TTL
Summary: TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).[supplied by OMIM, Mar 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:608291 Ensembl IDEnsembl:ENSG00000114999 HGNC IDHGNC:HGNC:21586 PHARMGKB IDPA134934330 Map Location2q14.1 | |||||
GO terms in TTL
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0000226 | microtubule cytoskeleton organization |
| BP | IMP | GO:0018166 | C-terminal protein-tyrosinylation |
| BP | IEA | GO:0030516 | regulation of axon extension |
| BP | IMP | GO:0045931 | positive regulation of mitotic cell cycle |
| BP | IMP | GO:0090235 | regulation of metaphase plate congression |
| CC | IMP | GO:0005623 | cell |
Gene expression in normal tissue: TTL
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TTL
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin |
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Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TTL
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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