SLC14A1
Summary: The protein encoded by this gene is a membrane transporter that mediates urea transport in erythrocytes. This gene forms the basis for the Kidd blood group system. [provided by RefSeq, Mar 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| solute carrier family 14 member 1 (Kidd blood group) | MIM:613868 | Ensembl:ENSG00000141469 | HGNC:HGNC:10918 | PA35810 | 18q12.3 |
Gene Categories:
TRANSPORTERGO terms in SLC14A1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0005372 | water transmembrane transporter activity |
| MF | TAS | GO:0015204 | urea transmembrane transporter activity |
| MF | IDA | GO:0015265 | urea channel activity |
| BP | IEA | GO:0006833 | water transport |
| BP | TAS | GO:0015840 | urea transport |
| BP | TAS | GO:0055085 | transmembrane transport |
| BP | IDA | GO:0071918 | urea transmembrane transport |
| CC | IDA | GO:0005730 | nucleolus |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0016323 | basolateral plasma membrane |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
Gene expression in normal tissue: SLC14A1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLC14A1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-425366 | Transport of bile salts and organic acids, metal ions and amine compounds |
| reactome | R-HSA-425407 | SLC-mediated transmembrane transport |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD484 | Pluripotin | 3 |
| iGMDRD483 | SCH-529074 | 2 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD237 | ABT-751 | 4 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD351 | GW843682X | 5 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD883 | CIL55A | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLC14A1
CLASSFICATION
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