ADK


Summary: This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
adenosine kinaseMIM:102750Ensembl:ENSG00000156110HGNC:HGNC:257PA2457910q22.2|10q11-q24

Gene Categories:

DRUGGABLE GENOMEKINASE

GO terms in ADK


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIBAGO:0005829cytosol
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
BPIEAGO:0006175dATP biosynthetic process
BPTASGO:0009156ribonucleoside monophosphate biosynthetic process
BPTASGO:0043101purine-containing compound salvage
BPIEAGO:0044209AMP salvage
MFHDAGO:0003723RNA binding
MFEXPGO:0004001adenosine kinase activity
MFIBAGO:0004001adenosine kinase activity
MFIEAGO:0005524ATP binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: ADK

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ADK


DatabasePathway IDPathway Des.
kegghsa00230Purine metabolism - Homo sapiens (human)
pharmgkbPA166104634Abacavir Pathway, Pharmacokinetics/Pharmacodynamics
pharmgkbPA2040Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics
humancycPWY-6619adenine and adenosine salvage II
humancycPWY66-409superpathway of purine nucleotide salvage
smpdbSMP00427Azathioprine Action Pathway
smpdbSMP00428Mercaptopurine Action Pathway
smpdbSMP00430Thioguanine Action Pathway
smpdbSMP00609Mercaptopurine Metabolism Pathway
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-15869Metabolism of nucleotides
reactomeR-HSA-74217Purine salvage
reactomeR-HSA-8956321Nucleotide salvage

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD126Tipifarnib4
iGMDRD483SCH-5290741
iGMDRD546BMS-7548073
iGMDRD427ABT7372
iGMDRD639YK 4-2793
iGMDRD466Chaetocin1
iGMDRD247Blebbistatin4
iGMDRD513BML-2592
iGMDRD294Batimastat1
iGMDRD8012,4-dideoxy-DC-45-A26
iGMDRD506Fedratinib3
iGMDRD224Necrostatin-13
iGMDRD730Kahalalide F2
iGMDRD74Idarubicin3
iGMDRD524ISX-96
iGMDRD356PNU-746543
iGMDRD23Gossypol6
iGMDRD64Parbendazole4
iGMDRD79Gemcitabine2
iGMDRD150RITA1
iGMDRD532Olaparib3
iGMDRD237ABT-7513
iGMDRD219Bax channel blocker3
iGMDRD314Tanespimycin2
iGMDRD123Isoevodiamine3
iGMDRD158NSC1415405
iGMDRD137Indisulam5
iGMDRD121GMX17785
iGMDRD213SMR0000686506
iGMDRD329Merck6015
iGMDRD367Ro 28-16753
iGMDRD286Nsc 6328393
iGMDRD871BRD63688
iGMDRD322FK 8662
iGMDRD147Prima-13
iGMDRD579PF7503
iGMDRD772BRD47709
iGMDRD387CHIR-990213
iGMDRD193Fqi11
iGMDRD718Pyrvinium pamoate1
iGMDRD201SKI II2
iGMDRD446LY 21832404
iGMDRD380Pifithrin-alpha6
iGMDRD375GW-4058334
iGMDRD634SCHEMBL260804111
iGMDRD280CYTOCHALASIN B6
iGMDRD8024-methylfasudil10
iGMDRD870BRD636102
iGMDRD318PAC-18
iGMDRD577BIX012949
iGMDRD887Compound 23 citrate2
iGMDRD451Serdemetan5
iGMDRD444Tivantinib3
iGMDRD268Cerulenin6
iGMDRD60Quinoclamine9
iGMDRD690PRIMA-1MET9
iGMDRD148Pifithrin-mu5
iGMDRD607Ubistatin B4
iGMDRD512nutlin 32
iGMDRD307Manumycin A3
iGMDRD701NVP-AUY9222
iGMDRD345Compound 10b [PMID: 11504634]4
iGMDRD424Tamatinib2
iGMDRD351GW843682X2
iGMDRD177Teniposide3
iGMDRD211(1S,3R)-RSL31
iGMDRD901ELCPK3
iGMDRD434BMS-5369242
iGMDRD269Purmorphamine2
iGMDRD872BRD71371
iGMDRD82Quiflapon2
iGMDRD300Tozasertib3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ADK

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