GTSE1


Summary: The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
G2 and S-phase expressed 1MIM:607477Ensembl:ENSG00000075218HGNC:HGNC:13698PA2906122q13.31

Gene Categories:

TUMOR SUPPRESSOR

GO terms in GTSE1


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005654nucleoplasm
CCTASGO:0005829cytosol
CCIDAGO:0005881cytoplasmic microtubule
CCHDAGO:0016020membrane
BPNASGO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
BPNASGO:0007017microtubule-based process
BPTASGO:0030335positive regulation of cell migration
BPTASGO:0046827positive regulation of protein export from nucleus
BPTASGO:0050821protein stabilization
BPTASGO:1900182positive regulation of protein localization to nucleus
BPTASGO:1902749regulation of cell cycle G2/M phase transition
MFNDGO:0003674molecular_function
MFIPIGO:0005515protein binding

Gene expression in normal tissue: GTSE1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GTSE1


DatabasePathway IDPathway Des.
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-453274Mitotic G2-G2/M phases
reactomeR-HSA-69275G2/M Transition
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69481G2/M Checkpoints
reactomeR-HSA-69620Cell Cycle Checkpoints
reactomeR-HSA-8852276The role of GTSE1 in G2/M progression after G2 checkpoint
kegghsa04115p53 signaling pathway - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD1008SR-II-138A6
iGMDRD148Pifithrin-mu2
iGMDRD126Tipifarnib3
iGMDRD781Sirolimus3
iGMDRD405PIK-753
iGMDRD523Cyanoquinoline, 116
iGMDRD345Compound 10b [PMID: 11504634]3
iGMDRD546BMS-7548076
iGMDRD427ABT7372
iGMDRD359OSW-13
iGMDRD375GW-4058333
iGMDRD123Isoevodiamine3
iGMDRD394BX-7951
iGMDRD280CYTOCHALASIN B6
iGMDRD77Itraconazole2
iGMDRD267Oligomycin A3
iGMDRD318PAC-13
iGMDRD885Compound 1106
iGMDRD481Dactolisib4
iGMDRD434BMS-5369242
iGMDRD780PP-302
iGMDRD506Fedratinib3
iGMDRD872BRD71376
iGMDRD887Compound 23 citrate2
iGMDRD399Selumetinib6
iGMDRD871BRD63683
iGMDRD524ISX-96

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GTSE1

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