LRRK2
Summary: This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| leucine rich repeat kinase 2 | MIM:609007 | Ensembl:ENSG00000188906 | HGNC:HGNC:18618 | PA134968052 | 12q12 |
GO terms in LRRK2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0000149 | SNARE binding |
| MF | IPI | GO:0003779 | actin binding |
| MF | IDA | GO:0003924 | GTPase activity |
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004708 | MAP kinase kinase activity |
| MF | IDA | GO:0005096 | GTPase activator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0005525 | GTP binding |
| MF | TAS | GO:0005525 | GTP binding |
| MF | TAS | GO:0008017 | microtubule binding |
| MF | IDA | GO:0015631 | tubulin binding |
| MF | IDA | GO:0016301 | kinase activity |
| MF | IMP | GO:0016301 | kinase activity |
| MF | IBA | GO:0017048 | Rho GTPase binding |
| MF | IPI | GO:0017048 | Rho GTPase binding |
| MF | IPI | GO:0017075 | syntaxin-1 binding |
| MF | IC | GO:0030159 | receptor signaling complex scaffold activity |
| MF | IPI | GO:0030276 | clathrin binding |
| MF | IDA | GO:0034211 | GTP-dependent protein kinase activity |
| MF | IMP | GO:0034211 | GTP-dependent protein kinase activity |
| MF | IDA | GO:0036479 | peroxidase inhibitor activity |
| MF | TAS | GO:0039706 | co-receptor binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IPI | GO:0042803 | protein homodimerization activity |
| MF | IPI | GO:0044325 | ion channel binding |
| MF | IPI | GO:0051018 | protein kinase A binding |
| MF | NAS | GO:1904713 | beta-catenin destruction complex binding |
| CC | HDA | GO:0005615 | extracellular space |
| CC | IMP | GO:0005622 | intracellular |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | ISS | GO:0005741 | mitochondrial outer membrane |
| CC | ISS | GO:0005743 | mitochondrial inner membrane |
| CC | ISS | GO:0005759 | mitochondrial matrix |
| CC | IBA | GO:0005764 | lysosome |
| CC | ISS | GO:0005764 | lysosome |
| CC | IBA | GO:0005768 | endosome |
| CC | ISS | GO:0005768 | endosome |
| CC | IBA | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | ISS | GO:0005783 | endoplasmic reticulum |
| CC | IBA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | ISS | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005798 | Golgi-associated vesicle |
| CC | IEA | GO:0005802 | trans-Golgi network |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005902 | microvillus |
| CC | IMP | GO:0016234 | inclusion body |
| CC | IEA | GO:0030054 | cell junction |
| CC | IDA | GO:0030424 | axon |
| CC | ISS | GO:0030424 | axon |
| CC | IDA | GO:0030425 | dendrite |
| CC | ISS | GO:0030425 | dendrite |
| CC | IDA | GO:0030426 | growth cone |
| CC | IEA | GO:0030672 | synaptic vesicle membrane |
| CC | ISS | GO:0031410 | cytoplasmic vesicle |
| CC | IBA | GO:0031966 | mitochondrial membrane |
| CC | IDA | GO:0031966 | mitochondrial membrane |
| CC | IDA | GO:0032473 | cytoplasmic side of mitochondrial outer membrane |
| CC | IDA | GO:0032839 | dendrite cytoplasm |
| CC | IBA | GO:0043005 | neuron projection |
| CC | IDA | GO:0043005 | neuron projection |
| CC | IDA | GO:0043025 | neuronal cell body |
| CC | TAS | GO:0043195 | terminal bouton |
| CC | IDA | GO:0043204 | perikaryon |
| CC | ISS | GO:0043204 | perikaryon |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IDA | GO:0044753 | amphisome |
| CC | IDA | GO:0044754 | autolysosome |
| CC | IBA | GO:0045121 | membrane raft |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IDA | GO:0097487 | multivesicular body, internal vesicle |
| CC | IEA | GO:0098794 | postsynapse |
| CC | IDA | GO:0099400 | caveola neck |
| CC | IEA | GO:1990904 | ribonucleoprotein complex |
| CC | IDA | GO:1990909 | Wnt signalosome |
| CC | NAS | GO:1990909 | Wnt signalosome |
| BP | IDA | GO:0000165 | MAPK cascade |
| BP | IDA | GO:0000186 | activation of MAPKK activity |
| BP | IMP | GO:0000187 | activation of MAPK activity |
| BP | ISS | GO:0001933 | negative regulation of protein phosphorylation |
| BP | IDA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IMP | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IMP | GO:0006468 | protein phosphorylation |
| BP | IGI | GO:0006897 | endocytosis |
| BP | IMP | GO:0006897 | endocytosis |
| BP | IEA | GO:0006914 | autophagy |
| BP | IMP | GO:0006979 | response to oxidative stress |
| BP | IBA | GO:0007005 | mitochondrion organization |
| BP | IMP | GO:0007005 | mitochondrion organization |
| BP | IMP | GO:0007030 | Golgi organization |
| BP | IMP | GO:0007040 | lysosome organization |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | IMP | GO:0007528 | neuromuscular junction development |
