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IKBKB

Summary: The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameinhibitor of nuclear factor kappa B kinase subunit beta OMIM IDMIM:603258 Ensembl IDEnsembl:ENSG00000104365 HGNC IDHGNC:HGNC:5960 PHARMGKB IDPA29776 Map Location8p11.21

Gene Categories:

PROTEIN PHOSPHATASE DRUGGABLE GENOME SERINE THREONINE KINASE KINASE

GO terms in IKBKB

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	TAS	GO:0002223	stimulatory C-type lectin receptor signaling pathway
BP	TAS	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
BP	TAS	GO:0002756	MyD88-independent toll-like receptor signaling pathway
BP	IDA	GO:0006468	protein phosphorylation
BP	NAS	GO:0006468	protein phosphorylation
BP	TAS	GO:0006954	inflammatory response

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Gene expression in normal tissue: IKBKB

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IKBKB

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)
reactome	R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)
reactome	R-HSA-1169091	Activation of NF-kappaB in B cells
reactome	R-HSA-1169091	Activation of NF-kappaB in B cells
reactome	R-HSA-1236974	ER-Phagosome pathway
reactome	R-HSA-1236975	Antigen processing-Cross presentation

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD60	Quinoclamine	2
iGMDRD64	Parbendazole	3
iGMDRD23	Gossypol	3
iGMDRD444	Tivantinib	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IKBKB

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.