IKBKB


Summary: The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
inhibitor of nuclear factor kappa B kinase subunit betaMIM:603258Ensembl:ENSG00000104365HGNC:HGNC:5960PA297768p11.21

GO terms in IKBKB


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0002223stimulatory C-type lectin receptor signaling pathway
BPTASGO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
BPTASGO:0002756MyD88-independent toll-like receptor signaling pathway
BPIDAGO:0006468protein phosphorylation
BPNASGO:0006468protein phosphorylation
BPTASGO:0006954inflammatory response
BPIMPGO:0007249I-kappaB kinase/NF-kappaB signaling
BPTASGO:0007249I-kappaB kinase/NF-kappaB signaling
BPIEAGO:0007252I-kappaB phosphorylation
BPTASGO:0009615response to virus
BPIBAGO:0009653anatomical structure morphogenesis
BPTASGO:0010803regulation of tumor necrosis factor-mediated signaling pathway
BPIBAGO:0018105peptidyl-serine phosphorylation
BPIDAGO:0018105peptidyl-serine phosphorylation
BPIMPGO:0030866cortical actin cytoskeleton organization
BPIBAGO:0033209tumor necrosis factor-mediated signaling pathway
BPIMPGO:0033209tumor necrosis factor-mediated signaling pathway
BPIMPGO:0035509negative regulation of myosin-light-chain-phosphatase activity
BPTASGO:0035666TRIF-dependent toll-like receptor signaling pathway
BPTASGO:0038095Fc-epsilon receptor signaling pathway
BPIDAGO:0042325regulation of phosphorylation
BPTASGO:0043066negative regulation of apoptotic process
BPTASGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPTASGO:0045087innate immune response
BPNASGO:0045893positive regulation of transcription, DNA-templated
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPTASGO:0050852T cell receptor signaling pathway
BPIBAGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIDAGO:0051092positive regulation of NF-kappaB transcription factor activity
BPTASGO:0051092positive regulation of NF-kappaB transcription factor activity
BPTASGO:0051403stress-activated MAPK cascade
BPIMPGO:0070498interleukin-1-mediated signaling pathway
BPTASGO:0070498interleukin-1-mediated signaling pathway
BPIDAGO:0071356cellular response to tumor necrosis factor
BPIMPGO:0072659protein localization to plasma membrane
BPIMPGO:1903140regulation of establishment of endothelial barrier
BPIMPGO:1903347negative regulation of bicellular tight junction assembly
CCIEAGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIBAGO:0008385IkappaB kinase complex
CCTASGO:0008385IkappaB kinase complex
CCISSGO:0009898cytoplasmic side of plasma membrane
CCISSGO:0035631CD40 receptor complex
CCIEAGO:0045121membrane raft
MFIDAGO:0004672protein kinase activity
MFEXPGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0008384IkappaB kinase activity
MFTASGO:0008384IkappaB kinase activity
MFIPIGO:0019901protein kinase binding
MFIPIGO:0042802identical protein binding
MFIDAGO:0042803protein homodimerization activity
MFIDAGO:0046982protein heterodimerization activity
MFIDAGO:0097110scaffold protein binding

