LRRK2

Summary: This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameleucine rich repeat kinase 2
OMIM IDMIM:609007
Ensembl IDEnsembl:ENSG00000188906
HGNC IDHGNC:HGNC:18618
PHARMGKB IDPA134968052
Map Location12q12

GO terms in LRRK2


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0000149 SNARE binding
MF IPI GO:0003779 actin binding
MF IDA GO:0003924 GTPase activity
MF IDA GO:0004672 protein kinase activity
MF IDA GO:0004674 protein serine/threonine kinase activity
MF TAS GO:0004674 protein serine/threonine kinase activity
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Gene expression in normal tissue: LRRK2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined68Chromatin histone acetylation2Apoptosis regulation2Biosynthesis of secondary metabolites2Leukocyte transendothelial migration1Cell cycle1p53 pathway1One carbon pool by folate1ERK MAPK signaling1Neuroactive ligand-receptor interaction1

Pathways in LRRK2


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Database
Pathway ID
Pathway Des.
kegg hsa05012 Parkinson,s disease - Homo sapiens (human)
wikipathways WP2328 Allograft Rejection
wikipathways WP2371 Parkinsons Disease Pathway
wikipathways WP3609 Olfactory bulb development and olfactory learning
wikipathways WP382 MAPK Signaling Pathway
wikipathways WP399 Wnt Signaling Pathway and Pluripotency
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD237 ABT-751 6
iGMDRD123 Isoevodiamine 7
iGMDRD945 ML214 4
iGMDRD154 NSC23766 4
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LRRK2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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