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ACACB

Summary: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
acetyl-CoA carboxylase beta	MIM:601557	Ensembl:ENSG00000076555	HGNC:HGNC:85	PA24422	12q24.11

Gene Categories:

DRUGGABLE GENOME DRUG RESISTANCE

GO terms in ACACB

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IDA	GO:0003989	acetyl-CoA carboxylase activity
MF	TAS	GO:0003989	acetyl-CoA carboxylase activity
MF	IEA	GO:0004075	biotin carboxylase activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding
MF	IEA	GO:0009374	biotin binding
MF	IPI	GO:0042802	identical protein binding
MF	IEA	GO:0046872	metal ion binding
BP	IDA	GO:0006084	acetyl-CoA metabolic process
BP	IEA	GO:0006633	fatty acid biosynthetic process
BP	TAS	GO:0006853	carnitine shuttle
BP	IEA	GO:0010629	negative regulation of gene expression
BP	IEA	GO:0010884	positive regulation of lipid storage
BP	IEA	GO:0010906	regulation of glucose metabolic process
BP	IEA	GO:0014070	response to organic cyclic compound
BP	TAS	GO:0031325	positive regulation of cellular metabolic process
BP	IEA	GO:0031667	response to nutrient levels
BP	IEA	GO:0031999	negative regulation of fatty acid beta-oxidation
BP	IEA	GO:0042493	response to drug
BP	IEA	GO:0043086	negative regulation of catalytic activity
BP	TAS	GO:0045540	regulation of cholesterol biosynthetic process
BP	IDA	GO:0051289	protein homotetramerization
BP	IEA	GO:0060421	positive regulation of heart growth
BP	IEA	GO:0097009	energy homeostasis
BP	IEA	GO:2001295	malonyl-CoA biosynthetic process
CC	IDA	GO:0005634	nucleus
CC	IDA	GO:0005739	mitochondrion
CC	TAS	GO:0005741	mitochondrial outer membrane
CC	TAS	GO:0005829	cytosol
CC	IEA	GO:0012505	endomembrane system

Gene expression in normal tissue: ACACB

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ACACB

Database	Pathway ID	Pathway Des.
pharmgkb	PA165948566	Metformin Pathway, Pharmacodynamic
humancyc	PWY-5966-1	fatty acid biosynthesis initiation
humancyc	PWY0-1264	biotin-carboxyl carrier protein assembly
netpath	Pathway_Leptin	Leptin
kegg	hsa00061	Fatty acid biosynthesis - Homo sapiens (human)
kegg	hsa00620	Pyruvate metabolism - Homo sapiens (human)
kegg	hsa00640	Propanoate metabolism - Homo sapiens (human)
kegg	hsa04152	AMPK signaling pathway - Homo sapiens (human)
kegg	hsa04910	Insulin signaling pathway - Homo sapiens (human)
kegg	hsa04920	Adipocytokine signaling pathway - Homo sapiens (human)
kegg	hsa04922	Glucagon signaling pathway - Homo sapiens (human)
kegg	hsa04931	Insulin resistance - Homo sapiens (human)
wikipathways	WP1403	AMP-activated Protein Kinase (AMPK) Signaling
wikipathways	WP2034	Leptin signaling pathway
wikipathways	WP2380	Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathways	WP2593	JAK-STAT
wikipathways	WP2706	Activation of gene expression by SREBF (SREBP)
wikipathways	WP357	Fatty Acid Biosynthesis
wikipathways	WP3888	VEGFA-VEGFR2 Signaling Pathway
wikipathways	WP4010	Liver steatosis AOP
wikipathways	WP4018	Pathways in clear cell renal cell carcinoma
wikipathways	WP4206	Hereditary Leiomyomatosis and Renal Cell Carcinoma Pathway
reactome	R-HSA-1430728	Metabolism
reactome	R-HSA-163685	Integration of energy metabolism
reactome	R-HSA-163765	ChREBP activates metabolic gene expression
reactome	R-HSA-1655829	Regulation of cholesterol biosynthesis by SREBP (SREBF)
reactome	R-HSA-196780	Biotin transport and metabolism
reactome	R-HSA-196849	Metabolism of water-soluble vitamins and cofactors
reactome	R-HSA-196854	Metabolism of vitamins and cofactors
reactome	R-HSA-200425	Import of palmitoyl-CoA into the mitochondrial matrix
reactome	R-HSA-2426168	Activation of gene expression by SREBF (SREBP)
reactome	R-HSA-556833	Metabolism of lipids
reactome	R-HSA-8957322	Metabolism of steroids
reactome	R-HSA-8978868	Fatty acid metabolism

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD188	Piperlongumine	3
iGMDRD399	Selumetinib	2
iGMDRD74	Idarubicin	1
iGMDRD577	BIX01294	4
iGMDRD562	Navitoclax	4
iGMDRD60	Quinoclamine	2
iGMDRD640	CAY10618	3
iGMDRD64	Parbendazole	4
iGMDRD451	Serdemetan	2
iGMDRD138	PX 12	1
iGMDRD255	SB225002	2
iGMDRD171	Pemetrexed	1
iGMDRD782	DC-45-A2	4
iGMDRD441	TW 37	2
iGMDRD885	Compound 110	2
iGMDRD187	BRD9876	1
iGMDRD446	LY 2183240	5
iGMDRD71	Sparfosic acid	2
iGMDRD639	YK 4-279	1
iGMDRD193	Fqi1	3
iGMDRD61	Kinetin riboside	4
iGMDRD280	CYTOCHALASIN B	4
iGMDRD394	BX-795	4
iGMDRD466	Chaetocin	3
iGMDRD634	SCHEMBL2608041	2
iGMDRD554	CHEMBL1434137	2
iGMDRD599	Salermide	2
iGMDRD387	CHIR-99021	1
iGMDRD229	B02	3
iGMDRD427	ABT737	1
iGMDRD781	Sirolimus	2
iGMDRD82	Quiflapon	2
iGMDRD322	FK 866	3
iGMDRD121	GMX1778	6
iGMDRD158	NSC141540	3
iGMDRD6	AM-580	3
iGMDRD289	Parthenolide	3
iGMDRD434	BMS-536924	2
iGMDRD231	Importazole	3
iGMDRD85	Ursolic acid	3
iGMDRD901	ELCPK	1
iGMDRD177	Teniposide	2
iGMDRD84	Lovastatin acid	4
iGMDRD486	Tosedostat	1
iGMDRD512	nutlin 3	1
iGMDRD532	Olaparib	2
iGMDRD560	MK-2206	3
iGMDRD345	Compound 10b [PMID: 11504634]	2
iGMDRD299	ICL 670	1
iGMDRD79	Gemcitabine	7

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ACACB

SITE

DATATYPES

CLASSFICATION

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