| BP | IMP | GO:0008340 | determination of adult lifespan |
| BP | IMP | GO:0009267 | cellular response to starvation |
| BP | IMP | GO:0010506 | regulation of autophagy |
| BP | IMP | GO:0010508 | positive regulation of autophagy |
| BP | ISS | GO:0010508 | positive regulation of autophagy |
| BP | ISS | GO:0010738 | regulation of protein kinase A signaling |
| BP | IDA | GO:0010955 | negative regulation of protein processing |
| BP | IEA | GO:0010977 | negative regulation of neuron projection development |
| BP | IMP | GO:0014041 | regulation of neuron maturation |
| BP | IMP | GO:0016242 | negative regulation of macroautophagy |
| BP | IMP | GO:0016310 | phosphorylation |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0018107 | peptidyl-threonine phosphorylation |
| BP | IMP | GO:0018107 | peptidyl-threonine phosphorylation |
| BP | IBA | GO:0019722 | calcium-mediated signaling |
| BP | IMP | GO:0019722 | calcium-mediated signaling |
| BP | IEA | GO:0021756 | striatum development |
| BP | IMP | GO:0021772 | olfactory bulb development |
| BP | IMP | GO:0022028 | tangential migration from the subventricular zone to the olfactory bulb |
| BP | IDA | GO:0031398 | positive regulation of protein ubiquitination |
| BP | IMP | GO:0032091 | negative regulation of protein binding |
| BP | IDA | GO:0032092 | positive regulation of protein binding |
| BP | ISS | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | IEA | GO:0033160 | positive regulation of protein import into nucleus, translocation |
| BP | IDA | GO:0034260 | negative regulation of GTPase activity |
| BP | IMP | GO:0034599 | cellular response to oxidative stress |
| BP | ISS | GO:0034613 | cellular protein localization |
| BP | ISS | GO:0035556 | intracellular signal transduction |
| BP | ISS | GO:0035564 | regulation of kidney size |
| BP | IMP | GO:0035640 | exploration behavior |
| BP | IEA | GO:0035641 | locomotory exploration behavior |
| BP | IMP | GO:0035751 | regulation of lysosomal lumen pH |
| BP | IMP | GO:0040012 | regulation of locomotion |
| BP | IMP | GO:0042391 | regulation of membrane potential |
| BP | IDA | GO:0043068 | positive regulation of programmed cell death |
| BP | IC | GO:0043406 | positive regulation of MAP kinase activity |
| BP | IEA | GO:0043547 | positive regulation of GTPase activity |
| BP | IDA | GO:0046039 | GTP metabolic process |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IMP | GO:0046777 | protein autophosphorylation |
| BP | IMP | GO:0048312 | intracellular distribution of mitochondria |
| BP | IMP | GO:0048812 | neuron projection morphogenesis |
| BP | IMP | GO:0051646 | mitochondrion localization |
| BP | IEA | GO:0051770 | positive regulation of nitric-oxide synthase biosynthetic process |
| BP | IMP | GO:0051900 | regulation of mitochondrial depolarization |
| BP | ISS | GO:0051966 | regulation of synaptic transmission, glutamatergic |
| BP | TAS | GO:0060070 | canonical Wnt signaling pathway |
| BP | ISS | GO:0060079 | excitatory postsynaptic potential |
| BP | ISS | GO:0060159 | regulation of dopamine receptor signaling pathway |
| BP | IMP | GO:0060161 | positive regulation of dopamine receptor signaling pathway |
| BP | TAS | GO:0060828 | regulation of canonical Wnt signaling pathway |
| BP | IBA | GO:0061001 | regulation of dendritic spine morphogenesis |
| BP | IMP | GO:0061001 | regulation of dendritic spine morphogenesis |
| BP | ISS | GO:0061001 | regulation of dendritic spine morphogenesis |
| BP | TAS | GO:0070585 | protein localization to mitochondrion |
| BP | IMP | GO:0070997 | neuron death |
| BP | IMP | GO:0071287 | cellular response to manganese ion |
| BP | IMP | GO:0072593 | reactive oxygen species metabolic process |
| BP | TAS | GO:0090140 | regulation of mitochondrial fission |
| BP | IGI | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| BP | ISS | GO:0090394 | negative regulation of excitatory postsynaptic potential |
| BP | IEA | GO:0140058 | neuron projection arborization |
| BP | IEA | GO:1900244 | positive regulation of synaptic vesicle endocytosis |
| BP | IMP | GO:1901214 | regulation of neuron death |
| BP | IGI | GO:1901215 | negative regulation of neuron death |
| BP | IEA | GO:1901727 | positive regulation of histone deacetylase activity |
| BP | IMP | GO:1902236 | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
| BP | IDA | GO:1902499 | positive regulation of protein autoubiquitination |
| BP | IMP | GO:1902692 | regulation of neuroblast proliferation |
