TSSK4
Summary: This gene encodes a member of the testis-specific serine/threonine kinase family. The encoded protein is thought to be involved in spermatogenesis via stimulation of the CREB/CRE responsive pathway through phosphorylation of the cAMP responsive element binding protein transcription factor. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| testis specific serine kinase 4 | MIM:610711 | Ensembl:ENSG00000139908 | HGNC:HGNC:19825 | PA134908318 | 14q12 |
GO terms in TSSK4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000287 | magnesium ion binding |
| MF | ISS | GO:0000287 | magnesium ion binding |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | ISS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | ISS | GO:0005524 | ATP binding |
| CC | IBA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | ISS | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0007275 | multicellular organism development |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | IEA | GO:0030154 | cell differentiation |
| BP | IDA | GO:0032793 | positive regulation of CREB transcription factor activity |
| BP | IBA | GO:0035556 | intracellular signal transduction |
Gene expression in normal tissue: TSSK4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TSSK4
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD213 | SMR000068650 | 3 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TSSK4
CLASSFICATION
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