LZTR1


Summary: This gene encodes a member of the BTB-kelch superfamily. Initially described as a putative transcriptional regulator based on weak homology to members of the basic leucine zipper-like family, the encoded protein subsequently has been shown to localize exclusively to the Golgi network where it may help stabilize the Gogli complex. Deletion of this gene may be associated with DiGeorge syndrome. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
leucine zipper like transcription regulator 1MIM:600574Ensembl:ENSG00000099949HGNC:HGNC:6742PA3050622q11.21|22q11.1-q11.2

GO terms in LZTR1


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0006355regulation of transcription, DNA-templated
BPTASGO:0009653anatomical structure morphogenesis
CCIBAGO:0005794Golgi apparatus
CCIDAGO:0005794Golgi apparatus
MFTASGO:0003700DNA-binding transcription factor activity

Gene expression in normal tissue: LZTR1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LZTR1


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD2PK-111951
iGMDRD61Kinetin riboside4
iGMDRD679Bistramide A3
iGMDRD280CYTOCHALASIN B6
iGMDRD634SCHEMBL26080413
iGMDRD126Tipifarnib3
iGMDRD554CHEMBL14341371
iGMDRD330BRD41321
iGMDRD889Compound 7d-cis1
iGMDRD1008SR-II-138A1
iGMDRD532Olaparib1
iGMDRD150RITA2
iGMDRD345Compound 10b [PMID: 11504634]1
iGMDRD286Nsc 6328391
iGMDRD367Ro 28-16751
iGMDRD871BRD63683
iGMDRD780PP-303
iGMDRD42Vorinostat1
iGMDRD322FK 8662
iGMDRD513BML-2591
iGMDRD202Curcumin1
iGMDRD251ML1621
iGMDRD441TW 371
iGMDRD226ML0065
iGMDRD870BRD636103

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LZTR1

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