Gene expression in normal tissue: IKBKB

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IKBKB


DatabasePathway IDPathway Des.
reactomeR-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)
reactomeR-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)
reactomeR-HSA-1169091Activation of NF-kappaB in B cells
reactomeR-HSA-1169091Activation of NF-kappaB in B cells
reactomeR-HSA-1236974ER-Phagosome pathway
reactomeR-HSA-1236975Antigen processing-Cross presentation
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1606322ZBP1(DAI) mediated induction of type I IFNs
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-166058MyD88:Mal cascade initiated on plasma membrane
reactomeR-HSA-166166MyD88-independent TLR4 cascade
reactomeR-HSA-168138Toll Like Receptor 9 (TLR9) Cascade
reactomeR-HSA-168142Toll Like Receptor 10 (TLR10) Cascade
reactomeR-HSA-168164Toll Like Receptor 3 (TLR3) Cascade
reactomeR-HSA-168176Toll Like Receptor 5 (TLR5) Cascade
reactomeR-HSA-168179Toll Like Receptor TLR1:TLR2 Cascade
reactomeR-HSA-168181Toll Like Receptor 7/8 (TLR7/8) Cascade
reactomeR-HSA-168188Toll Like Receptor TLR6:TLR2 Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168638NOD1/2 Signaling Pathway
reactomeR-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-168927TICAM1, RIP1-mediated IKK complex recruitment
reactomeR-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/beta
reactomeR-HSA-1810476RIP-mediated NFkB activation via ZBP1
reactomeR-HSA-181438Toll Like Receptor 2 (TLR2) Cascade
reactomeR-HSA-1834949Cytosolic sensors of pathogen-associated DNA
reactomeR-HSA-193639p75NTR signals via NF-kB
reactomeR-HSA-193704p75 NTR receptor-mediated signalling
reactomeR-HSA-202403TCR signaling
reactomeR-HSA-202424Downstream TCR signaling
reactomeR-HSA-209543p75NTR recruits signalling complexes
reactomeR-HSA-209560NF-kB is activated and signals survival
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2871837FCERI mediated NF-kB activation
reactomeR-HSA-445989TAK1 activates NFkB by phosphorylation and activation of IKKs complex
reactomeR-HSA-446652Interleukin-1 family signaling
reactomeR-HSA-448424Interleukin-17 signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-450294MAP kinase activation
reactomeR-HSA-5260271Diseases of Immune System
reactomeR-HSA-5357905Regulation of TNFR1 signaling
reactomeR-HSA-5357956TNFR1-induced NFkappaB signaling pathway
reactomeR-HSA-5602358Diseases associated with the TLR signaling cascade
reactomeR-HSA-5602636IKBKB deficiency causes SCID
reactomeR-HSA-5603027IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
reactomeR-HSA-5603029IkBA variant leads to EDA-ID
reactomeR-HSA-5607764CLEC7A (Dectin-1) signaling
reactomeR-HSA-5621481C-type lectin receptors (CLRs)
reactomeR-HSA-5684264MAP3K8 (TPL2)-dependent MAPK1/3 activation
reactomeR-HSA-73887Death Receptor Signalling
reactomeR-HSA-75893TNF signaling
reactomeR-HSA-9020702Interleukin-1 signaling
reactomeR-HSA-933542TRAF6 mediated NF-kB activation
reactomeR-HSA-933543NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
reactomeR-HSA-937039IRAK1 recruits IKK complex
reactomeR-HSA-937041IKK complex recruitment mediated by RIP1
reactomeR-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling
reactomeR-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
reactomeR-HSA-975144IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
reactomeR-HSA-975155MyD88 dependent cascade initiated on endosome
reactomeR-HSA-975871MyD88 cascade initiated on plasma membrane
reactomeR-HSA-983169Class I MHC mediated antigen processing & presentation
reactomeR-HSA-983705Signaling by the B Cell Receptor (BCR)
reactomeR-HSA-983705Signaling by the B Cell Receptor (BCR)
biocartacardiacegfpathwayrole of egf receptor transactivation by gpcrs in cardiac hypertrophy
biocartaceramidepathwayceramide signaling pathway
biocartagsk3pathwayinactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages
biocartail1rpathwaysignal transduction through il1r
biocartakeratinocytepathwaykeratinocyte differentiation
biocartamapkpathwaymapkinase signaling pathway
biocartanfkbpathwaynf-kb signaling pathway
biocartanthipathwaynfkb activation by nontypeable hemophilus influenzae
biocartaraccycdpathwayinfluence of ras and rho proteins on g1 to s transition
biocartaranklpathwaybone remodeling
biocartarnapathwaydouble stranded rna induced gene expression
biocartastresspathwaytnf/stress related signaling
biocartatffpathwaytrefoil factors initiate mucosal healing
biocartatidpathwaychaperones modulate interferon signaling pathway
biocartatollpathwaytoll-like receptor pathway
pidbcr_5pathwayBCR signaling pathway
pidcd8tcrpathwayTCR signaling in naïve CD8+ T cells
pidfaspathwayFAS (CD95) signaling pathway
pidfcer1pathwayFc-epsilon receptor I signaling in mast cells
pidfoxopathwayFoxO family signaling
pidgmcsf_pathwayGMCSF-mediated signaling events
pidil1pathwayIL1-mediated signaling events
