NUDT10
Summary: This gene is a member of the nudix (nucleoside diphosphate linked moiety X)-type motif containing family. The encoded protein is a phosphohydrolase and may regulate the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to the regulation of intracellular trafficking. In some populations putative prostate cancer susceptibility alleles have been identified for this gene. Alternatively spliced transcript variants, which differ only in the 5' UTR, have been found for this gene. [provided by RefSeq, Feb 2015].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:300527 Ensembl IDEnsembl:ENSG00000122824 HGNC IDHGNC:HGNC:17621 PHARMGKB IDPA31831 Map LocationXp11.22 | |||||
GO terms in NUDT10
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000298 | endopolyphosphatase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008486 | diphosphoinositol-polyphosphate diphosphatase activity |
| MF | ISS | GO:0008486 | diphosphoinositol-polyphosphate diphosphatase activity |
| MF | IBA | GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| MF | IBA | GO:0034431 | bis(5'-adenosyl)-hexaphosphatase activity |
Gene expression in normal tissue: NUDT10
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NUDT10
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1483249 | Inositol phosphate metabolism |
| reactome | R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NUDT10
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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