| BP | IBA | GO:1902803 | regulation of synaptic vesicle transport |
| BP | ISS | GO:1902803 | regulation of synaptic vesicle transport |
| BP | TAS | GO:1902803 | regulation of synaptic vesicle transport |
| BP | TAS | GO:1902823 | negative regulation of late endosome to lysosome transport |
| BP | IBA | GO:1902902 | negative regulation of autophagosome assembly |
| BP | IMP | GO:1902902 | negative regulation of autophagosome assembly |
| BP | IDA | GO:1903125 | negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation |
| BP | IMP | GO:1903206 | negative regulation of hydrogen peroxide-induced cell death |
| BP | IDA | GO:1903215 | negative regulation of protein targeting to mitochondrion |
| BP | IC | GO:1903217 | negative regulation of protein processing involved in protein targeting to mitochondrion |
| BP | IMP | GO:1903351 | cellular response to dopamine |
| BP | IEA | GO:1903980 | positive regulation of microglial cell activation |
| BP | IEA | GO:1904469 | positive regulation of tumor necrosis factor secretion |
| BP | IPI | GO:1904887 | Wnt signalosome assembly |
| BP | TAS | GO:1904887 | Wnt signalosome assembly |
| BP | IBA | GO:1905279 | regulation of retrograde transport, endosome to Golgi |
| BP | IGI | GO:1905279 | regulation of retrograde transport, endosome to Golgi |
| BP | IMP | GO:1905289 | regulation of CAMKK-AMPK signaling cascade |
| BP | IMP | GO:2000172 | regulation of branching morphogenesis of a nerve |
| BP | IMP | GO:2000300 | regulation of synaptic vesicle exocytosis |
Gene expression in normal tissue: LRRK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LRRK2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa05012 | Parkinson,s disease - Homo sapiens (human) |
| wikipathways | WP2328 | Allograft Rejection |
| wikipathways | WP2371 | Parkinsons Disease Pathway |
| wikipathways | WP3609 | Olfactory bulb development and olfactory learning |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-8848021 | Signaling by PTK6 |
| reactome | R-HSA-8857538 | PTK6 promotes HIF1A stabilization |
| reactome | R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD237 | ABT-751 | 6 |
| iGMDRD123 | Isoevodiamine | 7 |
| iGMDRD945 | ML214 | 4 |
| iGMDRD154 | NSC23766 | 4 |
| iGMDRD48 | Dexamethasone | 2 |
| iGMDRD330 | BRD4132 | 4 |
| iGMDRD150 | RITA | 5 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD583 | LDN 193189 | 1 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD286 | Nsc 632839 | 5 |
| iGMDRD552 | AZD-1775 | 2 |
| iGMDRD263 | AACOCF3 | 4 |
| iGMDRD322 | FK 866 | 4 |
| iGMDRD137 | Indisulam | 5 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD121 | GMX1778 | 1 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD289 | Parthenolide | 6 |
| iGMDRD213 | SMR000068650 | 3 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD466 | Chaetocin | 11 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD433 | Lexibulin | 6 |
| iGMDRD151 | CHM-1 | 4 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD781 | Sirolimus | 4 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD74 | Idarubicin | 4 |
| iGMDRD224 | Necrostatin-1 | 3 |
| iGMDRD780 | PP-30 | 5 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD524 | ISX-9 | 6 |
| iGMDRD260 | FQI-2 | 2 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD187 | BRD9876 | 4 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD351 | GW843682X | 8 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD486 | Tosedostat | 1 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD116 | CD437 | 5 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 1 |
| iGMDRD882 | CIL41 | 2 |
| iGMDRD505 | Pevonedistat | 6 |
| iGMDRD246 | NPC26 | 4 |
| iGMDRD42 | Vorinostat | 2 |
| iGMDRD434 | BMS-536924 | 7 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD201 | SKI II | 5 |
| iGMDRD193 | Fqi1 | 4 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD280 | CYTOCHALASIN B | 5 |
| iGMDRD375 | GW-405833 | 6 |
| iGMDRD634 | SCHEMBL2608041 | 12 |
| iGMDRD380 | Pifithrin-alpha | 3 |
| iGMDRD599 | Salermide | 5 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD494 | Neopeltolide | 1 |
| iGMDRD100 | Zebularine | 6 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD562 | Navitoclax | 4 |
| iGMDRD398 | Sepantronium | 1 |
| iGMDRD268 | Cerulenin | 3 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD138 | PX 12 | 4 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD885 | Compound 110 | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LRRK2
CLASSFICATION
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