GTSE1
Summary: The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| G2 and S-phase expressed 1 | MIM:607477 | Ensembl:ENSG00000075218 | HGNC:HGNC:13698 | PA29061 | 22q13.31 |
Gene Categories:
TUMOR SUPPRESSORGO terms in GTSE1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005881 | cytoplasmic microtubule |
| CC | HDA | GO:0016020 | membrane |
| BP | NAS | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| BP | NAS | GO:0007017 | microtubule-based process |
| BP | TAS | GO:0030335 | positive regulation of cell migration |
| BP | TAS | GO:0046827 | positive regulation of protein export from nucleus |
| BP | TAS | GO:0050821 | protein stabilization |
| BP | TAS | GO:1900182 | positive regulation of protein localization to nucleus |
| BP | TAS | GO:1902749 | regulation of cell cycle G2/M phase transition |
| MF | ND | GO:0003674 | molecular_function |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: GTSE1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GTSE1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69481 | G2/M Checkpoints |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint |
| kegg | hsa04115 | p53 signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD1008 | SR-II-138A | 6 |
| iGMDRD148 | Pifithrin-mu | 2 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 6 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD546 | BMS-754807 | 6 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD359 | OSW-1 | 3 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD280 | CYTOCHALASIN B | 6 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD885 | Compound 110 | 6 |
| iGMDRD481 | Dactolisib | 4 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD872 | BRD7137 | 6 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD399 | Selumetinib | 6 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD524 | ISX-9 | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GTSE1
CLASSFICATION
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