ADK
Summary: This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Nameadenosine kinase OMIM IDMIM:102750 Ensembl IDEnsembl:ENSG00000156110 HGNC IDHGNC:HGNC:257 PHARMGKB IDPA24579 Map Location10q22.2|10q11-q24 | |||||
GO terms in ADK
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| BP | IEA | GO:0006175 | dATP biosynthetic process |
Gene expression in normal tissue: ADK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ADK
Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00230 | Purine metabolism - Homo sapiens (human) |
| pharmgkb | PA166104634 | Abacavir Pathway, Pharmacokinetics/Pharmacodynamics |
| pharmgkb | PA2040 | Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics |
| humancyc | PWY-6619 | adenine and adenosine salvage II |
| humancyc | PWY66-409 | superpathway of purine nucleotide salvage |
| smpdb | SMP00427 | Azathioprine Action Pathway |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ADK
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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