pidmtor_4pathwaymTOR signaling pathway
pidnfkappabatypicalpathwayAtypical NF-kappaB pathway
pidnfkappabcanonicalpathwayCanonical NF-kappaB pathway
pidp75ntrpathwayp75(NTR)-mediated signaling
pidtap63pathwayValidated transcriptional targets of TAp63 isoforms
pidtcr_pathwayTCR signaling in naïve CD4+ T cells
pidtnfpathwayTNF receptor signaling pathway
pidtoll_endogenous_pathwayEndogenous TLR signaling
pidtrail_pathwayTRAIL signaling pathway
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04064NF-kappa B signaling pathway - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04620Toll-like receptor signaling pathway - Homo sapiens (human)
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
kegghsa04622RIG-I-like receptor signaling pathway - Homo sapiens (human)
kegghsa04623Cytosolic DNA-sensing pathway - Homo sapiens (human)
kegghsa04625C-type lectin receptor signaling pathway - Homo sapiens (human)
kegghsa04657IL-17 signaling pathway - Homo sapiens (human)
kegghsa04658Th1 and Th2 cell differentiation - Homo sapiens (human)
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04662B cell receptor signaling pathway - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
kegghsa04920Adipocytokine signaling pathway - Homo sapiens (human)
kegghsa04930Type II diabetes mellitus - Homo sapiens (human)
kegghsa04931Insulin resistance - Homo sapiens (human)
kegghsa04932Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
kegghsa05120Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)
kegghsa05131Shigellosis - Homo sapiens (human)
kegghsa05142Chagas disease (American trypanosomiasis) - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
kegghsa05221Acute myeloid leukemia - Homo sapiens (human)
kegghsa05222Small cell lung cancer - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
netpathPathway_BCRBCR
netpathPathway_IL1IL1
netpathPathway_IL11IL11
netpathPathway_IL4IL4
netpathPathway_LeptinLeptin
netpathPathway_RAGERAGE
netpathPathway_RANKLRANKL
netpathPathway_TCRTCR
netpathPathway_TNFalphaTNFalpha
netpathPathway_TSHTSH
netpathPathway_TWEAKTWEAK
wikipathwaysWP1433Nucleotide-binding Oligomerization Domain (NOD) pathway
wikipathwaysWP1434Osteopontin Signaling
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP1584Type II diabetes mellitus
wikipathwaysWP1772Apoptosis Modulation and Signaling
wikipathwaysWP195IL-1 signaling pathway
wikipathwaysWP2018RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway
wikipathwaysWP2034Leptin signaling pathway
wikipathwaysWP2036TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway
wikipathwaysWP2112IL17 signaling pathway
wikipathwaysWP23B Cell Receptor Signaling Pathway
wikipathwaysWP231TNF alpha Signaling Pathway
wikipathwaysWP2324AGE-RAGE pathway
wikipathwaysWP2332Interleukin-11 Signaling Pathway
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP2435Quercetin and Nf-kB- AP-1 Induced Cell Apoptosis
wikipathwaysWP254Apoptosis
wikipathwaysWP2571Polycystic Kidney Disease Pathway
wikipathwaysWP2593JAK-STAT
wikipathwaysWP262EBV LMP1 signaling
wikipathwaysWP2637Structural Pathway of Interleukin 1 (IL-1)
wikipathwaysWP2795Cardiac Hypertrophic Response
wikipathwaysWP2804Hair Follicle Development- Induction (Part 1 of 3)
wikipathwaysWP288NLR Proteins
wikipathwaysWP3303Rac1-Pak1-p38-MMP-2 pathway
wikipathwaysWP3617Photodynamic therapy-induced NF-kB survival signaling
wikipathwaysWP3639Apoptotic Signaling Pathway
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3849MAPK and NFkB Signalling Pathways Inhibited by Yersinia YopJ
wikipathwaysWP3858Toll-like Receptor Signaling
wikipathwaysWP3863T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection
wikipathwaysWP3865RIG-I-like Receptor Signaling
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP395IL-4 Signaling Pathway
wikipathwaysWP4136Fibrin Complement Receptor 3 Signaling Pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4223Ras Signaling
wikipathwaysWP481Insulin Signaling
wikipathwaysWP69T-Cell antigen Receptor (TCR) Signaling Pathway
wikipathwaysWP712Estrogen signaling pathway
wikipathwaysWP75Toll-like Receptor Signaling Pathway
smpdbSMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
smpdbSMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD60Quinoclamine2
iGMDRD64Parbendazole3
iGMDRD23Gossypol3
iGMDRD444Tivantinib3
iGMDRD286Nsc 6328393
iGMDRD871BRD63682
iGMDRD730Kahalalide F3
iGMDRD74Idarubicin3
iGMDRD506Fedratinib2
iGMDRD158NSC1415402
iGMDRD137Indisulam3
iGMDRD138PX 123
iGMDRD901ELCPK3
iGMDRD394BX-7952
iGMDRD123Isoevodiamine3
iGMDRD280CYTOCHALASIN B4
iGMDRD679Bistramide A3
iGMDRD639YK 4-2793
iGMDRD351GW843682X2
iGMDRD532Olaparib3
iGMDRD345Compound 10b [PMID: 11504634]3
iGMDRD546BMS-7548072
iGMDRD424Tamatinib1
iGMDRD494Neopeltolide3
iGMDRD781Sirolimus1
iGMDRD405PIK-751
iGMDRD387CHIR-990213
iGMDRD512nutlin 33
iGMDRD772BRD47702

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IKBKB

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