | ISS | GO:0035097 | histone methyltransferase complex |
| CC | IDA | GO:0035098 | ESC/E(Z) complex |
Gene expression in normal tissue: JARID2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in JARID2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-212165 | Epigenetic regulation of gene expression |
| reactome | R-HSA-212300 | PRC2 methylates histones and DNA |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| wikipathways | WP2853 | Endoderm Differentiation |
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP2916 | Interactome of polycomb repressive complex 2 (PRC2) |
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD79 | Gemcitabine | 4 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD116 | CD437 | 5 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD486 | Tosedostat | 2 |
| iGMDRD154 | NSC23766 | 6 |
| iGMDRD883 | CIL55A | 1 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD177 | Teniposide | 6 |
| iGMDRD123 | Isoevodiamine | 5 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD105 | Triptolide | 4 |
| iGMDRD434 | BMS-536924 | 4 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD158 | NSC141540 | 7 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD322 | FK 866 | 1 |
| iGMDRD886 | Compound 1541A | 1 |
| iGMDRD505 | Pevonedistat | 7 |
| iGMDRD246 | NPC26 | 4 |
| iGMDRD366 | PI-103 | 3 |
| iGMDRD414 | MST-312 | 6 |
| iGMDRD286 | Nsc 632839 | 5 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD433 | Lexibulin | 6 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD297 | Austocystin D | 5 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD193 | Fqi1 | 5 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD885 | Compound 110 | 2 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD187 | BRD9876 | 4 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD260 | FQI-2 | 2 |
| iGMDRD802 | 4-methylfasudil | 2 |
| iGMDRD138 | PX 12 | 4 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD451 | Serdemetan | 4 |
| iGMDRD690 | PRIMA-1MET | 2 |
| iGMDRD60 | Quinoclamine | 1 |
| iGMDRD64 | Parbendazole | 6 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD730 | Kahalalide F | 3 |
| iGMDRD74 | Idarubicin | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in JARID2
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.