TTL
Summary: TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| tubulin tyrosine ligase | MIM:608291 | Ensembl:ENSG00000114999 | HGNC:HGNC:21586 | PA134934330 | 2q14.1 |
GO terms in TTL
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0000226 | microtubule cytoskeleton organization |
| BP | IMP | GO:0018166 | C-terminal protein-tyrosinylation |
| BP | IEA | GO:0030516 | regulation of axon extension |
| BP | IMP | GO:0045931 | positive regulation of mitotic cell cycle |
| BP | IMP | GO:0090235 | regulation of metaphase plate congression |
| CC | IMP | GO:0005623 | cell |
| MF | IMP | GO:0004835 | tubulin-tyrosine ligase activity |
| MF | IEA | GO:0005524 | ATP binding |
Gene expression in normal tissue: TTL
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TTL
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD137 | Indisulam | 6 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD314 | Tanespimycin | 4 |
| iGMDRD177 | Teniposide | 6 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD512 | nutlin 3 | 4 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 6 |
| iGMDRD150 | RITA | 6 |
| iGMDRD405 | PIK-75 | 6 |
| iGMDRD74 | Idarubicin | 6 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD524 | ISX-9 | 6 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD171 | Pemetrexed | 1 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD634 | SCHEMBL2608041 | 6 |
| iGMDRD554 | CHEMBL1434137 | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD494 | Neopeltolide | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TTL
CLASSFICATION
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