XPC


Summary: The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in XPC


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
BP IDA GO:0000715 nucleotide-excision repair, DNA damage recognition
BP TAS GO:0000715 nucleotide-excision repair, DNA damage recognition
BP TAS GO:0006281 DNA repair
BP IBA GO:0006289 nucleotide-excision repair
BP IDA GO:0006289 nucleotide-excision repair
BP TAS GO:0006294 nucleotide-excision repair, preincision complex assembly
Showing 1 to 6 of 32 rows rows per page

Gene expression in normal tissue: XPC

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined32Apoptosis regulation2DNA replication1Chromatin other1Cell cycle1Other, kinases1Proteasome1One carbon pool by folate1

Pathways in XPC


Loading, please wait...
Database
Pathway ID
Pathway Des.
reactome R-HSA-2990846 SUMOylation
reactome R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
reactome R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
reactome R-HSA-392499 Metabolism of proteins
reactome R-HSA-5696394 DNA Damage Recognition in GG-NER
reactome R-HSA-5696395 Formation of Incision Complex in GG-NER
Showing 1 to 6 of 11 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD126 Tipifarnib 3
iGMDRD210 AC55649 3
iGMDRD599 Salermide 1
iGMDRD466 Chaetocin 1
Showing 1 to 4 of 40 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in XPC

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​