LRRK2
Summary: This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:609007 Ensembl IDEnsembl:ENSG00000188906 HGNC IDHGNC:HGNC:18618 PHARMGKB IDPA134968052 Map Location12q12 |
GO terms in LRRK2
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IPI | GO:0000149 | SNARE binding |
MF | IPI | GO:0003779 | actin binding |
MF | IDA | GO:0003924 | GTPase activity |
MF | IDA | GO:0004672 | protein kinase activity |
MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
Gene expression in normal tissue: LRRK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LRRK2
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Database | Pathway ID | Pathway Des. |
---|---|---|
kegg | hsa05012 | Parkinson,s disease - Homo sapiens (human) |
wikipathways | WP2328 | Allograft Rejection |
wikipathways | WP2371 | Parkinsons Disease Pathway |
wikipathways | WP3609 | Olfactory bulb development and olfactory learning |
wikipathways | WP382 | MAPK Signaling Pathway |
wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in LRRK2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |