LZTR1
Summary: This gene encodes a member of the BTB-kelch superfamily. Initially described as a putative transcriptional regulator based on weak homology to members of the basic leucine zipper-like family, the encoded protein subsequently has been shown to localize exclusively to the Golgi network where it may help stabilize the Gogli complex. Deletion of this gene may be associated with DiGeorge syndrome. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| leucine zipper like transcription regulator 1 | MIM:600574 | Ensembl:ENSG00000099949 | HGNC:HGNC:6742 | PA30506 | 22q11.21|22q11.1-q11.2 |
GO terms in LZTR1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | TAS | GO:0009653 | anatomical structure morphogenesis |
| CC | IBA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005794 | Golgi apparatus |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
Gene expression in normal tissue: LZTR1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LZTR1
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD2 | PK-11195 | 1 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD280 | CYTOCHALASIN B | 6 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD554 | CHEMBL1434137 | 1 |
| iGMDRD330 | BRD4132 | 1 |
| iGMDRD889 | Compound 7d-cis | 1 |
| iGMDRD1008 | SR-II-138A | 1 |
| iGMDRD532 | Olaparib | 1 |
| iGMDRD150 | RITA | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 1 |
| iGMDRD286 | Nsc 632839 | 1 |
| iGMDRD367 | Ro 28-1675 | 1 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD42 | Vorinostat | 1 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD202 | Curcumin | 1 |
| iGMDRD251 | ML162 | 1 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD226 | ML006 | 5 |
| iGMDRD870 | BRD63610 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LZTR1
CLASSFICATION
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