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GTSE1

Summary: The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameG2 and S-phase expressed 1 OMIM IDMIM:607477 Ensembl IDEnsembl:ENSG00000075218 HGNC IDHGNC:HGNC:13698 PHARMGKB IDPA29061 Map Location22q13.31

Gene Categories:

TUMOR SUPPRESSOR

GO terms in GTSE1

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	TAS	GO:0005654	nucleoplasm
CC	TAS	GO:0005829	cytosol
CC	IDA	GO:0005881	cytoplasmic microtubule
CC	HDA	GO:0016020	membrane
BP	NAS	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
BP	NAS	GO:0007017	microtubule-based process

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Gene expression in normal tissue: GTSE1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GTSE1

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-1640170	Cell Cycle
reactome	R-HSA-453274	Mitotic G2-G2/M phases
reactome	R-HSA-69275	G2/M Transition
reactome	R-HSA-69278	Cell Cycle, Mitotic
reactome	R-HSA-69481	G2/M Checkpoints
reactome	R-HSA-69620	Cell Cycle Checkpoints

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD1008	SR-II-138A	6
iGMDRD148	Pifithrin-mu	2
iGMDRD126	Tipifarnib	3
iGMDRD781	Sirolimus	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GTSE1

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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