ACACB
Summary: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:601557 Ensembl IDEnsembl:ENSG00000076555 HGNC IDHGNC:HGNC:85 PHARMGKB IDPA24422 Map Location12q24.11 | |||||
GO terms in ACACB
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0003989 | acetyl-CoA carboxylase activity |
| MF | TAS | GO:0003989 | acetyl-CoA carboxylase activity |
| MF | IEA | GO:0004075 | biotin carboxylase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0009374 | biotin binding |
Gene expression in normal tissue: ACACB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ACACB
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA165948566 | Metformin Pathway, Pharmacodynamic |
| humancyc | PWY-5966-1 | fatty acid biosynthesis initiation |
| humancyc | PWY0-1264 | biotin-carboxyl carrier protein assembly |
| netpath | Pathway_Leptin | Leptin |
| kegg | hsa00061 | Fatty acid biosynthesis - Homo sapiens (human) |
| kegg | hsa00620 | Pyruvate metabolism - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ACACB
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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