ADK
Summary: This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| adenosine kinase | MIM:102750 | Ensembl:ENSG00000156110 | HGNC:HGNC:257 | PA24579 | 10q22.2|10q11-q24 |
GO terms in ADK
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| BP | IEA | GO:0006175 | dATP biosynthetic process |
| BP | TAS | GO:0009156 | ribonucleoside monophosphate biosynthetic process |
| BP | TAS | GO:0043101 | purine-containing compound salvage |
| BP | IEA | GO:0044209 | AMP salvage |
| MF | HDA | GO:0003723 | RNA binding |
| MF | EXP | GO:0004001 | adenosine kinase activity |
| MF | IBA | GO:0004001 | adenosine kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: ADK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ADK
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00230 | Purine metabolism - Homo sapiens (human) |
| pharmgkb | PA166104634 | Abacavir Pathway, Pharmacokinetics/Pharmacodynamics |
| pharmgkb | PA2040 | Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics |
| humancyc | PWY-6619 | adenine and adenosine salvage II |
| humancyc | PWY66-409 | superpathway of purine nucleotide salvage |
| smpdb | SMP00427 | Azathioprine Action Pathway |
| smpdb | SMP00428 | Mercaptopurine Action Pathway |
| smpdb | SMP00430 | Thioguanine Action Pathway |
| smpdb | SMP00609 | Mercaptopurine Metabolism Pathway |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-15869 | Metabolism of nucleotides |
| reactome | R-HSA-74217 | Purine salvage |
| reactome | R-HSA-8956321 | Nucleotide salvage |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD483 | SCH-529074 | 1 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD466 | Chaetocin | 1 |
| iGMDRD247 | Blebbistatin | 4 |
| iGMDRD513 | BML-259 | 2 |
| iGMDRD294 | Batimastat | 1 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 6 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD224 | Necrostatin-1 | 3 |
| iGMDRD730 | Kahalalide F | 2 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD524 | ISX-9 | 6 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD23 | Gossypol | 6 |
| iGMDRD64 | Parbendazole | 4 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD150 | RITA | 1 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD219 | Bax channel blocker | 3 |
| iGMDRD314 | Tanespimycin | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD158 | NSC141540 | 5 |
| iGMDRD137 | Indisulam | 5 |
| iGMDRD121 | GMX1778 | 5 |
| iGMDRD213 | SMR000068650 | 6 |
| iGMDRD329 | Merck60 | 15 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD871 | BRD6368 | 8 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD772 | BRD4770 | 9 |
| iGMDRD387 | CHIR-99021 | 3 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD718 | Pyrvinium pamoate | 1 |
| iGMDRD201 | SKI II | 2 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD380 | Pifithrin-alpha | 6 |
| iGMDRD375 | GW-405833 | 4 |
| iGMDRD634 | SCHEMBL2608041 | 11 |
| iGMDRD280 | CYTOCHALASIN B | 6 |
| iGMDRD802 | 4-methylfasudil | 10 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD318 | PAC-1 | 8 |
| iGMDRD577 | BIX01294 | 9 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD451 | Serdemetan | 5 |
| iGMDRD444 | Tivantinib | 3 |
| iGMDRD268 | Cerulenin | 6 |
| iGMDRD60 | Quinoclamine | 9 |
| iGMDRD690 | PRIMA-1MET | 9 |
| iGMDRD148 | Pifithrin-mu | 5 |
| iGMDRD607 | Ubistatin B | 4 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 4 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 1 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD269 | Purmorphamine | 2 |
| iGMDRD872 | BRD7137 | 1 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD300 | Tozasertib | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ADK
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